Skip to main content
Top
Published in: European Spine Journal 1/2017

01-01-2017 | Grand Rounds

Increased intrathecal pressure after traumatic spinal cord injury: an illustrative case presentation and a review of the literature

Authors: Lukas Grassner, Peter A. Winkler, Martin Strowitzki, Volker Bühren, Doris Maier, Michael Bierschneider

Published in: European Spine Journal | Issue 1/2017

Login to get access

Abstract https://static-content.springer.com/image/art%3A10.1007%2Fs00586-016-4769-9/MediaObjects/586_2016_4769_Figa_HTML.jpg

Purpose

Early surgical management after traumatic spinal cord injury (SCI) is nowadays recommended. Since posttraumatic ischemia is an important sequel after SCI, maintenance of an adequate mean arterial pressure (MAP) within the first week remains crucial in order to warrant sufficient spinal cord perfusion. However, the contribution of raised intraparenchymal and consecutively increased intrathecal pressure has not been implemented in treatment strategies.

Methods

Case report and review of the literature.

Results

Here we report a case of a 54-year old man who experienced a thoracic spinal cord injury after a fall. CT-examination revealed complex fractures of the thoracic spine. The patient underwent prompt surgical intervention. Intraoperatively, fractured parts of the ascending Th5 facet joint were displaced into the spinal cord itself. Upon removal, excessive protruding of medullary tissue was observed over several minutes. This demonstrates the clinical relevance of increased intrathecal pressure in some patients.

