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Osteoporosis International
Published in: Osteoporosis International 5/2004

01-05-2004 | Original Article

In vivo application of 3D-line skeleton graph analysis (LSGA) technique with high-resolution magnetic resonance imaging of trabecular bone structure

Authors: Laurent Pothuaud, David C. Newitt, Ying Lu, Brian MacDonald, Sharmila Majumdar

Published in: Osteoporosis International | Issue 5/2004

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Abstract

Over the last several years magnetic resonance (MR) imaging has emerged as a means of measuring in vivo 3D trabecular bone structure. In particular, MR based diagnosis could be used to complement standard bone mineral density (BMD) methods for assessing osteoporosis and evaluating longitudinal changes. The aim of this study was to demonstrate the feasibility of using the 3D-LSGA technique for the evaluation of trabecular bone structure of high-resolution MR images, particularly for assessing longitudinal changes, in vivo. First, the reproducibility of topological 3D-LSGA based measurements was evaluated in a set of seven volunteers, and coefficients of variations ranged from 3.5% to 6%. Second, high-resolution MR images of the radius in 30 postmenopausal women from a placebo controlled drug study (Idoxifene), divided into placebo (n=9) and treated (n=21) groups, were obtained at baseline (BL) and after 1 year of treatment (follow-up, FU). In addition, dual X-ray absorptiometry (DXA) measures of BMD were obtained in the distal radius. Standard morphological measurements based on the mean intercept length (MIL) technique as well as 3D-LSGA based measurements were applied to the 3D MR images. Significant changes from BL to FU were detected, in the treated group, using the topological 3D-LSGA based measurements, morphological measures of volume of connected trabeculae and App Tb.N from MIL analysis. The duration of the study was short, and the number of patients remaining in the study was small, hence these results cannot be interpreted with regard to a true therapeutic response. Furthermore, the site (wrist) and the drug (idoxifene) are not optimal for follow-up study. However, this paper demonstrated the feasibility of using 3D-LSGA based evaluation coupled with in vivo high-resolution MR imaging as a complementary approach for the monitoring of trabecular bone changes in individual subjects.
Literature
1.
Pothuaud L, Majumdar S (2004) Assessment of trabecular bone structure and bone quality using magnetic resonance imaging. In: Langton CM, Njeh CF (eds) The physical measurement of bone (in press)
2.
Link TM, Saborowski Kisters K, Kempkes M et al. (2002) Changes in calcaneal trabecular bone structure assessed with high-resolution MR imaging in patients with kidney transplantation. Osteoporos Int 13:119–129CrossRef
3.
Wehrli FW, Hwang SN, Ma J et al. (1998) Cancellous bone volume and structure in the forearm: noninvasive assessment with MR microimaging and image processing [published erratum appears in Radiology 1998, 207:833]. Radiology 206:347–357PubMed
4.
Hwang SN, Wehrli FW (2002) Subvoxel processing: a method for reducing partial volume blurring with application to in vivo MR images of trabecular bone. Magn Reson Med 47:948–957CrossRefPubMed
5.
Majumdar S, Genant HK, Grampp S et al. (1997) Correlation of trabecular bone structure with age, bone mineral density, and osteoporotic status: in vivo studies in the distal radius using high resolution magnetic resonance imaging. J Bone Miner Res 12:111–118PubMed
6.
Vieth V, Link TM, Lotter A et al. (2001) Does the trabecular bone structure depicted by high-resolution MRI of the calcaneus reflect the true bone structure? Invest Radiol 36:210–217PubMed
7.
Pothuaud L, Laib A, Levitz P et al. (2002) 3D-line skeleton graph analysis of high-resolution magnetic resonance images: a validation study from 34-μm-resolution micro-computed tomography. J Bone Miner Res 17:1883–1895PubMed
8.
Majumdar S, Kothari M, Augat P et al. (1998) High-resolution magnetic resonance imaging: three-dimensional trabecular bone architecture and biomechanical properties. Bone 22:445–454PubMed
9.
