Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Magnetic Resonance Materials in Physics, Biology and Medicine
Published in: Magnetic Resonance Materials in Physics, Biology and Medicine 1/2013

01-02-2013 | Review Article

In-vivo human brain molecular imaging with a brain-dedicated PET/MRI system

Authors: Zang Hee Cho, Young Don Son, Eun Jung Choi, Hang Keun Kim, Jeong Hee Kim, Sang Yoon Lee, Seiji Ogawa, Young Bo Kim

Published in: Magnetic Resonance Materials in Physics, Biology and Medicine | Issue 1/2013

Login to get access

Abstract

Advances in the new-generation of ultra-high-resolution, brain-dedicated positron emission tomography-magnetic resonance imaging (PET/MRI) systems have begun to provide many interesting insights into the molecular dynamics of the brain. First, the finely delineated structural information from ultra-high-field MRI can help us to identify accurate landmark structures, thereby making it easier to locate PET activation sites that are anatomically well-correlated with metabolic or ligand-specific organs in the neural structures in the brain. This synergistic potential of PET/MRI imaging is discussed in terms of neuroscience and neurological research from both translational and basic research perspectives. Experimental results from the hippocampus, thalamus, and brainstem obtained with 18F-fluorodeoxyglucose and 11C-3-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrile are used to demonstrate the potential of this new brain PET/MRI system.
Literature
1.
Lauterbur PC (1973) Image formation by induced local interactions: examples employing nuclear magnetic resonance. Nature 242(5394):190–191CrossRef
2.
Ter-Pogossian MM, Phelps ME, Hoffman EJ, Mullani NA (1975) Positron-emission transaxial tomograph for nuclear imaging (PETT). Radiology 114:89–98PubMed
3.
Cho ZH, Chan JK, Eriksson L (1976) Circular ring transverse axial positron camera for 3-dimensional reconstruction of radionuclides distribution. IEEE Trans Nucl Sci 23:613–622CrossRef
4.
Mansfield P (1977) Multi-planar image formation using NMR spin echoes. J Phys Chem Solids 10(3):L55–L58
5.
Phelps ME, Hoffman EJ, Huang SC, Kuhl DE (1978) ECAT: a new computerized tomographic imaging system for positron-emitting radiopharmaceuticals. J Nucl Med 19(6):635–647PubMed
6.
Cho ZH, Son YD, Kim HK, Kim KN, Oh SH, Han JY, Hong IK, Kim YB (2008) A fusion PET/MRI system with a high-resolution research tomograph-PET and ultra-high field 7.0-T MRI for the molecular-genetic imaging of the brain. Proteomics 8(6):1302–1323PubMedCrossRef
7.
Schmand M, Casey ME, Wienhard K, Eriksson L, Jones WF, Lenox M, Young JW, Baker K, Miller SD, Reed JH, Heiss WD, Nutt R (1999) HRRT a new high resolution LSO-PET research tomograph. J Nucl Med 40(5):76
8.
Eriksson L, Wienhard K, Eriksson M, Casey ME, Knoess C, Bruckbauer T, Hamill J, Schmand M, Gremillion T, Lenox M, Conti M, Bendriem B, Heiss WD, Nutt R (2002) The ECAT HRRT: NEMA NEC evaluation of the HRRT system, the new high-resolution research tomograph. IEEE Trans Nucl Sci 49(5):2085–2088CrossRef
9.
Wienhard K, Schmand M, Casey ME, Baker K, Bao J, Eriksson L, Jones WF, Knoess C, Lenox M, Lercher M, Luk P, Michel C, Reed JH, Richerzhagen N, Treffert J, Vollmar S, Young JW, Heiss WD, Nutt R (2002) The ECAT HRRT: performance and first clinical application of the new high resolution research tomograph. IEEE Trans Nucl Sci 49(1):104–110CrossRef
10.
