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Published in: Hernia 3/2018

01-06-2018 | Review

Incidence of chronic groin pain following open mesh inguinal hernia repair, and effect of elective division of the ilioinguinal nerve: meta-analysis of randomized controlled trials

Authors: M. P. Charalambous, C. P. Charalambous

Published in: Hernia | Issue 3/2018

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Abstract

Purpose

Chronic post-operative groin pain is a substantial complication following open mesh inguinal hernia repair. The exact cause of this pain is still unclear, but entrapment or trauma of the ilioinguinal nerve may have a role to play. Elective division of this nerve during hernia repair has been proposed in an attempt to reduce the incidence of chronic groin pain.

Methods

We performed a meta-analysis of nine randomized controlled trials comparing preservation versus elective division of the ilioinguinal nerve during this operation.

Results

A substantial proportion of patients having open mesh inguinal hernia repair experience chronic groin pain when the ilioinguinal nerve is preserved (estimated rate of 9.4% at 6 months and 4.8% at 1 year). Elective division of the nerve resulted in a significant reduction of groin pain at 6-months post-surgery (RR 0.47, p = 0.02), including moderate/severe pain (RR 0.57, p = 0.01). However, division of the nerve also resulted in an increase of subjective groin numbness at this time point (RR 1.55, p = 0.06). At 12-month post-surgery, the beneficial effect of nerve division on chronic pain was reduced, with no significant difference in the rates of overall groin pain (RR 0.69, p = 0.38), or of moderate-to-severe groin pain (RR 0.99, p = 0.98) between the two groups. The prevalence of groin numbness was also similar between the two groups at 12-month post-surgery (RR 0.79, p = 0.48).

