Skip to main content
Top
Published in: Journal of Orthopaedic Surgery and Research 1/2024

Open Access 01-12-2024 | Implant Infection | Research article

Antibacterial activities of titanium dioxide (TiO2) nanotube with planar titanium silver (TiAg) to prevent orthopedic implant infection

Authors: Lihong Zhang, Zhihui Jin

Published in: Journal of Orthopaedic Surgery and Research | Issue 1/2024

Login to get access

Abstract

Background

Orthopedic implant infection has become a common catastrophic complication after various orthopedic implants, which can lead to prolonged use of antibiotics and even surgical failure. The quality of care (QoC) of orthopedic implant infection is very important.

Methods

Titanium dioxide (TiO2) nanotube array with planar TiAg was prepared, and their antibacterial rates were tested. 400 patients hospitalized in the Department of Orthopedics of Wuhan Fourth Hospital from May 2019 to May 2020 were selected as controls (before QoC evaluation system of orthopedics), and 400 patients hospitalized from June 2020 to June 2021 were selected as observation group (after QoC evaluation system of orthopedics).

Results

Regardless of Staphylococcus aureus or Escherichia coli, the antibacterial rate of TiO2 nanotube array with planar TiAg was clearly higher than that of pure iron film on the 10th and 20th days (P < 0.05). The accuracy of hospitalization assessment, disease assessment, adverse event intervention, nursing record filing and nursing satisfaction in observation group were higher as against controls (P < 0.05).

