Top

Published in:

Open Access 01-12-2017 | Case report

Incidental late diagnosis of cystic fibrosis following AH1N1 influenza virus pneumonia: a case report

Authors: Carlo Iadevaia, Paola Iacotucci, Vincenzo Carnovale, Cecilia Calabrese, Gaetano Rea, Nicola Ferrara, Fabio Perrotta, Gennaro Mazzarella, Andrea Bianco

Published in: Journal of Medical Case Reports | Issue 1/2017

Abstract

Background

Cystic fibrosis is an autosomal recessive disorder characterized by chronic progressive multisystem involvement. AH1N1 virus infections caused classic influenza symptoms in the majority of cystic fibrosis patients while others experienced severe outcomes.

Case presentation

We report a case of late incidental cystic fibrosis diagnosis in a young Caucasian man suffering from respiratory failure following infection due to AH1N1 influenza virus. The patient was admitted to our department with fever, cough, and dyspnea at rest unresponsive to antibiotics

Conclusions

Late diagnosis of cystic fibrosis in uncommon. This report highlights the importance of early cystic fibrosis diagnosis to minimize risk of occurrence of potential life-threatening complications.

Rowe SM, Miller S, Sorscher EJ. Cystic fibrosis. N Engl J Med. 2005;352:1992–2001.CrossRefPubMed

Coffey MJ, Whitaker V, Gentin N, Junek R, Shalhoub C, Nightingale S, Hilton J, Wiley V, Wilcken B, Gaskin KJ, Ooi CY. Differences in outcomes between early and late diagnosis of cystic fibrosis in the newborn screening era. J Pediatr. 2017;181:137–45. e1.CrossRefPubMed

Santos V, Cardoso AV, Lopes C, Azevedo P, Gamboa F, Amorim A. Cystic fibrosis - Comparison between patients in paediatric and adult age. Rev Port Pneumol. 2017;23(1):17–21.PubMed

Rosenstein BJ, Zeitlin PL. Cystic fibrosis. Lancet. 1998;351:277–82.CrossRefPubMed

Laurans M, Arion A, Fines-Guyon M, Regeasse A, Brouard J, Leclercq R, Duhamel JF. Pseudomonas aeruginosa and cystic fibrosis: first colonization to chronic infection. Arch Pediatr. 2006;13(Suppl1):S22–9.PubMed

Whiteman SC, Bianco A, Knight RA, Spiteri MA. Human rhinovirus selectively modulates membranous and soluble forms of its intercellular adhesion molecule-1 (ICAM-1) receptor to promote epithelial cell infectivity. J Biol Chem. 2003;278:11954–961.CrossRefPubMed

Bianco A, Sethi SK, Allen JT, Knight RA, Spiteri MA. Th2 cytokines exert a dominant influence on epithelial cell expression of the major group human rhinovirus receptor, ICAM-1. Eur Respir J. 1998;12:619–26.CrossRefPubMed

Viviani L, Assael BM, Kerem E. Impact of the A (H1N1) pandemic influenza (season 2009-2010) on patients with cystic fibrosis. J Cyst Fibros. 2011;10:370–6.CrossRefPubMed

Writing Committee of the WHO Consultation on Clinical Aspects of Pandemic (H1N1) 2009 Influenza, Bautista E, Chotpitayasunondh T, Gao Z, Harper SA, Shaw M, Uyeki TM, Zaki SR, Hayden FG, Hui DS, Kettner JD, Kumar A, Lim M, Shindo N, Penn C, Nicholson KG. Clinical aspects of pandemic 2009 influenza A (H1N1) virus infection. N Engl J Med. 2010;362(18):1708–19.CrossRef

10.

Bianco A, Parrella R, Esposito V, Mazzarella G, Sammarco ML, Brunese L, Ripabelli G. Severe A(H1N1)-associated pneumonia sequential to Clamidophila pneumoniae infection in Healthy Subject. In Vivo. 2011;25(5):825–8.PubMed

11.

Giannattasio A, Brunese L, Ripabelli G, Mazzarella G, Bianco A. Coinfections with influenza virus and atypical bacteria: implications for severe outcomes? Clin Respir J. 2016. [Epub ahead of print].

12.

De Simone G, Aquino G, Di Gioia C, Mazzarella G, Bianco A, Calcagno G. Efficacy of aerobic physical retraining in a case of combined pulmonary fibrosis and emphysema syndrome: a case report. J Med Case Rep. 2015;9:85.CrossRefPubMedPubMedCentral

13.

