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European Radiology
Published in: European Radiology 6/2011

Open Access 01-06-2011 | Musculoskeletal

In vivo measures of cartilage deformation: patterns in healthy and osteoarthritic female knees using 3T MR imaging

Authors: Sebastian Cotofana, Felix Eckstein, Wolfgang Wirth, Richard B. Souza, Xiaojuan Li, Bradley Wyman, Marie-Pierre Hellio-Le Graverand, Thomas Link, Sharmila Majumdar

Published in: European Radiology | Issue 6/2011

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Abstract

Objective

To explore and to compare the magnitude and spatial pattern of in vivo femorotibial cartilage deformation in healthy and in osteoarthritic (OA) knees.

Methods

One knee each in 30 women (age: 55 ± 6 years; BMI: 28 ± 2.4 kg/m2; 11 healthy and 19 with radiographic femorotibial OA) was examined at 3Tesla using a coronal fat-suppressed gradient echo SPGR sequence. Regional and subregional femorotibial cartilage thickness was determined under unloaded and loaded conditions, with 50% body weight being applied to the knee in 20° knee flexion during imaging.

Results

Cartilage became significantly (p < 0.05) thinner during loading in the medial tibia (−2.7%), the weight-bearing medial femur (−4.1%) and in the lateral tibia (−1.8%), but not in the lateral femur (+0.1%). The magnitude of deformation in the medial tibia and femur tended to be greater in osteoarthritic knees than in healthy knees. The subregional pattern of cartilage deformation was similar for the different stages of radiographic OA.

