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01-09-2012 | Translational Research and Biomarkers

Increased Risk for CRC in Diabetic Patients with the Nonrisk Allele of SNPs at 8q24

Authors: Shinya Ishimaru, MD, PhD, Koshi Mimori, MD, PhD, Ken Yamamoto, MD, PhD, Hiroshi Inoue, MD, PhD, Seiya Imoto, PhD, Shuichi Kawano, PhD, Rui Yamaguchi, PhD, Tetsuya Sato, PhD, Hiroyuki Toh, MD, PhD, Hisae Iinuma, PhD, Toyoki Maeda, MD, PhD, Hideshi Ishii, MD, PhD, Sadao Suzuki, PhD, Shinkan Tokudome, PhD, Masahiko Watanabe, MD, PhD, Jun-ichi Tanaka, MD, PhD, Shin-ei Kudo, MD, PhD, Ken-ichi Sugihara, MD, PhD, Kazuo Hase, MD, PhD, Hidetaka Mochizuki, MD, PhD, Masato Kusunoki, MD, PhD, Kazutaka Yamada, MD, PhD, Yasuhiro Shimada, MD, PhD, Yoshihiro Moriya, MD, PhD, Graham F. Barnard, MD, PhD, Satoru Miyano, PhD, Masaki Mori, MD, PhD

Published in: Annals of Surgical Oncology | Issue 9/2012

Abstract

Background

Colorectal cancer (CRC) oncogenesis was considered to be determined by interactions between genetic and environmental factors. Specific interacting factors that influence CRC morbidity have yet to be fully investigated.

Methods

A multi-institutional collaborative study with 1511 CRC patients and 2098 control subjects was used to compare the odds ratios for the occurrence of polymorphisms at 11 known single nucleotide polymorphisms (SNPs). TaqMan PCR and questionnaires were used to evaluate the effects of environmental exposures.

Results

Variants of rs6983267 on 8q24 were the most significant markers of risk for CRC (odds ratio 1.16, 95% confidence interval 1.06–1.27, P = 0.0015). Non-insulin-dependent diabetes mellitus (DM), a higher body mass index at age 20, and meat consumption were environmental risk factors, whereas a tuna-rich diet and vitamin intake were protective factors. The cohort of rs6983267 SNP major (T) allele at 8q24 and DM had a 1.66-fold higher risk ratio than the cohort of major allele patients without DM.

Conclusions

We confirmed that interactions between the genetic background and environmental factors are associated with increased risk for CRC. There is a robust risk of the minor G allele at the 8q24 rs6983267 SNP; however, a major T allele SNP could more clearly reveal a correlation with CRC specifically when DM is present.

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Title: Increased Risk for CRC in Diabetic Patients with the Nonrisk Allele of SNPs at 8q24
Authors: Shinya Ishimaru, MD, PhD
Koshi Mimori, MD, PhD
Ken Yamamoto, MD, PhD
Hiroshi Inoue, MD, PhD
Seiya Imoto, PhD
Shuichi Kawano, PhD
Rui Yamaguchi, PhD
Tetsuya Sato, PhD
Hiroyuki Toh, MD, PhD
Hisae Iinuma, PhD
Toyoki Maeda, MD, PhD
Hideshi Ishii, MD, PhD
Sadao Suzuki, PhD
Shinkan Tokudome, PhD
Masahiko Watanabe, MD, PhD
Jun-ichi Tanaka, MD, PhD
Shin-ei Kudo, MD, PhD
Ken-ichi Sugihara, MD, PhD
Kazuo Hase, MD, PhD
Hidetaka Mochizuki, MD, PhD
Masato Kusunoki, MD, PhD
Kazutaka Yamada, MD, PhD
Yasuhiro Shimada, MD, PhD
Yoshihiro Moriya, MD, PhD
Graham F. Barnard, MD, PhD
Satoru Miyano, PhD
Masaki Mori, MD, PhD
Publication date: 01-09-2012
Publisher: Springer-Verlag
Published in: Annals of Surgical Oncology / Issue 9/2012
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-012-2278-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Increased Risk for CRC in Diabetic Patients with the Nonrisk Allele of SNPs at 8q24

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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