de Jong HW, van Velden FH, Kloet RW, Buijs FL, Boellaard R, Lammertsma AA (2007) Performance evaluation of the ECAT HRRT: an LSO-LYSO double layer high resolution, high sensitivity scanner. Phys Med Biol 52(5):1505–1526PubMedCrossRef
11.
Vaughan JT, Garwood M, Collins CM, Liu W, DelaBarre L, Adriany G, Andersen P, Merkle H, Goebel R, Smith MB, Ugurbil K (2001) 7T vs. 4T: RF power, homogeneity, and signal-to-noise comparison in head images. Magn Reson Med 46(1):24–30PubMedCrossRef
12.
Schmitt F, Grosu D, Mohr C, Purdy D, Salem K, Scott KT, Stoeckel B (2004) 3 Tesla MRI: successful results with higher field strengths. Radiologe 44(1):31–47PubMedCrossRef
13.
Cho ZH, Oh SH, Kim JM, Park SY, Kwon DH, Jeong HJ, Kim YB, Chi JG, Park CW, Huston J III, Lee KH, Jeon BS (2011) Direct visualization of Parkinson’s disease by in vivo human brain imaging using 7.0-T magnetic resonance imaging. Mov Disord 26(4):713–718PubMedCrossRef
14.
Cho ZH, Son YD, Kim HK, Kim NB, Choi EJ, Lee SY, Chi JG, Park CW, Kim YB, Ogawa S (2011) Observation of glucose metabolism in the thalamic nuclei by fusion PET/MRI. J Nucl Med 52(3):401–404PubMedCrossRef
15.
Cho ZH, Han JY, Hwang SI, Kim DS, Kim KN, Kim NB, Kim SJ, Chi JG, Park CW, Kim YB (2010) Quantitative analysis of the hippocampus using images obtained from 7.0-T MRI. Neuroimage 49(3):2134–2140PubMedCrossRef
16.
Cho ZH, Son YD, Kim HK, Kim ST, Lee SY, Chi JG, Park CW, Kim YB (2010) Substructural hippocampal glucose metabolism observed on PET/MRI. J Nucl Med 51(10):1545–1548PubMedCrossRef
17.
Cho ZH, Kang CK, Han JY, Kim SH, Kim KN, Hong SM, Park CW, Kim YB (2008) Observation of the lenticulostriate arteries in the human brain in vivo using 7.0 T MR angiography. Stroke 39(5):1604–1606PubMedCrossRef
18.
Kinahan PE, Townsend DW, Beyer T, Sashin D (1998) Attenuation correction for a combined 3D PET/CT scanner. Med Phys 25(10):2046–2053PubMedCrossRef
19.
Beyer T, Townsend DW, Brun T, Kinahan PE, Charron M, Roddy R, Jerin J, Young J, Byars L, Nutt R (2000) A combined PET/CT scanner for clinical oncology. J Nucl Med 41(8):1369–1379PubMed
20.
Hany TF, Steinert HC, Goerres GW, Buck A, von Schulthess GK (2002) PET diagnostic accuracy: improvement with in-line PET-CT system: initial results. Radiology 225:575–581PubMedCrossRef
21.
Bar-Shalom R, Yefremov N, Guralnik L, Gaitini D, Frenkel A, Kuten A, Altman H, Keidar Z, Israel O (2003) Clinical performance of PET/CT in evaluation of cancer: additional value for diagnostic imaging and patient management. J Nucl Med 44(8):1200–1209PubMed
22.
Pietrzyk U, Herholz K, Schuster A, von Stockhausen HM, Lucht H, Heiss WD (1996) Clinical applications of registration and fusion of multimodality brain images from PET, SPECT, CT, and MRI. Eur J Radiol 21(3):174–182PubMedCrossRef
23.
Borgwardt L, Højgaard L, Carstensen H, Laursen H, Nowak M, Thomsen C, Schmiegelow K (2005) Increased fluorine-18 2-fluoro-2-deoxy-d-glucose (FDG) uptake in childhood CNS tumors is correlated with malignancy grade: a study with FDG positron emission tomography/magnetic resonance imaging coregistration and image fusion. J Clin Oncol 23(13):3030–3037PubMedCrossRef
24.
Scoville WB, Milner B (1957) Loss of recent memory after bilateral hippocampal lesions. J Neurol Neurosurg Psychiatry 20:11–21PubMedCrossRef
25.
Maguire E (1998) Knowing where and getting there: a human navigation network. Science 280:921–924PubMedCrossRef
26.
Burgess N, Maguire E, O’Keefe J (2002) The human hippocampus and spatial and episodic memory. Neuron 35:625–641PubMedCrossRef