Conclusion

Osteoarthritic cartilage tended to display greater deformation upon loading than healthy cartilage, suggesting that knee OA affects the mechanical properties of cartilage. The pattern of in vivo deformation indicated that cartilage loss in OA progression is mechanically driven.
Literature
1.
Lopez AD, Mathers CD, Ezzati M, Jamison DT, Murray CJ (2006) Global and regional burden of disease and risk factors, 2001: systematic analysis of population health data. Lancet 367:1747–1757PubMedCrossRef
2.
Englund M (2010) The role of biomechanics in the initiation and progression of OA of the knee. Best Pract Res Clin Rheumatol 24:39–46PubMedCrossRef
3.
Eckstein F, Maschek S, Wirth W et al (2009) One year change of knee cartilage morphology in the first release of participants from the Osteoarthritis Initiative progression subcohort: association with sex, body mass index, symptoms and radiographic osteoarthritis status. Ann Rheum Dis 68:674–679PubMedCrossRef
4.
Eckstein F, Hudelmaier M, Wirth W et al (2006) Double echo steady state magnetic resonance imaging of knee articular cartilage at 3 Tesla: a pilot study for the Osteoarthritis Initiative. Ann Rheum Dis 65:433–441PubMedCrossRef
5.
Eckstein F, Cicuttini F, Raynauld JP, Waterton JC, Peterfy C (2006) Magnetic resonance imaging (MRI) of articular cartilage in knee osteoarthritis (OA): morphological assessment. Osteoarthritis Cartilage 14(Suppl A):A46–A75PubMedCrossRef
6.
Wirth W, Hellio Le Graverand MP, Wyman BT et al (2009) Regional analysis of femorotibial cartilage loss in a subsample from the Osteoarthritis Initiative progression subcohort. Osteoarthritis Cartilage 17:291–297PubMedCrossRef
7.
Eckstein F, Tieschky M, Faber SC, Haubner M, Kolem H, Englmeier KH, Reiser M (1998) Effect of physical exercise on cartilage volume and thickness in vivo: MR imaging study. Radiology 207:243–248PubMed
8.
Eckstein F, Tieschky M, Faber S, Englmeier KH, Reiser M (1999) Functional analysis of articular cartilage deformation, recovery, and fluid flow following dynamic exercise in vivo. Anat Embryol Berl 200:419–424PubMedCrossRef
9.
Eckstein F, Lemberger B, Stammberger T, Englmeier KH, Reiser M (2000) Patellar cartilage deformation in vivo after static versus dynamic loading. J Biomech 33:819–825PubMedCrossRef
10.
Eckstein F, Lemberger B, Gratzke C, Hudelmaier M, Glaser C, Englmeier KH, Reiser M (2005) In vivo cartilage deformation after different types of activity and its dependence on physical training status. Ann Rheum Dis 64:291–295PubMedCrossRef
11.
Guilak F, Ratcliffe A, Lane N, Rosenwasser MP, Mow VC (1994) Mechanical and biochemical changes in the superficial zone of articular cartilage in canine experimental osteoarthritis. J Orthop Res 12:474–484PubMedCrossRef
12.
Arokoski JP, Jurvelin JS, Vaatainen U, Helminen HJ (2000) Normal and pathological adaptations of articular cartilage to joint loading. Scand J Med Sci Sports 10:186–198PubMedCrossRef
13.
Bi X, Yang X, Bostrom MP et al (2007) Fourier transform infrared imaging and MR microscopy studies detect compositional and structural changes in cartilage in a rabbit model of osteoarthritis. Anal Bioanal Chem 387:1601–1612PubMedCrossRef
14.
Bi X, Li G, Doty SB, Camacho NP (2005) A novel method for determination of collagen orientation in cartilage by Fourier transform infrared imaging spectroscopy (FT-IRIS). Osteoarthritis Cartilage 13:1050–1058PubMedCrossRef
15.
Saarakkala S, Julkunen P, Kiviranta P, Makitalo J, Jurvelin JS, Korhonen RK (2010) Depth-wise progression of osteoarthritis in human articular cartilage: investigation of composition, structure and biomechanics. Osteoarthritis Cartilage 18:73–81PubMedCrossRef
16.
Bank RA, Soudry M, Maroudas A, Mizrahi J, TeKoppele JM (2000) The increased swelling and instantaneous deformation of osteoarthritic cartilage is highly correlated with collagen degradation. Arthritis Rheum 43:2202–2210PubMedCrossRef
17.
Kiviranta P, Lammentausta E, Toyras J, Kiviranta I, Jurvelin JS (2008) Indentation diagnostics of cartilage degeneration. Osteoarthritis Cartilage 16:796–804PubMedCrossRef
18.
Milentijevic D, Torzilli PA (2005) Influence of stress rate on water loss, matrix deformation and chondrocyte viability in impacted articular cartilage. J Biomech 38:493–502PubMedCrossRef
19.
Maroudas AI (1976) Balance between swelling pressure and collagen tension in normal and degenerate cartilage. Nature 260:808–809PubMedCrossRef
20.
DeFrate LE, Sun H, Gill TJ, Rubash HE, Li G (2004) In vivo tibiofemoral contact analysis using 3D MRI-based knee models. J Biomech 37:1499–1504PubMedCrossRef
21.
Li G, Park SE, DeFrate LE, Schutzer ME, Ji L, Gill TJ, Rubash HE (2005) The cartilage thickness distribution in the tibiofemoral joint and its correlation with cartilage-to-cartilage contact. Clin Biomech Bristol Avon 20:736–744CrossRef
22.
Li G, DeFrate LE, Park SE, Gill TJ, Rubash HE (2005) In vivo articular cartilage contact kinematics of the knee: an investigation using dual-orthogonal fluoroscopy and magnetic resonance image-based computer models. Am J Sports Med 33:102–107PubMedCrossRef
23.
Komistek RD, Dennis DA, Mahfouz M (2003) In vivo fluoroscopic analysis of the normal human knee. Clin Orthop Relat Res 410:69–81PubMedCrossRef
24.
Kozanek M, Hosseini A, Liu F, Van de Velde SK, Gill TJ, Rubash HE, Li G (2009) Tibiofemoral kinematics and condylar motion during the stance phase of gait. J Biomech 42:1877–1884PubMedCrossRef
25.
