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Open Access 01-10-2015 | Original Article

Impact of time-of-flight on qualitative and quantitative analyses of myocardial perfusion PET studies using ¹³N-ammonia

Authors: Takeshi Tomiyama, MD, Keiichi Ishihara, MD, PhD, Masaya Suda, MS, Koji Kanaya, BS, Minoru Sakurai, BS, Naoto Takahashi, MD, PhD, Hitoshi Takano, MD, PhD, Koichi Nitta, BE, Kenta Hakozaki, MD, Shin-ichiro Kumita, MD, PhD

Published in: Journal of Nuclear Cardiology | Issue 5/2015

Abstract

Background

The impact of time-of-flight (TOF) in myocardial perfusion ¹³N-ammonia positron emission tomography (PET) is unclear.

Methods and Results

Twenty consecutive subjects underwent rest and adenosine stress ¹³N-ammonia myocardial perfusion PET. Two sets of images were reconstructed using TOF-ordered subset expectation maximization (TOF-OSEM) and 3-dimensional row-action maximum likelihood algorithm (3D-RAMLA). Qualitative and quantitative analyses from the TOF-OSEM and 3D-RAMLA reconstructions were compared. Count profile curves revealed that TOF relatively increased the uptake of ¹³N-ammonia at the lateral walls, and apical thinning was emphasized on the TOF images. Both segmental rest and stress myocardial blood flow (MBF) values were higher with TOF-OSEM use than with 3D-RAMLA use (rest MBF: 0.955 ± 0.201 vs 0.836 ± 0.185, P < .001; stress MBF: 2.149 ± 0.697 vs 2.058 ± 0.721, P < .001). The differentiation of MBF between reconstructions was more enhanced under rest conditions. Thus, segmental myocardial flow reserve (MFR) observed using TOF-OSEM reconstruction was lower than that observed using 3D-RAMLA (2.25 ± 0.57 vs 2.46 ± 0.75, P < .001). No remarkable differences were observed between segmental and territorial results.

Conclusions

TOF increased lateral wall counts and emphasized apical thinning. Quantitatively, TOF reconstruction showed increased MBF, especially under relatively low perfusion conditions.

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Title: Impact of time-of-flight on qualitative and quantitative analyses of myocardial perfusion PET studies using 13N-ammonia
Authors: Takeshi Tomiyama, MD
Keiichi Ishihara, MD, PhD
Masaya Suda, MS
Koji Kanaya, BS
Minoru Sakurai, BS
Naoto Takahashi, MD, PhD
Hitoshi Takano, MD, PhD
Koichi Nitta, BE
Kenta Hakozaki, MD
Shin-ichiro Kumita, MD, PhD
Publication date: 01-10-2015
Publisher: Springer US
Published in: Journal of Nuclear Cardiology / Issue 5/2015
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-014-0037-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Impact of time-of-flight on qualitative and quantitative analyses of myocardial perfusion PET studies using ¹³N-ammonia

Abstract

Background

Methods and Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods and Results

Conclusions

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