27.
Blum KI, Abbott LF (1996) A model of spatial map formation in the hippocampus of the rat. Neural Comput 8:85–93PubMedCrossRef
28.
Wieshmann UC, Symms MR, Mottershead JP, MacManus DG, Barker GJ, Tofts PS, Revesz T, Stevens JM, Shorvon SD (1999) Hippocampal layers on high resolution magnetic resonance images: real or imaginary? J Anat 195(1):131–135PubMedCrossRef
29.
Fischl B, Wald LL (2007) Phase maps reveal cortical architecture. Proc Natl Acad Sci USA 104(28):11513–11514PubMedCrossRef
30.
Mai JK, Assheuer J, Paxinos G (1997) Atlas of the human brain. Academic Press, San Diego
31.
Son YD, Cho ZH, Kim HK, Choi EJ, Lee SY, Chi JG, Park CW, Kim YB (2012) Glucose metabolism of the midline nuclei raphe in the brainstem observed by PET/MRI fusion imaging. Neuroimage 59(2):1094–1097PubMedCrossRef
32.
Ichise M, Liow JS, Lu JQ, Takano A, Model K, Toyama H, Suhara T, Suzuki K, Innis RB, Carson RE (2003) Linearized reference tissue parametric imaging methods: application to [11C]DASB positron emission tomography studies of the serotonin transporter in human brain. J Cereb Blood Flow Metab 23:1096–1112PubMedCrossRef
33.
Kim JS, Ichise M, Sangare J, Innis RB (2006) PET imaging of serotonin transporters with [11C]DASB: test-retest reproducibility using a multilinear reference tissue parametric imaging method. J Nucl Med 47:208–214PubMed
34.
Li Y, Rinne JO, Mosconi L, Pirraglia E, Rusinek H, DeSanti S, Kemppainen N, Någren K, Kim BC, Tsui W (2008) Regional analysis of FDG and PIB-PET images in normal aging, mild cognitive impairment, and Alzheimer’s disease. Eur J Nucl Med Mol Imaging 35(12):2169–2181PubMedCrossRef
35.
Naidich TP, Duvernoy HM, Delman BN, Sorensen AG, Kolias SS, Haacke EM (2009) Duvernoy’s Atlas of the human brain stem and cerebellum. Springer, WienCrossRef
36.
Heiss WD, Habedank B, Klein JC, Herholz K, Wienhard K, Lenox M, Nutt R (2004) Metabolic rates in small brain nuclei determined by high-resolution PET. J Nucl Med 45(11):181137
37.
Saulin A, Savli M, Lanzenberger R (2012) Serotonin and molecular neuroimaging in humans using PET. Amino Acids 42(6):2039–2057PubMedCrossRef
Metadata
Title
In-vivo human brain molecular imaging with a brain-dedicated PET/MRI system
Authors
Zang Hee Cho
Young Don Son
Eun Jung Choi
Hang Keun Kim
Jeong Hee Kim
Sang Yoon Lee
Seiji Ogawa
Young Bo Kim
Publication date
01-02-2013
Publisher
Springer-Verlag
Published in
Magnetic Resonance Materials in Physics, Biology and Medicine / Issue 1/2013
Print ISSN: 0968-5243
Electronic ISSN: 1352-8661
DOI
https://doi.org/10.1007/s10334-012-0329-4

Other articles of this Issue 1/2013

Magnetic Resonance Materials in Physics, Biology and Medicine 1/2013 Go to the issue

Research Article

Quantitative accuracy of attenuation correction in the Philips Ingenuity TF whole-body PET/MR system: a direct comparison with transmission-based attenuation correction

EditorialNotes

MR/PET or PET/MRI: does it matter?

Review Article

Does PET/MR in human brain imaging provide optimal co-registration? A critical reflection

Review Article

Radiotracers for positron emission tomography imaging

Review Article

Physical and organizational provision for installation, regulatory requirements and implementation of a simultaneous hybrid PET/MR-imaging system in an integrated research and clinical setting

Review Article

PET/MRI in cancer patients: first experiences and vision from Copenhagen