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Open Access 01-12-2022 | Incision | Research article

Tranexamic acid combined with compression dressing reduces blood loss in gluteal muscle contracture surgery

Authors: Jun Ma, ZeYu Huang, Qiang Huang, ZongKe Zhou, FuXing Pei, Bin Shen

Published in: BMC Surgery | Issue 1/2022

Abstract

Background

Blood loss and incision-related complications caused by the surgical procedure to release gluteal muscle contracture (GMC) put negative effects on the surgical outcomes. Current procedures to prevent blood loss and complications are not satisfactory. The current study aimed to determine whether tranexamic acid (TXA) in combination with pressure dressing reduce the amount of blood loss, the rate of incision-related complications, and the rate of readmission for patients undergoing surgeries to release GMC.

Methods

49 GMC patients were finally included in the study and were randomly divided into two groups: study group and control group. Patients in both groups received minimally invasive surgery to release GMC except that in the study group, patients were administered a dosage of 20 mg/kg of intravenous TXA preoperatively, and 2 subsequent dosages of TXA at 10 mg/kg at two time points: 3 and 6 h after the first dose. Gauze soaked with TXA was used to pack the wound for 10 min before the incision closure. Then the wound was pressure-wrapped with a hip-spica bandage for 24 h after the surgery in the study group.

Results

The level of UBL in the study group was significantly lower compared to that in the control group. Similar results were also found for UMHD and UMAD. The incision-related postoperative complications were greatly decreased in the study group compared to those of the control group as well. So was the 30-day readmission rate. All patients in both groups reached “excellent” or “good” level with respect to the postoperative function evaluation.

Conclusions

Intravenous and topical application of TXA combined with 24 h pressure hip-spica bandage reduces perioperative blood loss, rate of incision-related complications, and the rate of readmission for GMC patients undergoing minimally invasive surgical releasing procedure.

Trial Registration Chinese Clinical and Trial Registry ChiCTR2000039216, registration date 2020/10/22, retrospectively registered

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Title: Tranexamic acid combined with compression dressing reduces blood loss in gluteal muscle contracture surgery
Authors: Jun Ma
ZeYu Huang
Qiang Huang
ZongKe Zhou
FuXing Pei
Bin Shen
Publication date: 01-12-2022
Publisher: BioMed Central
Keywords: Incision
Tranexamic Acid
Published in: BMC Surgery / Issue 1/2022
Electronic ISSN: 1471-2482
DOI: https://doi.org/10.1186/s12893-022-01497-z

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Tranexamic acid combined with compression dressing reduces blood loss in gluteal muscle contracture surgery

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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