Conclusion

Monitoring and counteracting raised intrathecal pressure should guide clinical decision-making in the future in order to ensure optimal spinal cord perfusion pressure for every affected individual.
Literature
2.
go back to reference Perkins PG, Deane RH (1988) Long-term follow-up of six patients with acute spinal injury following dural decompression. Injury 19:397–401CrossRefPubMed Perkins PG, Deane RH (1988) Long-term follow-up of six patients with acute spinal injury following dural decompression. Injury 19:397–401CrossRefPubMed
3.
go back to reference Zhu H, Feng YP, Young W, You SW, Shen XF, Liu YS, Ju G (2008) Early neurosurgical intervention of spinal cord contusion: an analysis of 30 cases. Chin Med J 121:2473–2478PubMed Zhu H, Feng YP, Young W, You SW, Shen XF, Liu YS, Ju G (2008) Early neurosurgical intervention of spinal cord contusion: an analysis of 30 cases. Chin Med J 121:2473–2478PubMed
4.
go back to reference Walters BC, Hadley MN, Hurlbert RJ, Aarabi B, Dhall SS, Gelb DE, Harrigan MR, Rozelle CJ, Ryken TC, Theodore N, American Association of Neurological S, Congress of Neurological S (2013) Guidelines for the management of acute cervical spine and spinal cord injuries: 2013 update. Neurosurgery 60(Suppl 1):82–91. doi:10.1227/01.neu.0000430319.32247.7f CrossRefPubMed Walters BC, Hadley MN, Hurlbert RJ, Aarabi B, Dhall SS, Gelb DE, Harrigan MR, Rozelle CJ, Ryken TC, Theodore N, American Association of Neurological S, Congress of Neurological S (2013) Guidelines for the management of acute cervical spine and spinal cord injuries: 2013 update. Neurosurgery 60(Suppl 1):82–91. doi:10.​1227/​01.​neu.​0000430319.​32247.​7f CrossRefPubMed
5.
8.
go back to reference Kwon BK, Curt A, Belanger LM, Bernardo A, Chan D, Markez JA, Gorelik S, Slobogean GP, Umedaly H, Giffin M, Nikolakis MA, Street J, Boyd MC, Paquette S, Fisher CG, Dvorak MF (2009) Intrathecal pressure monitoring and cerebrospinal fluid drainage in acute spinal cord injury: a prospective randomized trial. J Neurosurg Spine 10:181–193. doi:10.3171/2008.10.SPINE08217 CrossRefPubMed Kwon BK, Curt A, Belanger LM, Bernardo A, Chan D, Markez JA, Gorelik S, Slobogean GP, Umedaly H, Giffin M, Nikolakis MA, Street J, Boyd MC, Paquette S, Fisher CG, Dvorak MF (2009) Intrathecal pressure monitoring and cerebrospinal fluid drainage in acute spinal cord injury: a prospective randomized trial. J Neurosurg Spine 10:181–193. doi:10.​3171/​2008.​10.​SPINE08217 CrossRefPubMed
9.
go back to reference Marmarou A (2007) A review of progress in understanding the pathophysiology and treatment of brain edema. Neurosurg Focus 22:E1 Marmarou A (2007) A review of progress in understanding the pathophysiology and treatment of brain edema. Neurosurg Focus 22:E1
12.
go back to reference Fehlings MG, Vaccaro A, Wilson JR, Singh A, Cadotte DW, Harrop JS, Aarabi B, Shaffrey C, Dvorak M, Fisher C, Arnold P, Massicotte EM, Lewis S, Rampersaud R (2012) Early versus delayed decompression for traumatic cervical spinal cord injury: results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS). PLoS One 7:e32037. doi:10.1371/journal.pone.0032037 CrossRefPubMedPubMedCentral Fehlings MG, Vaccaro A, Wilson JR, Singh A, Cadotte DW, Harrop JS, Aarabi B, Shaffrey C, Dvorak M, Fisher C, Arnold P, Massicotte EM, Lewis S, Rampersaud R (2012) Early versus delayed decompression for traumatic cervical spinal cord injury: results of the Surgical Timing in Acute Spinal Cord Injury Study (STASCIS). PLoS One 7:e32037. doi:10.​1371/​journal.​pone.​0032037 CrossRefPubMedPubMedCentral
13.
go back to reference Grassner L, Wutte C, Klein B, Mach O, Riesner S, Panzer S, Vogel M, Buhren V, Strowitzki M, Vastmans J, Maier D (2016) Early decompression (<8 h) after traumatic cervical spinal cord injury improves functional outcome as assessed by Spinal Cord Independence Measure (SCIM) after 1 year. J Neurotrauma. doi:10.1089/neu.2015.4325 PubMed Grassner L, Wutte C, Klein B, Mach O, Riesner S, Panzer S, Vogel M, Buhren V, Strowitzki M, Vastmans J, Maier D (2016) Early decompression (<8 h) after traumatic cervical spinal cord injury improves functional outcome as assessed by Spinal Cord Independence Measure (SCIM) after 1 year. J Neurotrauma. doi:10.​1089/​neu.​2015.​4325 PubMed
14.
go back to reference Jug M, Kejzar N, Vesel M, Al Mawed S, Dobravec M, Herman S, Bajrovic FF (2015) Neurological recovery after traumatic cervical spinal cord injury is superior if surgical decompression and instrumented fusion are performed within 8 h versus 8–24 h after injury: a single center experience. J Neurotrauma. doi:10.1089/neu.2014.3767 PubMed Jug M, Kejzar N, Vesel M, Al Mawed S, Dobravec M, Herman S, Bajrovic FF (2015) Neurological recovery after traumatic cervical spinal cord injury is superior if surgical decompression and instrumented fusion are performed within 8 h versus 8–24 h after injury: a single center experience. J Neurotrauma. doi:10.​1089/​neu.​2014.​3767 PubMed
15.
go back to reference Carlson GD, Gorden CD, Nakazowa S, Wada E, Warden K, LaManna JC (2000) Perfusion-limited recovery of evoked potential function after spinal cord injury. Spine 25:1218–1226CrossRefPubMed Carlson GD, Gorden CD, Nakazowa S, Wada E, Warden K, LaManna JC (2000) Perfusion-limited recovery of evoked potential function after spinal cord injury. Spine 25:1218–1226CrossRefPubMed
