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Open Access 01-03-2012 | Original Communication

Increased expression of endothelial lipase in symptomatic and unstable carotid plaques

Authors: Matias Trbušić, Monika Riederer, Majda Vučić, Ivo Lovričević, Božo Krušlin, Martin Gauster, Sonja Mohrenz, Andrea Berghold, Beate Tiran, Vesna Degoricija, Saša Frank

Published in: Journal of Neurology | Issue 3/2012

Abstract

The aim of this study was to evaluate endothelial lipase (EL) protein expression in advanced human carotid artery plaques (HCAP) with regard to plaque (in)stability and the incidence of symptoms. HCAP were collected from 66 patients undergoing carotid endarterectomy (CEA). The degree of plaque (in)stability was estimated by ultrasound and histology. In HCAP sections, EL expression was determined by immunostaining and the intensity was assessed on a semi-quantitative scale (low: <25%, high: >25% positive cells). Monocytes and macrophages in adjacent HCAP sections were stained with a CD163 specific antibody. High EL staining was more prevalent in histologically unstable plaques (in 33.3% of fibrous plaques, 50% of ulcerated non-complicated plaques and 79.2% of ulcerated complicated plaques; χ² test, p = 0.004) and in the symptomatic group (70.8 vs. 42.9% in the asymptomatic group; χ² test, p = 0.028). The majority of EL immunostaining was found in those HCAP regions exhibiting a strong CD163 immunostaining. EL in HCAP might be a marker and/or promoter of plaque instability and HCAP-related symptomatology.

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Title: Increased expression of endothelial lipase in symptomatic and unstable carotid plaques
Authors: Matias Trbušić
Monika Riederer
Majda Vučić
Ivo Lovričević
Božo Krušlin
Martin Gauster
Sonja Mohrenz
Andrea Berghold
Beate Tiran
Vesna Degoricija
Saša Frank
Publication date: 01-03-2012
Publisher: Springer-Verlag
Published in: Journal of Neurology / Issue 3/2012
Print ISSN: 0340-5354
Electronic ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-011-6198-3

At a glance: The STEP trials

Springer Medicine

Increased expression of endothelial lipase in symptomatic and unstable carotid plaques

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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