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Published in: Japanese Journal of Ophthalmology 4/2015

01-07-2015 | Clinical Investigation

Increased choroidal blood flow velocity with regression of unilateral acute idiopathic maculopathy

Authors: Yuki Hashimoto, Wataru Saito, Michiyuki Saito, Kiriko Hirooka, Shohei Mori, Kousuke Noda, Susumu Ishida

Published in: Japanese Journal of Ophthalmology | Issue 4/2015

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Abstract

Purpose

The pathogenesis of unilateral acute idiopathic maculopathy (UAIM) is unknown. The aim of this study was to quantitatively examine changes in choroidal circulation hemodynamics in patients with UAIM.

Methods

This was a retrospective observational case-series which included five eyes of four patients with UAIM. All UAIM eyes and the fellow eyes in remaining three patients were studied using laser speckle flowgraphy (LSFG) to evaluate the mean blur rate (MBR), a quantitative index of relative blood flow velocity. The changes in MBR between the initial visit and after 1 and 3 months were statistically analyzed. Subfoveal choroidal thickness was measured in three UAIM eyes by enhanced depth imaging optical coherence tomography.

Results

The mean logMAR value of best-corrected visual acuity in the UAIM eyes significantly improved (P = 0.04) with recovery of outer retinal morphology. The average MBR of the UAIM eyes significantly increased at 1 (+21.7 % baseline value; P = 0.003) and 3 months (+32.5 % baseline value; P = 0.001), whereas the fellow eyes did not show this tendency. The mean values of subfoveal choroidal thickness decreased with time (316.0 µm at baseline, 186.6 µm at 1 month, and 167.3 µm at 3 months).

Conclusions

These results reveal that there is a significant elevation of choroidal blood flow velocity and substantial reduction of choroidal thickness with regression of UAIM, suggesting that impaired choroidal circulation may be involved in the pathogenesis of UAIM.
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Metadata
Title
Increased choroidal blood flow velocity with regression of unilateral acute idiopathic maculopathy
Authors
Yuki Hashimoto
Wataru Saito
Michiyuki Saito
Kiriko Hirooka
Shohei Mori
Kousuke Noda
Susumu Ishida
Publication date
01-07-2015
Publisher
Springer Japan
Published in
Japanese Journal of Ophthalmology / Issue 4/2015
Print ISSN: 0021-5155
Electronic ISSN: 1613-2246
DOI
https://doi.org/10.1007/s10384-015-0380-6

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