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European Archives of Psychiatry and Clinical Neuroscience

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01-10-2008 | SHORT COMMUNICATION

Increased NAA and reduced choline levels in the anterior cingulum following chronic methylphenidate

A spectroscopic test–retest study in adult ADHD

Authors: Golo Kronenberg, Gabriele Ende, Barbara Alm, Michael Deuschle, Isabella Heuser, Michael Colla

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 7/2008

Abstract

The anterior cingulate cortex (ACC) is crucially involved in executive control of attention. Here, seven medication-naïve adult patients suffering from attention deficit/hyperactivity disorder (ADHD) were studied with 2D ¹H-magnetic resonance spectroscopic imaging (MRSI) of the ACC [Brodmann areas 24b′–c′ and 32′] twice, once before initiation of stimulant treatment and once after 5–6 weeks of methylphenidate. Upon retest, all patients demonstrated marked clinical improvement. Analysis of regional brain spectra revealed a significantly decreased signal of choline containing compounds as well as increased N-acetyl-aspartate (NAA) levels following treatment with methylphenidate whereas total creatine remained unchanged. Our results add to a growing body of evidence implicating the ACC in the pathophysiology of ADHD and suggest that subtle structural changes might be associated with aspects of clinical improvement under stimulant treatment.

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Title: Increased NAA and reduced choline levels in the anterior cingulum following chronic methylphenidate
A spectroscopic test–retest study in adult ADHD
Authors: Golo Kronenberg
Gabriele Ende
Barbara Alm
Michael Deuschle
Isabella Heuser
Michael Colla
Publication date: 01-10-2008
Publisher: D. Steinkopff-Verlag
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 7/2008
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-008-0810-2

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Increased NAA and reduced choline levels in the anterior cingulum following chronic methylphenidate

A spectroscopic test–retest study in adult ADHD

Abstract

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

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