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BMC Anesthesiology
Published in: BMC Anesthesiology 1/2018

Open Access 01-12-2018 | Research article

In vitro investigation of the effects of exogenous sugammadex on coagulation in orthopedic surgical patients

Authors: Il Ok Lee, Young Sung Kim, Hae Wone Chang, Heezoo Kim, Byung Gun Lim, Mido Lee

Published in: BMC Anesthesiology | Issue 1/2018

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Abstract

Background

Previous studies have shown that sugammadex resulted in the prolongation of prothrombin time and activated partial thromboplastin time. In this study, we aimed to investigate the in vitro effects of exogenous sugammadex on the coagulation variables of whole blood in healthy patients who underwent orthopedic surgery.

Methods

The effects of sugammadex on coagulations were assessed using thromboelastography (TEG) in kaolin-activated citrated blood samples taken from 14 healthy patients who underwent orthopedic surgery. The in vitro effects of three different concentrations of sugammadex (42, 193, and 301 μg mL− 1) on the TEG profiles were compared with those of the control (0 μg mL− 1). Previous studies indicated that these exogenous concentrations correspond to the approximate maximum plasma concentrations achieved after the administration of 4, 16, and 32 mg kg− 1 sugammadex to healthy subjects.

Results

Increased sugammadex concentrations were significantly associated with reduced coagulation, as evidenced by increases in reaction time (r), coagulation time, and time to maximum rate of thrombus generation (TMRTG), and decreases in the angle, maximum amplitude, and maximum rate of thrombus generation. Compared with the control, the median percentage change (interquartile range) in the TEG values of the samples treated with the highest exogenous sugammadex concentration was the greatest for r, 53% (26, 67.3%), and TMRTG, 48% (26, 59%).

Conclusions

This in vitro study suggests that supratherapeutic doses of exogenous sugammadex might be associated with moderate hypocoagulation in the whole blood of healthy subjects.

Trial registration

identifier: UMIN000029081, registered 11 September 2017.
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Metadata
Title
In vitro investigation of the effects of exogenous sugammadex on coagulation in orthopedic surgical patients
Authors
Il Ok Lee
Young Sung Kim
Hae Wone Chang
Heezoo Kim
Byung Gun Lim
Mido Lee
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Anesthesiology / Issue 1/2018
Electronic ISSN: 1471-2253
DOI
https://doi.org/10.1186/s12871-018-0519-3

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