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European Journal of Nuclear Medicine and Molecular Imaging

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01-04-2014 | Original Article

Increased brain amyloid deposition in patients with a lifetime history of major depression: evidenced on ¹⁸F-florbetapir (AV-45/Amyvid) positron emission tomography

Authors: Kuan-Yi Wu, Ing-Tsung Hsiao, Cheng-Sheng Chen, Chia-Hsiang Chen, Chia-Ju Hsieh, Yau-Yau Wai, Chee-Jen Chang, Hsiao-Jung Tseng, Tzue-Chen Yen, Chia-Yih Liu, Kun-Ju Lin

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 4/2014

Abstract

Purpose

The literature suggests that a history of depression is associated with an increased risk of developing Alzheimer’s disease (AD). The aim of this study was to examine brain amyloid accumulation in patients with lifetime major depression using ¹⁸F-florbetapir (AV-45/Amyvid) PET imaging in comparison with that in nondepressed subjects.

Methods

The study groups comprised 25 depressed patients and 11 comparison subjects who did not meet the diagnostic criteria for AD or amnestic mild cognitive impairment. Vascular risk factors, homocysteine and apolipoprotein E (ApoE) genotype were also examined. The standard uptake value ratio (SUVR) of each volume of interest was analysed using whole the cerebellum as the reference region.

Results

Patients with a lifetime history of major depression had higher ¹⁸F-florbetapir SUVRs in the precuneus (1.06 ± 0.08 vs. 1.00 ± 0.06, p = 0.045) and parietal region (1.05 ± 0.08 vs. 0.98 ± 0.07, p = 0.038) than the comparison subjects. Voxel-wise analysis revealed a significantly increased SUVR in depressed patients in the frontal, parietal, temporal and occipital areas (p < 0.01). There were no significant associations between global ¹⁸F-florbetapir SUVRs and prior depression episodes, age at onset of depression, or time since onset of first depression.

Conclusion

Increased ¹⁸F-florbetapir binding values were found in patients with late-life major depression relative to comparison subjects in specific brain regions, despite no differences in age, sex, education, Mini Mental Status Examination score, vascular risk factor score, homocysteine and ApoE ε4 genotype between the two groups. A longitudinal follow-up study with a large sample size would be worthwhile.

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Title: Increased brain amyloid deposition in patients with a lifetime history of major depression: evidenced on 18F-florbetapir (AV-45/Amyvid) positron emission tomography
Authors: Kuan-Yi Wu
Ing-Tsung Hsiao
Cheng-Sheng Chen
Chia-Hsiang Chen
Chia-Ju Hsieh
Yau-Yau Wai
Chee-Jen Chang
Hsiao-Jung Tseng
Tzue-Chen Yen
Chia-Yih Liu
Kun-Ju Lin
Publication date: 01-04-2014
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 4/2014
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-013-2627-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Increased brain amyloid deposition in patients with a lifetime history of major depression: evidenced on ¹⁸F-florbetapir (AV-45/Amyvid) positron emission tomography

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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