Beuf O, Newitt DC, Mosekilde L et al. (2001) Trabecular structure assessment in lumbar vertebrae specimens using quantitative magnetic resonance imaging and relationship with mechanical competence. J Bone Miner Res 16:1511–1519PubMed
10.
Newitt DC, van Rietbergen B, Majumdar S (2002) Processing and analysis of in vivo high-resolution MR images of trabecular bone for longitudinal studies: reproducibility of structural measures and micro-finite element analysis derived mechanical properties. Osteoporos Int 13:278–287CrossRef
11.
Majumdar S, Link TM, Augat P et al. (1999) Trabecular bone architecture in the distal radius using magnetic resonance imaging in subjects with fractures of the proximal femur. Magnetic Resonance Science Center and Osteoporosis and Arthritis Research Group. Osteoporos Int 10:231–239PubMed
12.
Link TM, Majumdar S, Augat P et al. (1998) In vivo high resolution MRI of the calcaneus: differences in trabecular structure in osteoporosis patients. J Bone Miner Res 13:1175–1182PubMed
13.
Laib A, Newitt DC, Lu Y et al. (2002) New model-independent measures of trabecular bone structure applied to in vivo high-resolution MR images. Osteoporos Int 13:130–136CrossRef
14.
Pothuaud L, Newitt DC, Majumdar S (2001) Trabecular bone microarchitecture derived from high-resolution MRI of the ultradistal radius: relationship to osteoporotic status. Twenty-Third Annual Meeting of the ASBMR, Phoenix, Ariz., USA, M112
15.
Newitt DC, Majumdar S, Van Rietbergen B et al. (2002) In vivo assessment of architecture and micro-finite element analysis derived indices of mechanical properties of trabecular bone in the radius. Osteoporos Int 13:6–17CrossRef
16.
Link TM, Lotter A, Beyer F et al. (2000) Changes in calcaneal trabecular bone structure after heart transplantation: an MR imaging study. Radiology 217:855–862PubMed
17.
van Rietbergen B, Majumdar S, Newitt DC et al. (2002) High-resolution MRI and micro-FE for the evaluation of changes in bone mechanical properties during longitudinal clinical trials: application to calcaneal bone in postmenopausal women after one year of idoxifene treatment. Clin Biomech 17:81–88CrossRef
18.
Pothuaud L, Porion P, Lespessailles E et al. (2000) A new method for three-dimensional skeleton graph analysis of porous media: application to trabecular bone microarchitecture. J Microsc 199:149–161CrossRefPubMed
19.
http://www.hologic.com/prod-bd/pdf/spec-4500.pdf
20.
Hildebrand T, Ruegsegger P (1997) A new method for the model-independent assessment of thickness in three-dimensional images. J Microsc 185:67–75CrossRef
21.
Day JS, Ding M, Odgaard A et al. (2000) Parallel plate model for trabecular bone exhibits volume fraction-dependent bias. Bone 27:715–720CrossRefPubMed
22.
Hildebrand T, Laib A, Müller R et al. (1999) Direct three-dimensional morphometric analysis of human cancellous bone: microstructural data from spine, femur, iliac crest, and calcaneus. J Bone Miner Res 14:1167–1174PubMed
23.
Wehrli FW, Gomberg BR, Saha PK et al. (2001) Digital topological analysis of in vivo magnetic resonance microimages of trabecular bone reveals structural implications of osteoporosis. J Bone Miner Res 16:1520–1531PubMed
24.
Pothuaud L, van Rietbergen B, Mosekilde L et al. (2002) Combination of topological parameters and bone volume fraction better predicts the mechanical properties of trabecular bone. J Biomech 35:1091–1099CrossRefPubMed
25.
Pothuaud L, Levity P, Benhamou CL (2001) Simulation of osteoporosis bone changes: effects on the degree of anisotropy. Adv Exp Med Biol 496:111–121PubMed
26.
Pothuaud L, van Rietbergen B, Charlot C et al. (2004) A new computational efficient approach for trabecular bone analysis using beam models generated with skeletonized graph technique. Comp Meth Biomech Biomed Engng 1 (accepted)
Metadata
Title
In vivo application of 3D-line skeleton graph analysis (LSGA) technique with high-resolution magnetic resonance imaging of trabecular bone structure
Authors
Laurent Pothuaud
David C. Newitt
Ying Lu
Brian MacDonald
Sharmila Majumdar
Publication date
01-05-2004
Publisher
Springer-Verlag
Published in
Osteoporosis International / Issue 5/2004
Print ISSN: 0937-941X
Electronic ISSN: 1433-2965
DOI
https://doi.org/10.1007/s00198-003-1563-4

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