Conclusion

The TiO2 nanotube array with planar TiAg has good antibacterial property, which can effectively prevent orthopedic implant infection. The construction of QoC evaluation system for orthopedic specialists can effectively improve the QoC of orthopedic specialists.
Literature
1.
go back to reference Singh S, Chaurasia A, Gopal N, Malayeri A, Ball MW. Treatment strategies for hereditary kidney cancer: current recommendations and updates. Discov Med. 2022;34(173):205–20.PubMed Singh S, Chaurasia A, Gopal N, Malayeri A, Ball MW. Treatment strategies for hereditary kidney cancer: current recommendations and updates. Discov Med. 2022;34(173):205–20.PubMed
2.
go back to reference Liang JX, Chen L, Xu ZQ, Sun C, Peng WF, Cao X. Treadmill and wheel exercise protect against knee osteoarthritis in monosodium iodoacetate-induced knee osteoarthritis by inhibiting the ROS-mediate apoptosis pathway in mice. J Biol Regulat Homeost Agent. 2022;36(6):1939–46. Liang JX, Chen L, Xu ZQ, Sun C, Peng WF, Cao X. Treadmill and wheel exercise protect against knee osteoarthritis in monosodium iodoacetate-induced knee osteoarthritis by inhibiting the ROS-mediate apoptosis pathway in mice. J Biol Regulat Homeost Agent. 2022;36(6):1939–46.
3.
go back to reference Kumar A, Sinha N, Bhardwaj A, Goel S. Clinical risk assessment of chronic kidney disease patients using genetic programming. Comput Methods Biomech Biomed Eng. 2022;25(8):887–95.CrossRef Kumar A, Sinha N, Bhardwaj A, Goel S. Clinical risk assessment of chronic kidney disease patients using genetic programming. Comput Methods Biomech Biomed Eng. 2022;25(8):887–95.CrossRef
4.
go back to reference Han C, Jiang C, Yu C, Shen H. Differentiation of transforming growth factor Î21-induced mesenchymal stem cells into nucleus pulposus-like cells under simulated microgravity conditions. Cell Molr Biol (Noisy-le-grand). 2015;61(2):50–5. Han C, Jiang C, Yu C, Shen H. Differentiation of transforming growth factor Î21-induced mesenchymal stem cells into nucleus pulposus-like cells under simulated microgravity conditions. Cell Molr Biol (Noisy-le-grand). 2015;61(2):50–5.
5.
go back to reference Metsemakers WJ, Morgenstern M, McNally MA, Moriarty TF, McFadyen I, Scarborough M, Athanasou NA, Ochsner PE, Kuehl R, Raschke M, Borens O, Xie Z, Velkes S, Hungerer S, Kates SL, Zalavras C, Giannoudis PV, Richards RG, Verhofstad MHJ. Fracture-related infection: a consensus on definition from an international expert group. Injury. 2018;49(3):505–10.CrossRefPubMed Metsemakers WJ, Morgenstern M, McNally MA, Moriarty TF, McFadyen I, Scarborough M, Athanasou NA, Ochsner PE, Kuehl R, Raschke M, Borens O, Xie Z, Velkes S, Hungerer S, Kates SL, Zalavras C, Giannoudis PV, Richards RG, Verhofstad MHJ. Fracture-related infection: a consensus on definition from an international expert group. Injury. 2018;49(3):505–10.CrossRefPubMed
6.
go back to reference Wildemann B, Jandt KD. Infections @ trauma/orthopedic implants: recent advances on materials, methods, and microbes-a mini-review. Materials (Basel). 2021;14(19):5834.CrossRefPubMedPubMedCentralADS Wildemann B, Jandt KD. Infections @ trauma/orthopedic implants: recent advances on materials, methods, and microbes-a mini-review. Materials (Basel). 2021;14(19):5834.CrossRefPubMedPubMedCentralADS
7.
go back to reference Lex JR, Koucheki R, Stavropoulos NA, Michele JD, Toor JS, Tsoi K, Ferguson PC, Turcotte RE, Papagelopoulos PJ. Megaprosthesis anti-bacterial coatings: a comprehensive translational review. Acta Biomater. 2022;140:136–48.CrossRefPubMed Lex JR, Koucheki R, Stavropoulos NA, Michele JD, Toor JS, Tsoi K, Ferguson PC, Turcotte RE, Papagelopoulos PJ. Megaprosthesis anti-bacterial coatings: a comprehensive translational review. Acta Biomater. 2022;140:136–48.CrossRefPubMed
8.
go back to reference Bhardwaj H, Tomar P, Sakalle A, Ibrahim W. EEG-based personality prediction using fast fourier transform and DeepLSTM model. Comput Intell Neurosci. 2021;2021:6524858.CrossRefPubMedPubMedCentral Bhardwaj H, Tomar P, Sakalle A, Ibrahim W. EEG-based personality prediction using fast fourier transform and DeepLSTM model. Comput Intell Neurosci. 2021;2021:6524858.CrossRefPubMedPubMedCentral
9.
go back to reference Nakashima Y. The state of the Japanese Orthopedic Association during and after the COVID-19 pandemic. J Orthop Sci. 2022;27(1):1–2.CrossRefPubMed Nakashima Y. The state of the Japanese Orthopedic Association during and after the COVID-19 pandemic. J Orthop Sci. 2022;27(1):1–2.CrossRefPubMed
10.
go back to reference Al-Kulabi A, Mansour MA, Thahir A. The orthopaedic experience of COVID-19: a literature review. J Perioper Pract. 2021;31(3):102–7.PubMedPubMedCentral Al-Kulabi A, Mansour MA, Thahir A. The orthopaedic experience of COVID-19: a literature review. J Perioper Pract. 2021;31(3):102–7.PubMedPubMedCentral
11.
go back to reference Turukmane AT, Alhebaishi N, Alshareef AM, Mirza OM, Bhardwaj A, Singh B. Multispectral image analysis for monitoring by IoT based wireless communication using secure locations protocol and classification by deep learning techniques. Optik. 2022;271:170122.CrossRefADS Turukmane AT, Alhebaishi N, Alshareef AM, Mirza OM, Bhardwaj A, Singh B. Multispectral image analysis for monitoring by IoT based wireless communication using secure locations protocol and classification by deep learning techniques. Optik. 2022;271:170122.CrossRefADS