Conclusions

Routine elective division of the ilioinguinal nerve during open mesh inguinal hernia repair does not significantly reduce chronic groin pain beyond 6 months, and may result in increased rates of groin numbness, especially in the first 6-months post-surgery.
Literature
2.
go back to reference Poobalan AS, Bruce J, Smith WC, King PM, Krukowski ZH, Chambers WA (2003) A review of chronic pain after inguinal herniorrhaphy. Clin J Pain 19:48–54CrossRefPubMed Poobalan AS, Bruce J, Smith WC, King PM, Krukowski ZH, Chambers WA (2003) A review of chronic pain after inguinal herniorrhaphy. Clin J Pain 19:48–54CrossRefPubMed
3.
go back to reference Cunningham J, Temple WJ, Mitchell P, Nixon JA, Preshaw RM, Hagen NA (1996) Cooperative hernia study. Pain in the postrepair patient. Ann Surg 224:598–602CrossRefPubMedPubMedCentral Cunningham J, Temple WJ, Mitchell P, Nixon JA, Preshaw RM, Hagen NA (1996) Cooperative hernia study. Pain in the postrepair patient. Ann Surg 224:598–602CrossRefPubMedPubMedCentral
4.
go back to reference Kehlet H, Jensen TS, Woolf CJ (2006) Peristent postsurgical pain: risk factors and prevention. Lancet 367:1618–1625CrossRefPubMed Kehlet H, Jensen TS, Woolf CJ (2006) Peristent postsurgical pain: risk factors and prevention. Lancet 367:1618–1625CrossRefPubMed
5.
go back to reference Ndiaye A, Diop M, Ndoye JM, Konaté I, Ndiaye AI, Mané L, Nazarian S, Dia A (2007) Anatomical basis of neuropathies and damage of the ilioinguinal nerve during repairs of groin hernias (about 100 dissections). Surg Radiol Anat 29:675–681CrossRefPubMed Ndiaye A, Diop M, Ndoye JM, Konaté I, Ndiaye AI, Mané L, Nazarian S, Dia A (2007) Anatomical basis of neuropathies and damage of the ilioinguinal nerve during repairs of groin hernias (about 100 dissections). Surg Radiol Anat 29:675–681CrossRefPubMed
6.
go back to reference Dittrick GW, Ridl K, Kuhn JA, McCarty TM (2004) Routine ilioinguinal nerve excision in inguinal hernia repairs. Am J Surg 188:736–740CrossRefPubMed Dittrick GW, Ridl K, Kuhn JA, McCarty TM (2004) Routine ilioinguinal nerve excision in inguinal hernia repairs. Am J Surg 188:736–740CrossRefPubMed
7.
go back to reference Madura JA, Madura JA 2nd, Copper CM, Worth RM (2005) Inguinal neurectomy for inguinal nerve entrapment: an experience with 100 patients. Am J Surg 189:283–287CrossRefPubMed Madura JA, Madura JA 2nd, Copper CM, Worth RM (2005) Inguinal neurectomy for inguinal nerve entrapment: an experience with 100 patients. Am J Surg 189:283–287CrossRefPubMed
8.
go back to reference Wijsmuller AR, van Veen RN, Bosch JL, Lange JFM, Kleinrensink GJ, Jeekel J, Lange JF (2007) Nerve management during open hernia repair. Br J Surg 94:17–22CrossRefPubMed Wijsmuller AR, van Veen RN, Bosch JL, Lange JFM, Kleinrensink GJ, Jeekel J, Lange JF (2007) Nerve management during open hernia repair. Br J Surg 94:17–22CrossRefPubMed
9.
go back to reference Padulo J, Olivia F, Frizziero A, Maffulli N (2013) Basic principles and recommendations in clinical and field science. MLTJ 4:250–252 Padulo J, Olivia F, Frizziero A, Maffulli N (2013) Basic principles and recommendations in clinical and field science. MLTJ 4:250–252
10.
go back to reference Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17:1–12CrossRefPubMed Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ (1996) Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17:1–12CrossRefPubMed
11.
go back to reference Kjaergard LL, Villumsen J, Gluud C (2001) Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses. Ann Intern Med 135:982–989CrossRefPubMed Kjaergard LL, Villumsen J, Gluud C (2001) Reported methodologic quality and discrepancies between large and small randomized trials in meta-analyses. Ann Intern Med 135:982–989CrossRefPubMed
12.
go back to reference Moher D, Pham B, Jones A, Cook DJ, Jadad AR, Moher M et al (1998) Does quality of reports of randomized trials affect estimates of intervention efficacy reported in meta-analyses? Lancet 352:609–613CrossRefPubMed Moher D, Pham B, Jones A, Cook DJ, Jadad AR, Moher M et al (1998) Does quality of reports of randomized trials affect estimates of intervention efficacy reported in meta-analyses? Lancet 352:609–613CrossRefPubMed
13.
go back to reference Ravichandran D, Kalambe BG, Pain JA (2000) Pilot randomized controlled study of preservation or division of ilioinguinal nerve in open mesh repair of inguinal hernia. Br J Surg 87:1166–1167CrossRefPubMed Ravichandran D, Kalambe BG, Pain JA (2000) Pilot randomized controlled study of preservation or division of ilioinguinal nerve in open mesh repair of inguinal hernia. Br J Surg 87:1166–1167CrossRefPubMed
14.
go back to reference Picchio M, Palimento D, Attanasio U, Matarazzo PF, Bambini C, Caliendo A (2004) Randomized controlled trial of preservation or elective division of ilioinguinal nerve on open inguinal hernia repair with polypropylene mesh. Arch Surg 139:755–758CrossRefPubMed Picchio M, Palimento D, Attanasio U, Matarazzo PF, Bambini C, Caliendo A (2004) Randomized controlled trial of preservation or elective division of ilioinguinal nerve on open inguinal hernia repair with polypropylene mesh. Arch Surg 139:755–758CrossRefPubMed
15.
go back to reference Mui WL, Ng CS, Fung TM, Cheung FK, Wong CM, Ma TH et al (2006) Prophylactic ilioinguinal neurectomy in open inguinal hernia repair: a double-blind randomized controlled trial. Ann Surg 244:27–33CrossRefPubMed Mui WL, Ng CS, Fung TM, Cheung FK, Wong CM, Ma TH et al (2006) Prophylactic ilioinguinal neurectomy in open inguinal hernia repair: a double-blind randomized controlled trial. Ann Surg 244:27–33CrossRefPubMed
