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European Journal of Pediatrics

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01-08-2013 | Original Article

Impaired endothelial function in female adolescents with type 1 diabetes measured by peripheral artery tonometry

Authors: Aagje Pareyn, Karel Allegaert, Willeke Asscherickx, Eva Peirsman, Peter Verhamme, Kristina Casteels

Published in: European Journal of Pediatrics | Issue 8/2013

Abstract

Background

The reactive hyperemia peripheral artery tonometry (RH-PAT) is a newly developed method for non-invasive endothelial function assessment.

Objective

The goal of this study is to determine whether a significant difference in RH-PAT score is present between adolescents with type 1 diabetes (T1D) in comparison with controls.

Subjects and methods

Thirty-four adolescents with T1D and 25 control subjects (age 12–20 years) underwent RH-PAT endothelial function testing after an overnight fast. Height, weight, body mass index (BMI), blood pressure (BP), fasting lipid profile, Tanner stage, and glucose level were determined in each child.

Results

Adolescents with T1D had significantly lower RH-PAT scores compared to healthy controls, and this difference remained significant when overweight cases were not considered (p < 0.05). This difference was also observed in the female subgroup (p = 0.005). The interindividual variability in RH-PAT observations in T1D cases was not explained by BMI standard deviation score (SDS), BP SDS, age, duration of T1D, hemoglobin A1c, triglycerides, and pubertal stage, respectively.

Conclusions

The RH-PAT technique is used as a non-invasive test to assess for early vascular changes in high-risk patient groups. Endothelial dysfunction, measured by RH-PAT, was present in diabetic adolescent, especially in the female subgroup. Although additional longitudinal studies are required, early detection of this reversible process may have therapeutic and prognostic implications.

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Title: Impaired endothelial function in female adolescents with type 1 diabetes measured by peripheral artery tonometry
Authors: Aagje Pareyn
Karel Allegaert
Willeke Asscherickx
Eva Peirsman
Peter Verhamme
Kristina Casteels
Publication date: 01-08-2013
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Pediatrics / Issue 8/2013
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-013-1988-5

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Springer Medicine

Impaired endothelial function in female adolescents with type 1 diabetes measured by peripheral artery tonometry

Abstract

Background

Objective

Subjects and methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Objective

Subjects and methods

Results

Conclusions

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