12.
go back to reference Abdelazeem AH, Khedr AM, Scarlat MM. Orthopaedic training during COVID-19 pandemic: should action be taken? Int Orthop. 2022;46(2):159–64.CrossRefPubMed Abdelazeem AH, Khedr AM, Scarlat MM. Orthopaedic training during COVID-19 pandemic: should action be taken? Int Orthop. 2022;46(2):159–64.CrossRefPubMed
13.
go back to reference Romanini E, Padua R, Tucci G, Zanoli G. Gruppo di Lavoro Ortopedia Basata su prove di Efficacia. Orthopedics between reason and passion. Guidelines and shadow lines. Recenti Prog Med. 2020;111(6):354–6.PubMed Romanini E, Padua R, Tucci G, Zanoli G. Gruppo di Lavoro Ortopedia Basata su prove di Efficacia. Orthopedics between reason and passion. Guidelines and shadow lines. Recenti Prog Med. 2020;111(6):354–6.PubMed
14.
go back to reference Kavolus JJ, Schwarzkopf R, Rajaee SS, Chen AF. Irrigation fluids used for the prevention and treatment of orthopaedic infections. J Bone Jt Surg Am. 2020;102(1):76–84.CrossRef Kavolus JJ, Schwarzkopf R, Rajaee SS, Chen AF. Irrigation fluids used for the prevention and treatment of orthopaedic infections. J Bone Jt Surg Am. 2020;102(1):76–84.CrossRef
15.
go back to reference Garcia DR, Deckey D, Haglin JM, Emanuel T, Mayfield C, Eltorai AEM, Spake CS, Jarrell JD, Born CT. Commonly encountered skin biome-derived pathogens after orthopedic surgery. Surg Infect (Larchmt). 2019;20(5):341–50.CrossRefPubMed Garcia DR, Deckey D, Haglin JM, Emanuel T, Mayfield C, Eltorai AEM, Spake CS, Jarrell JD, Born CT. Commonly encountered skin biome-derived pathogens after orthopedic surgery. Surg Infect (Larchmt). 2019;20(5):341–50.CrossRefPubMed
16.
go back to reference Stevenson MC, Slater JC, Sagi HC, Bedoya FP, Powers-Fletcher MV. Diagnosing fracture-related infections: where are we now? J Clin Microbiol. 2022;60(2):e0280720.CrossRefPubMed Stevenson MC, Slater JC, Sagi HC, Bedoya FP, Powers-Fletcher MV. Diagnosing fracture-related infections: where are we now? J Clin Microbiol. 2022;60(2):e0280720.CrossRefPubMed
17.
go back to reference Raja BS, Choudhury AK, Paul S, Rajkumar S, Kalia RB. Online educational resources for orthopaedic residency-a narrative review. Int Orthop. 2021;45(8):1911–22.CrossRefPubMed Raja BS, Choudhury AK, Paul S, Rajkumar S, Kalia RB. Online educational resources for orthopaedic residency-a narrative review. Int Orthop. 2021;45(8):1911–22.CrossRefPubMed
18.
go back to reference Ronin D, Boyer J, Alban N, Natoli RM, Johnson A, Kjellerup BV. Current and novel diagnostics for orthopedic implant biofilm infections: a review. APMIS. 2022;130(2):59–81.CrossRefPubMed Ronin D, Boyer J, Alban N, Natoli RM, Johnson A, Kjellerup BV. Current and novel diagnostics for orthopedic implant biofilm infections: a review. APMIS. 2022;130(2):59–81.CrossRefPubMed
19.
go back to reference Selmi H, Davies A, Walker J, Heaton T, Sabharwal S, Dani M, Fertleman M, Reilly P. Consent for orthopaedic trauma surgery during the COVID-19 pandemic. BMJ Open Qual. 2022;11(2):e001778.CrossRefPubMed Selmi H, Davies A, Walker J, Heaton T, Sabharwal S, Dani M, Fertleman M, Reilly P. Consent for orthopaedic trauma surgery during the COVID-19 pandemic. BMJ Open Qual. 2022;11(2):e001778.CrossRefPubMed
20.
go back to reference Yung CS, Fok KCH, Leung CN, Wong YW. What every orthopaedic surgeon should know about COVID-19: a review of the current literature. J Orthop Surg (Hong Kong). 2020;28(2):2309499020923499.CrossRefPubMed Yung CS, Fok KCH, Leung CN, Wong YW. What every orthopaedic surgeon should know about COVID-19: a review of the current literature. J Orthop Surg (Hong Kong). 2020;28(2):2309499020923499.CrossRefPubMed
21.
go back to reference Li Y, Wang S, Li S, Fei J. Clindamycin-loaded titanium prevents implant-related infection through blocking biofilm formation. J Biomater Appl. 2022;36(7):1231–42.CrossRefPubMed Li Y, Wang S, Li S, Fei J. Clindamycin-loaded titanium prevents implant-related infection through blocking biofilm formation. J Biomater Appl. 2022;36(7):1231–42.CrossRefPubMed
22.
go back to reference Wang W, Liu P, Zhang Q, Jiang G, Zheng H, Zhang W. Effect of high-quality nursing on orthopedic trauma based on a fast-track surgery model. Am J Transl Res. 2022;14(7):4812–20.PubMedPubMedCentral Wang W, Liu P, Zhang Q, Jiang G, Zheng H, Zhang W. Effect of high-quality nursing on orthopedic trauma based on a fast-track surgery model. Am J Transl Res. 2022;14(7):4812–20.PubMedPubMedCentral
Metadata
Title
Antibacterial activities of titanium dioxide (TiO2) nanotube with planar titanium silver (TiAg) to prevent orthopedic implant infection
Authors
Lihong Zhang
Zhihui Jin
Publication date
01-12-2024
Publisher
BioMed Central
Published in
Journal of Orthopaedic Surgery and Research / Issue 1/2024
Electronic ISSN: 1749-799X
DOI
https://doi.org/10.1186/s13018-024-04596-0

Other articles of this Issue 1/2024

Journal of Orthopaedic Surgery and Research 1/2024 Go to the issue