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Strahlentherapie und Onkologie
Published in: Strahlentherapie und Onkologie 7/2016

01-07-2016 | Original Article

Inclined head position improves dose distribution during hippocampal-sparing whole brain radiotherapy using VMAT

Authors: Kyung Su Kim, MD, Suk-Jin Seo, BS, Jaegi Lee, BS, Jin-Yong Seok, CMD, Joo Wan Hong, BS, Jin-Beom Chung, PhD, Eunji Kim, MD, Noorie Choi, MD, Keun-Yong Eom, MD, PhD, Jae-Sung Kim, MD, PhD, In Ah Kim, MD, PhD

Published in: Strahlentherapie und Onkologie | Issue 7/2016

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Abstract

Purpose

Hippocampal-sparing whole brain radiotherapy (HS-WBRT) aims to preserve neurocognitive functions in patients undergoing brain radiotherapy (RT). Volumetric modulated arc therapy (VMAT) involves intensity-modulated RT using a coplanar arc. An inclined head position might improve dose distribution during HS-WBRT using VMAT.

Materials and methods

This study analyzed 8 patients receiving brain RT with inclined head positioning. A comparable set of CT images simulating a non-inclined head position was obtained by rotating the original CT set. HS-WBRT plans of coplanar VMAT for each CT set were generated with a prescribed dose of 30 Gy in 10 fractions. Maximum dose to the hippocampi was limited to 16 Gy; to the optic nerve, optic chiasm, and eyeballs this was confined to less than 37.5 Gy; for the lenses to 8 Gy. Dosimetric parameters of the two different plans of 8 patients were compared with paired t-test.

Results

Mean inclined head angle was 11.09 ± 0.73°. The homogeneity (HI) and conformity (CI) indexes demonstrated improved results, with an average 8.4 ± 10.0 % (p = 0.041) and 5.3 ± 3.9 % (p = 0.005) reduction, respectively, in the inclined vs. non-inclined position. The inclined head position had lower hippocampi Dmin (10.45 ± 0.36 Gy), Dmax (13.70 ± 0.25 Gy), and Dmean (12.01 ± 0.38 Gy) values vs. the non-inclined head position (Dmin = 12.07 ± 1.07 Gy; Dmax = 15.70 ± 1.25 Gy; Dmean = 13.91 ± 1.01 Gy), with 12.8 ± 8.9 % (p = 0.007), 12.2 ± 6.8 % (p = 0.003), and 13.2 ± 7.2 % (p = 0.002) reductions, respectively. Mean Dmax for the lenses was 6.34 ± 0.72 Gy and 7.60 ± 0.46 Gy, respectively, with a 16.3 ± 10.8 % reduction in the inclined position (p = 0.004). Dmax for the optic nerve and Dmean for the eyeballs also decreased by 7.0 ± 5.9 % (p = 0.015) and 8.4 ± 7.2 % (p = 0.015), respectively.

Conclusion

Inclining the head position to approximately 11° during HS-WBRT using VMAT improved dose distribution in the planning target volume and allowed lower doses to the hippocampi and optic apparatus.
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Metadata
Title
Inclined head position improves dose distribution during hippocampal-sparing whole brain radiotherapy using VMAT
Authors
Kyung Su Kim, MD
Suk-Jin Seo, BS
Jaegi Lee, BS
Jin-Yong Seok, CMD
Joo Wan Hong, BS
Jin-Beom Chung, PhD
Eunji Kim, MD
Noorie Choi, MD
Keun-Yong Eom, MD, PhD
Jae-Sung Kim, MD, PhD
In Ah Kim, MD, PhD
Publication date
01-07-2016
Publisher
Springer Berlin Heidelberg
Published in
Strahlentherapie und Onkologie / Issue 7/2016
Print ISSN: 0179-7158
Electronic ISSN: 1439-099X
DOI
https://doi.org/10.1007/s00066-016-0973-0

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