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European Journal of Nutrition

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01-02-2014 | Original Contribution

Increased vitamin D-binding protein and decreased free 25(OH)D in obese women of reproductive age

Authors: Therese Karlsson, Amra Osmancevic, Nina Jansson, Lena Hulthén, Agneta Holmäng, Ingrid Larsson

Published in: European Journal of Nutrition | Issue 1/2014

Abstract

Purpose

Obese subjects have lower circulating 25-hydroxyvitamin D (25(OH)D) than normal-weight subjects. Knowledge is scarce regarding differences in vitamin D-binding protein (DBP), free 25(OH)D, and intake of vitamin D between normal-weight and obese subjects. The purpose of this study was to examine intake and vitamin D status in obese compared with normal-weight women.

Methods

Between September 2009 and October 2011, 43 obese and 43 normal-weight women, 22–45 years of age, mean BMI of 39.1 ± 4.6 and 21.6 ± 1.8 kg/m², respectively, were recruited in the western Sweden region (latitude 57°N). Blood samples, data regarding diet, and sun exposure were collected.

Results

DBP concentrations were 320 ± 121 and 266 ± 104 μg/mL (P = 0.02) in obese and normal-weight women, respectively. Calculated free 25(OH)D was 13.3 ± 5.5 (obese) and 23.7 ± 10.7 (normal-weight) (P < 0.001). The obese women had a 20.1 nmol/L lower mean 25(HO)D concentration compared to normal-weight women (P < 0.001). 56 % of obese women and 12 % of normal-weight women had 25(OH)D concentrations ≤50 nmol/L. There was no statistically significant difference in total vitamin D intake between the groups. 39 % of the women had a total vitamin D intake <7.5 μg/day, the current national recommendation for vitamin D in Sweden.

Conclusions

Obese women had higher DBP concentrations compared with normal-weight women and lower free 25(OH)D. The obese women were more likely to have 25(OH)D concentrations that could be considered suboptimal. Vitamin D intake was generally low in normal-weight and obese women of childbearing age.

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Title: Increased vitamin D-binding protein and decreased free 25(OH)D in obese women of reproductive age
Authors: Therese Karlsson
Amra Osmancevic
Nina Jansson
Lena Hulthén
Agneta Holmäng
Ingrid Larsson
Publication date: 01-02-2014
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nutrition / Issue 1/2014
Print ISSN: 1436-6207
Electronic ISSN: 1436-6215
DOI: https://doi.org/10.1007/s00394-013-0524-8

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