Published in:
01-02-2013 | Technical Note
Incompatibility of Contrast Medium and Trisodium Citrate
Published in: CardioVascular and Interventional Radiology | Issue 1/2013
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Purpose
To test the compatibility of trisodium citrate, a catheter lock solution, with iodinated contrast medium.
Methods
Iohexol, iobitridol, iodixanol, ioxaglate, ioxithalamate, iomeprol, and iopromide were tested. In all tests, 2 ml of contrast medium were mixed with 2 ml of trisodium citrate solution.
Results
Iodixanol and ioxaglate provoked a highly viscous gluelike precipitation when mixed with trisodium citrate. A brief transient precipitate was observed with iohexol, iomeprol, and ioxithalamate. Permanent precipitation occurred with iobitridol and iopromide.
Conclusion
One must be aware of the potential for precipitation when contrast medium is mixed with trisodium citrate solution. Before trisodium citrate solution is injected, the catheter should be thoroughly flushed with saline if a contrast medium has previously been injected through it.