Top

Published in:

01-02-2015 | Melanomas

In-transit Melanoma Metastases: Incidence, Prognosis, and the Role of Lymphadenectomy

Authors: Georgia Beasley, Douglas Tyler

Published in: Annals of Surgical Oncology | Issue 2/2015

Excerpt

In this issue of Annals of Surgical Oncology, Read and colleagues describe a cohort analysis of the incidence, prognosis, and role of lymphadenectomy for in-transit (IT) melanoma. The study contributes to the large volume of clinical research this group has contributed to IT melanoma specifically and melanoma in general. The data they describe from a large prospectively maintained melanoma database can help clinicians understand this unusual presentation of stage 3 disease and also can be used to optimize treatment strategies for this patient population. …

Pawlik TM, Ross MI, Johnson MM, Schacherer CW, McClain DM, Mansfield PF, Lee JE, Cormier JN, Gershenwald JE. Predictors and natural history of in-transit melanoma after sentinel lymphadenectomy. Ann Surg Oncol. 2005;12:587–96. Epub 16 January 2005.PubMedCrossRef

Beasley GM, Speicher PJ, Sharma K, Jiang B, Salama AKS, Seigler H, Mosca PJ, Tyler DS. Efficacy of repeat sentinel lymph node biopsy for patients who develop recurrent melanoma. J Am Coll Surg. 2014;218:686–92. Epub 24 December 2013.PubMedCrossRef

Ariyan CE, Brady MS. History of regional chemotherapy for cancer of the extremities (review). Int J Hypertherm. 2008;24:185–92.CrossRef

Raymond AK, Beasley GM, Broadwater G, Augustine CK, Padussis JC, Turley R, Petersen B, Seigler H, Pruitt SK, Tyler DS. Current trends in regional therapy for melanoma: lessons learned from 225 regional chemotherapy treatments between 1995 and 2010 at a single institution. J Am Coll Surg. 2011;213:306–16. Epub 13 April 2011.PubMedCentralPubMedCrossRef

Jiang BS, Speicher PJ, Thomas S, Mosca PJ, Abernethy AP, Tyler DS. Quality of life after isolated limb infusion for in-transit melanoma of the extremity. Ann Surg Oncol. 2014. doi:10.1245/s10434-014-3979-9.

Sosman JA, Kim KB, Schuchter L, Gonzalez R, Pavlick AC, Weber JS, McArthur GA, Hutson TE, Moschos SJ, Flaherty KT, Hersey P, Kefford R, Lawrence D, Puzanov I, Lewis KD, Amaravadi RK, Chmielowski B, Lawrence HJ, Shyr Y, Ye F, Li J, Nolop KB, Lee RJ, Joe AK, Ribas A. Survival in BRAF V600-mutant advanced melanoma treated with vemurafenib. N Engl J Med. 2012;366:707–14.PubMedCentralPubMedCrossRef

Robert C, Thomas L, Bondarenko I, O’Day S, M D JW, Garbe C, Lebbe C, Baurain JF, Testori A, Grob JJ, Davidson N, Richards J, Maio M, Hauschild A, Miller WH Jr, Gascon P, Lotem M, Harmankaya K, Ibrahim R, Francis S, Chen TT, Humphrey R, Hoos A, Wolchok JD. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med. 2011;364:2517–26.

Toomey P, Kodumudi K, Weber A, Kuhn L, Moore E, Sarnaik AA, Pilon-Thomas S. Intralesional injection of Rose Bengal induces a systemic tumor-specific immune response in murine models of melanoma and breast cancer. PLoS One. 2013;8:e68561.PubMedCentralPubMedCrossRef

Jiang BS, Beasley GM, Speicher PJ, Mosca PJ, Morse MA, Hanks B, Salama A, Tyler DS. Immunotherapy following regional chemotherapy treatment of advanced extremity melanoma. Ann Surg Oncol. 2014;21:2525–31.PubMedCrossRef

10.

Ross MI. Intralesional therapy with PV-10 (Rose Bengal) for in-transit melanoma (review). J Surg Oncol. 2014;109:314–9. doi: 10.1002/jso.23554. Epub 10 February 2014.

11.

Olofsson R, Lindberg E, Karlsson-Parra A, Lindnér P, Mattsson J, Andersson B. Melan-A specific CD8 + T lymphocytes after hyperthermic isolated limb perfusion: a pilot study in patients with in-transit metastases of malignant melanoma. Int J Hypertherm. 2013;29:234–8.CrossRef

Title: In-transit Melanoma Metastases: Incidence, Prognosis, and the Role of Lymphadenectomy
Authors: Georgia Beasley
Douglas Tyler
Publication date: 01-02-2015
Publisher: Springer US
Published in: Annals of Surgical Oncology / Issue 2/2015
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI: https://doi.org/10.1245/s10434-014-4110-y

At a glance: The STEP trials

Springer Medicine

In-transit Melanoma Metastases: Incidence, Prognosis, and the Role of Lymphadenectomy

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 2/2015

Justified Follow-Up: A Final Intraoperative Parathyroid Hormone (ioPTH) Over 40 pg/mL is Associated with an Increased Risk of Persistence and Recurrence in Primary Hyperparathyroidism

Indeterminate Pulmonary Nodules in Colorectal-Cancer: Do Radiologists Agree?

Improved Survival in Osteosarcoma Patients with Atypical Low Vascularization

Positron Emission Tomography–Laparoscopy Based Method in the Prediction of Complete Cytoreduction in Platinum-Sensitive Recurrent Ovarian Cancer

Proposal of New Classification for Stage III Colon Cancer Based on the Lymph Node Ratio: Analysis of 4,172 Patients from Multi-Institutional Database in Japan

Surgical Treatment of Adenocarcinomas of the Gastro-esophageal Junction