16.
go back to reference Karakayali F, Oksuz E, Turk E, Pekmez M, Karabulut Z, Yilmaz T, Moray G, Haberal M (2010) Effectiveness of multiple neurectomies to prevent chronic groin pain after tension-free hernia repair. Int Surg 95:40–48PubMed Karakayali F, Oksuz E, Turk E, Pekmez M, Karabulut Z, Yilmaz T, Moray G, Haberal M (2010) Effectiveness of multiple neurectomies to prevent chronic groin pain after tension-free hernia repair. Int Surg 95:40–48PubMed
17.
go back to reference Pulido-Cejudo A, Carrillo-Ruiz JD, Jalife-Montano A, Zaldivar-Ramirez FR, Hurtado-Lopez LM (2012) Inguinodynia in patients after inguinal hernioplasty with the Lichtenstein technique with resection of the ipsilateral ilioinguinal nerve. Circ Gen 34(1):18–24 Pulido-Cejudo A, Carrillo-Ruiz JD, Jalife-Montano A, Zaldivar-Ramirez FR, Hurtado-Lopez LM (2012) Inguinodynia in patients after inguinal hernioplasty with the Lichtenstein technique with resection of the ipsilateral ilioinguinal nerve. Circ Gen 34(1):18–24
18.
go back to reference Bansal A, Rabha S, Griwan M, Karthikeyan Y (2013) Comparative evaluation of preservation versus elective division of the ilioinguinal nerve in open mesh repair of inguinal hernias. Int J Surg 30(1):1–6 Bansal A, Rabha S, Griwan M, Karthikeyan Y (2013) Comparative evaluation of preservation versus elective division of the ilioinguinal nerve in open mesh repair of inguinal hernias. Int J Surg 30(1):1–6
19.
go back to reference Belim OB, Shah NJ, Patil MV (2014) Comparative study of preservation versus elective division of ileo inguinal nerve in open repair of inguinal hernia. IJCMAAS 2(3):14–21 Belim OB, Shah NJ, Patil MV (2014) Comparative study of preservation versus elective division of ileo inguinal nerve in open repair of inguinal hernia. IJCMAAS 2(3):14–21
20.
go back to reference Kudva A, Lakshminarayana B, Addala PK, Seetharama P (2016) A randomized control study on neurosensory outcomes of ilioinguinal neurectomy in Lichtenstein’s hernia repair. Arch Clin Exp Surg 5:94–99CrossRef Kudva A, Lakshminarayana B, Addala PK, Seetharama P (2016) A randomized control study on neurosensory outcomes of ilioinguinal neurectomy in Lichtenstein’s hernia repair. Arch Clin Exp Surg 5:94–99CrossRef
22.
go back to reference Tsakayannis DE, Kiriakopoulos AC, Linos DA (2004) Elective neurectomy during open, “tension free” inguinal hernia repair. Hernia 8:67–69CrossRefPubMed Tsakayannis DE, Kiriakopoulos AC, Linos DA (2004) Elective neurectomy during open, “tension free” inguinal hernia repair. Hernia 8:67–69CrossRefPubMed
23.
go back to reference Bartlett DC, Porter C, Kingsnorth AN (2007) A pragmatic approach to cutaneous nerve division during open inguinal hernia repair. Hernia 11:243–246CrossRefPubMed Bartlett DC, Porter C, Kingsnorth AN (2007) A pragmatic approach to cutaneous nerve division during open inguinal hernia repair. Hernia 11:243–246CrossRefPubMed
24.
go back to reference Crea N, Pata G (2010) Effects of prophylactic ilioinguinal nerve excision in mesh groin hernia repair: short- and long-term follow up of a randomized clinical trial. Am Surg 76(11):1275–1281PubMed Crea N, Pata G (2010) Effects of prophylactic ilioinguinal nerve excision in mesh groin hernia repair: short- and long-term follow up of a randomized clinical trial. Am Surg 76(11):1275–1281PubMed
26.
go back to reference Jatoi AH, Younus SM, Ghayassuddin M, Mirani AJ, Ghayas N, Qazi A, Suchdev S, Bakshi S (2014) Comparison after preservation and elective division of ilioinguinal nerve in inguinal hernioplasty. Prof M J 21(3):559–565 Jatoi AH, Younus SM, Ghayassuddin M, Mirani AJ, Ghayas N, Qazi A, Suchdev S, Bakshi S (2014) Comparison after preservation and elective division of ilioinguinal nerve in inguinal hernioplasty. Prof M J 21(3):559–565
27.
go back to reference Joshi A (2015) Prophylactic ilioinguinal neurectomy: can it prevent chronic groin pain after Lichtenstein inguinal hernia repair? J Kathmandu Med Coll 4(2):39–44CrossRef Joshi A (2015) Prophylactic ilioinguinal neurectomy: can it prevent chronic groin pain after Lichtenstein inguinal hernia repair? J Kathmandu Med Coll 4(2):39–44CrossRef
29.
go back to reference Tsirline VB, Colavita PD, Belyansky I, Zemlyak AY, Lincourt AE, Heniford BT (2013) Preoperative pain is the strongest predictor of postoperative pain and diminished quality of life after ventral hernia repair. Am Surg 79(8):829–836PubMed Tsirline VB, Colavita PD, Belyansky I, Zemlyak AY, Lincourt AE, Heniford BT (2013) Preoperative pain is the strongest predictor of postoperative pain and diminished quality of life after ventral hernia repair. Am Surg 79(8):829–836PubMed
30.
go back to reference Bischoff JM, Aasvang EK, Kehlet H, Werner MU (2012) Does nerve identification during open inguinal herniorrhaphy reduce the risk of nerve damage and persistent pain? Hernia 16(5):573–577CrossRefPubMed Bischoff JM, Aasvang EK, Kehlet H, Werner MU (2012) Does nerve identification during open inguinal herniorrhaphy reduce the risk of nerve damage and persistent pain? Hernia 16(5):573–577CrossRefPubMed
Metadata
Title
Incidence of chronic groin pain following open mesh inguinal hernia repair, and effect of elective division of the ilioinguinal nerve: meta-analysis of randomized controlled trials
Authors
M. P. Charalambous
C. P. Charalambous
Publication date
01-06-2018
Publisher
Springer Paris
Published in
Hernia / Issue 3/2018
Print ISSN: 1265-4906
Electronic ISSN: 1248-9204
DOI
https://doi.org/10.1007/s10029-018-1753-9

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