Mazzarella G, Iadevaia C, Guerra G, Rocca A, Corcione N, Rossi G, Amore D, Brunese L, Bianco A. Intralobar pulmonary sequestration in an adult female patient mimicking asthma: a case report. Int J Surg. 2014;12 Suppl 2:S73–7.CrossRefPubMed

14.

Couriel J. Assessment of the child with recurrent chest infections. Br Med Bull. 2002;61:115–32.CrossRefPubMed

15.

Maniscalco M, Bianco A, Mazzarella G, Motta A. Recent advances on nitric oxide in the upper airways. Curr Med Chem. 2016;23(24):2736–45.CrossRefPubMed

16.

Brunese L, Greco B, Setola FR, Lassandro F, Guarracino MR, De Rimini M, Piccolo S, De Rosa N, Muto R, Bianco A, Muto P, Grassi R, Rotondo A. Non-small cell lung cancer evaluated with quantitative contrast-enhanced CT and PET-CT: net enhancement and standardized uptake values are related to tumour size and histology. Med Sci Monit. 2013;19:95–101.CrossRefPubMedPubMedCentral

17.

Bombieri C, Seia M, Castellani C. Genotypes and phenotypes in cystic fibrosis and cystic fibrosis transmembrane regulator-related disorders. Semin Respir Crit Care Med. 2015;36:180–93.16.CrossRefPubMed

18.

Bianco A, Mazzarella G, Turchiarelli V, Nigro E, Corbi G, Scudiero O, Sofia M, Daniele A. Adiponectin: an attractive marker for metabolic disorders in chronic obstructive pulmonary disease (COPD). Nutrients. 2013;5(10):4115–25.CrossRefPubMedPubMedCentral

19.

Bianco A, Nigro E, Monaco ML, Matera MG, Scudiero O, Mazzarella G, Daniele A. The burden of obesity in asthma and COPD: role of adiponectin. Pulm Pharmacol Ther. 2017;43:20–5.CrossRefPubMed

20.

Nigro E, Daniele A, Scudiero O, Ludovica Monaco M, Roviezzo F, D'Agostino B, Mazzarella G, Bianco A. Adiponectin in asthma: implications for phenotyping. Curr Protein Pept Sci. 2015;16(3):182–7.CrossRefPubMed

21.

Nigro E, Scudiero O, Sarnataro D, Mazzarella G, Sofia M, Bianco A, Daniele A. Adiponectin affects lung epithelial A549 cell viability counteracting TNFα and IL-1ß toxicity through AdipoR1. Int J Biochem Cell Biol. 2013;45(6):1145–53.CrossRefPubMed

22.

Renk H, Regamey N, Hartl D. Influenza A(H1N1)pdm09 and cystic fibrosis lung disease: a systematic meta-analysis. PLoS One. 2014;9(3):e93142.CrossRef

23.

Colombo C, Battezzati PM, Lucidi V, Magazzu G, Motta V, et al. Influenza A/H1N1 in patients with cystic fibrosis in Italy: a multicentre cohort study. Thorax. 2011;66:260–1.CrossRefPubMed

24.

France MW, Tai S, Masel PJ, Moore VL, McMahon TL, et al. The month of July: an early experience with pandemic influenza A (H1N1) in adults with cystic fibrosis. BMC Pulm Med. 2010;10:8.CrossRefPubMedPubMedCentral

Title: Incidental late diagnosis of cystic fibrosis following AH1N1 influenza virus pneumonia: a case report
Authors: Carlo Iadevaia
Paola Iacotucci
Vincenzo Carnovale
Cecilia Calabrese
Gaetano Rea
Nicola Ferrara
Fabio Perrotta
Gennaro Mazzarella
Andrea Bianco
Publication date: 01-12-2017
Publisher: BioMed Central
Published in: Journal of Medical Case Reports / Issue 1/2017
Electronic ISSN: 1752-1947
DOI: https://doi.org/10.1186/s13256-017-1430-0

At a glance: The STEP trials

Springer Medicine

Incidental late diagnosis of cystic fibrosis following AH1N1 influenza virus pneumonia: a case report

Abstract

Background

Case presentation

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Background

Case presentation

Conclusions

Please log in to get access to this content

Other articles of this Issue 1/2017

Stylistic features of case reports as a genre of medical discourse

Osteochondritis dissecans located on the medial tibial plateau: a case report

Isolated unilateral adrenal gland hemorrhage following motor vehicle collision: a case report and review of the literature

Isolated right ventricular thrombus in an adult patient with nephrotic syndrome: a case report

Unusual presentation of a severely ill patient having severe fever with thrombocytopenia syndrome: a case report

Visceral artery pseudoaneurysms: two case reports and a review of the literature