Published in:
Open Access
01-12-2015 | Walking poster presentation
In vivo multi-modality tracking of the regenerative effects of the human induced pluripotent stem cell-derived cardiomyocytes (iCMs)
Authors:
Morteza Mahmoudi, Eric Rulifson, Atsushi Tachibana, Mouer Wang, Joseph C Wu, Phillip Yang
Published in:
Journal of Cardiovascular Magnetic Resonance
|
Special Issue 1/2015
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Excerpt
In vivo multi-modality cellular and molecular imaging of the engrafted iCMs is necessary to characterize the engraftment and the regional effects on the viability of the injured myocardium. Zinc finger nuclease (ZFN)-mediated integration of the reporter gene into the AAVS1 locus in the iCMs and manganese enhanced MRI (MEMRI) should allow precise in vivo detection of myocardial regeneration. …