Liu F, Kozanek M, Hosseini A, Van de Velde SK, Gill TJ, Rubash HE, Li G (2010) In vivo tibiofemoral cartilage deformation during the stance phase of gait. J Biomech 43:658–665PubMedCrossRef
26.
JH KELLGREN, Lawrence JS (1957) Radiological assessment of rheumatoid arthritis. Ann Rheum Dis 16:485–493CrossRef
27.
Altman RD, Hochberg M, Murphy WA Jr, Wolfe F, Lequesne M (1995) Atlas of individual radiographic features in osteoarthritis. Osteoarthritis Cartilage 3(Suppl A):3–70PubMed
28.
Eckstein F, Guermazi A, Roemer FW (2009) Quantitative MR imaging of cartilage and trabecular bone in osteoarthritis. Radiol Clin North Am 47:655–673PubMedCrossRef
29.
Bellamy N, Buchanan WW, Goldsmith CH, Campbell J, Stitt LW (1988) Validation study of WOMAC: a health status instrument for measuring clinically important patient relevant outcomes to antirheumatic drug therapy in patients with osteoarthritis of the hip or knee. J Rheumatol 15:1833–1840PubMed
30.
Kraus VB, Vail TP, Worrell T, McDaniel G (2005) A comparative assessment of alignment angle of the knee by radiographic and physical examination methods. Arthritis Rheum 52:1730–1735PubMedCrossRef
31.
Moreland JR, Bassett LW, Hanker GJ (1987) Radiographic analysis of the axial alignment of the lower extremity. J Bone Joint Surg Am 69:745–749PubMed
32.
Herberhold C, Faber S, Stammberger T et al (1999) In situ measurement of articular cartilage deformation in intact femoropatellar joints under static loading. J Biomech 32:1287–1295PubMedCrossRef
33.
Nishii T, Kuroda K, Matsuoka Y, Sahara T, Yoshikawa H (2008) Change in knee cartilage T2 in response to mechanical loading. J Magn Reson Imaging 28:175–180PubMedCrossRef
34.
Mayerhoefer ME, Welsch GH, Mamisch TC et al (2010) The in vivo effects of unloading and compression on T1-Gd (dGEMRIC) relaxation times in healthy articular knee cartilage at 3.0 Tesla. Eur Radiol 20:443–449PubMedCrossRef
35.
Eckstein F, Ateshian G, Burgkart R et al (2006) Proposal for a nomenclature for magnetic resonance imaging based measures of articular cartilage in osteoarthritis. Osteoarthritis Cartilage 14:974–983PubMedCrossRef
36.
Wirth W, Eckstein F (2008) A technique for regional analysis of femorotibial cartilage thickness based on quantitative magnetic resonance imaging. IEEE Trans Med Imaging 27:737–744PubMedCrossRef
37.
Hudelmaier M, Glaser C, Hohe J, Englmeier KH, Reiser M, Putz R, Eckstein F (2001) Age-related changes in the morphology and deformational behavior of knee joint cartilage. Arthritis Rheum 44:2556–2561PubMedCrossRef
38.
Buckwalter JA, Mankin HJ, Grodzinsky AJ (2005) Articular cartilage and osteoarthritis. Instr Course Lect 54:465–480PubMed
39.
Lorenzo P, Bayliss MT, Heinegard D (2004) Altered patterns and synthesis of extracellular matrix macromolecules in early osteoarthritis. Matrix Biol 23:381–391PubMedCrossRef
40.
Dunn TC, Lu Y, Jin H, Ries MD, Majumdar S (2004) T2 relaxation time of cartilage at MR imaging: comparison with severity of knee osteoarthritis. Radiology 232:592–598PubMedCrossRef
41.
Mosher TJ, Dardzinski BJ, Smith MB (2000) Human articular cartilage: influence of aging and early symptomatic degeneration on the spatial variation of T2–preliminary findings at 3T. Radiology 214:259–266PubMed
42.
Saarakkala S, Julkunen P, Kiviranta P, Makitalo J, Jurvelin JS, Korhonen RK (2010) Depth-wise progression of osteoarthritis in human articular cartilage: investigation of composition, structure and biomechanics. Osteoarthritis Cartilage 18:73–81PubMedCrossRef
43.
Eckstein F, Wirth W, Hudelmaier M et al (2008) Patterns of femorotibial cartilage loss in knees with neutral, varus, and valgus alignment. Arthritis Rheum 59:1563–1570PubMedCrossRef
44.
Le Graverand MP, Buck RJ, Wyman BT et al (2010) Change in regional cartilage morphology and joint space width in osteoarthritis participants versus healthy controls: a multicentre study using 3.0 Tesla MRI and Lyon-Schuss radiography. Ann Rheum Dis 69:155–162PubMedCrossRef
45.
Wirth W, Hellio Le Graverand MP, Wyman BT et al (2009) Regional analysis of femorotibial cartilage loss in a subsample from the Osteoarthritis Initiative progression subcohort. Osteoarthritis Cartilage 17:291–297PubMedCrossRef
46.
Guermazi A, Burstein D, Conaghan P, Eckstein F, Hellio Le Graverand-Gastineau MP, Keen H, Roemer FW (2008) Imaging in osteoarthritis. Rheum Dis Clin North Am 34:645–687PubMedCrossRef
47.
Mosher TJ, Dardzinski BJ (2004) Cartilage MRI T2 relaxation time mapping: overview and applications. Semin Musculoskelet Radiol 8:355–368PubMedCrossRef
48.
Burstein D, Gray M, Mosher T, Dardzinski B (2009) Measures of molecular composition and structure in osteoarthritis. Radiol Clin North Am 47:675–686PubMedCrossRef
49.
Eckstein F, Burstein D, Link TM (2006) Quantitative MRI of cartilage and bone: degenerative changes in osteoarthritis. NMR Biomed 19:822–854PubMedCrossRef
50.
Souza RB, Stehling C, Wyman BT et al (2010) The effects of acute loading on T1rho and T2 relaxation times of tibiofemoral articular cartilage. Osteoarthritis Cartilage 18(12):1557–1563
Metadata
Title
In vivo measures of cartilage deformation: patterns in healthy and osteoarthritic female knees using 3T MR imaging
Authors
Sebastian Cotofana
Felix Eckstein
Wolfgang Wirth
Richard B. Souza
Xiaojuan Li
Bradley Wyman
Marie-Pierre Hellio-Le Graverand
Thomas Link
Sharmila Majumdar
Publication date
01-06-2011
Publisher
Springer-Verlag
Published in
European Radiology / Issue 6/2011
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI
https://doi.org/10.1007/s00330-011-2057-y

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