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International Journal of Colorectal Disease
Published in: International Journal of Colorectal Disease 6/2011

01-06-2011 | Original Article

In vivo validation of a therapy planning system for laser-induced thermotherapy (LITT) of liver malignancies

Authors: Kai Siegfried Lehmann, Bernd Benedikt Frericks, Christoph Holmer, Andrea Schenk, Andreas Weihusen, Verena Knappe, Urte Zurbuchen, Heinz Otto Peitgen, Heinz Johannes Buhr, Jörg Peter Ritz

Published in: International Journal of Colorectal Disease | Issue 6/2011

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Abstract

Purpose

In situ ablation is increasingly being used for the treatment of liver malignancies. The application of these techniques is limited by the lack of a precise prediction of the destruction volume. This holds especially true in anatomically difficult situations, such as metastases in the vicinity of larger liver vessels. We developed a three-dimensional (3D) planning system for laser-induced thermotherapy (LITT) of liver tumors. The aim of the study was to validate the system for calculation of the destruction volume.

Methods

LITT (28 W, 20 min) was performed in close contact to major hepatic vessels in six pigs. After explantation of the liver, the coagulation area was documented. The liver and its vascular structures were segmented from a pre-interventional CT scan. Therapy planning was carried out including the cooling effect of adjacent liver vessels. The lesions in vivo and the simulated lesions were compared with a morphometric analysis.

Results

The volume of lesions in vivo was 6,568.3 ± 3,245.9 mm3, which was not different to the simulation result of 6,935.2 ± 2,538.5 mm3 (P = 0.937). The morphometric analysis showed a sensitivity of the system of 0.896 ± 0.093 (correct prediction of destructed tissue). The specificity was 0.858 ± 0.090 (correct prediction of vital tissue).

Conclusions

A 3D computer planning system for the prediction of thermal lesions in LITT was developed. The calculation of the directional cooling effect of intrahepatic vessels is possible for the first time. The morphometric analysis showed a good correlation under clinical conditions. The pre-therapeutic calculation of the ablation zone might be a valuable tool for procedure planning.
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Metadata
Title
In vivo validation of a therapy planning system for laser-induced thermotherapy (LITT) of liver malignancies
Authors
Kai Siegfried Lehmann
Bernd Benedikt Frericks
Christoph Holmer
Andrea Schenk
Andreas Weihusen
Verena Knappe
Urte Zurbuchen
Heinz Otto Peitgen
Heinz Johannes Buhr
Jörg Peter Ritz
Publication date
01-06-2011
Publisher
Springer-Verlag
Published in
International Journal of Colorectal Disease / Issue 6/2011
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-011-1175-y

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