17.
go back to reference Werndle MC, Saadoun S, Phang I, Czosnyka M, Varsos GV, Czosnyka ZH, Smielewski P, Jamous A, Bell BA, Zoumprouli A, Papadopoulos MC (2014) Monitoring of spinal cord perfusion pressure in acute spinal cord injury: initial findings of the injured spinal cord pressure evaluation study*. Crit Care Med 42:646–655. doi:10.1097/CCM.0000000000000028 CrossRefPubMed Werndle MC, Saadoun S, Phang I, Czosnyka M, Varsos GV, Czosnyka ZH, Smielewski P, Jamous A, Bell BA, Zoumprouli A, Papadopoulos MC (2014) Monitoring of spinal cord perfusion pressure in acute spinal cord injury: initial findings of the injured spinal cord pressure evaluation study*. Crit Care Med 42:646–655. doi:10.​1097/​CCM.​0000000000000028​ CrossRefPubMed
18.
go back to reference Phang I, Werndle MC, Saadoun S, Varsos G, Czosnyka M, Zoumprouli A, Papadopoulos MC (2015) Expansion duroplasty improves intraspinal pressure, spinal cord perfusion pressure, and vascular pressure reactivity index in patients with traumatic spinal cord injury: injured spinal cord pressure evaluation study. J Neurotrauma 32:865–874. doi:10.1089/neu.2014.3668 CrossRefPubMedPubMedCentral Phang I, Werndle MC, Saadoun S, Varsos G, Czosnyka M, Zoumprouli A, Papadopoulos MC (2015) Expansion duroplasty improves intraspinal pressure, spinal cord perfusion pressure, and vascular pressure reactivity index in patients with traumatic spinal cord injury: injured spinal cord pressure evaluation study. J Neurotrauma 32:865–874. doi:10.​1089/​neu.​2014.​3668 CrossRefPubMedPubMedCentral
19.
go back to reference Phang I, Papadopoulos MC (2015) Intraspinal pressure monitoring in a patient with spinal cord injury reveals different intradural compartments: injured spinal cord pressure evaluation (ISCoPE) study. Neurocrit Care 23:414–418. doi:10.1007/s12028-015-0153-6 CrossRefPubMed Phang I, Papadopoulos MC (2015) Intraspinal pressure monitoring in a patient with spinal cord injury reveals different intradural compartments: injured spinal cord pressure evaluation (ISCoPE) study. Neurocrit Care 23:414–418. doi:10.​1007/​s12028-015-0153-6 CrossRefPubMed
20.
22.
go back to reference Sharma HS, Winkler T, Stalberg E, Olsson Y, Dey PK (1991) Evaluation of traumatic spinal cord edema using evoked potentials recorded from the spinal epidural space. An experimental study in the rat. J Neurol Sci 102:150–162CrossRefPubMed Sharma HS, Winkler T, Stalberg E, Olsson Y, Dey PK (1991) Evaluation of traumatic spinal cord edema using evoked potentials recorded from the spinal epidural space. An experimental study in the rat. J Neurol Sci 102:150–162CrossRefPubMed
24.
go back to reference Phang I, Zoumprouli A, Saadoun S, Papadopoulos MC (2016) Safety profile and probe placement accuracy of intraspinal pressure monitoring for traumatic spinal cord injury: injured spinal cord pressure evaluation study. J Neurosurg Spine. doi:10.3171/2016.1.SPINE151317 PubMed Phang I, Zoumprouli A, Saadoun S, Papadopoulos MC (2016) Safety profile and probe placement accuracy of intraspinal pressure monitoring for traumatic spinal cord injury: injured spinal cord pressure evaluation study. J Neurosurg Spine. doi:10.​3171/​2016.​1.​SPINE151317 PubMed
26.
go back to reference LoPachin RM, Gaughan CL, Lehning EJ, Kaneko Y, Kelly TM, Blight A (1999) Experimental spinal cord injury: spatiotemporal characterization of elemental concentrations and water contents in axons and neuroglia. J Neurophysiol 82:2143–2153PubMed LoPachin RM, Gaughan CL, Lehning EJ, Kaneko Y, Kelly TM, Blight A (1999) Experimental spinal cord injury: spatiotemporal characterization of elemental concentrations and water contents in axons and neuroglia. J Neurophysiol 82:2143–2153PubMed
31.
go back to reference Carlson GD, Warden KE, Barbeau JM, Bahniuk E, Kutina-Nelson KL, Biro CL, Bohlman HH, LaManna JC (1997) Viscoelastic relaxation and regional blood flow response to spinal cord compression and decompression. Spine 22:1285–1291CrossRefPubMed Carlson GD, Warden KE, Barbeau JM, Bahniuk E, Kutina-Nelson KL, Biro CL, Bohlman HH, LaManna JC (1997) Viscoelastic relaxation and regional blood flow response to spinal cord compression and decompression. Spine 22:1285–1291CrossRefPubMed
33.
go back to reference Guha A, Tator CH, Rochon J (1989) Spinal cord blood flow and systemic blood pressure after experimental spinal cord injury in rats. Stroke 20:372–377CrossRefPubMed Guha A, Tator CH, Rochon J (1989) Spinal cord blood flow and systemic blood pressure after experimental spinal cord injury in rats. Stroke 20:372–377CrossRefPubMed
Metadata
Title
Increased intrathecal pressure after traumatic spinal cord injury: an illustrative case presentation and a review of the literature
Authors
Lukas Grassner
Peter A. Winkler
Martin Strowitzki
Volker Bühren
Doris Maier
Michael Bierschneider
Publication date
01-01-2017
Publisher
Springer Berlin Heidelberg
Published in
European Spine Journal / Issue 1/2017
Print ISSN: 0940-6719
Electronic ISSN: 1432-0932
DOI
https://doi.org/10.1007/s00586-016-4769-9

Other articles of this Issue 1/2017

European Spine Journal 1/2017 Go to the issue