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Obesity Surgery

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Open Access 01-06-2011 | Physiology Research

Impact of Sustained Weight Loss Achieved through Roux-en-Y Gastric Bypass or a Lifestyle Intervention on Ghrelin, Obestatin, and Ghrelin/Obestatin Ratio in Morbidly Obese Patients

Authors: Catia Martins, Louise Kjelstrup, Ingrid L. Mostad, Bård Kulseng

Published in: Obesity Surgery | Issue 6/2011

Abstract

Background

Appetite-regulating hormones seem to play an important role in weight loss after bariatric surgery. Less is known regarding long-term weight loss maintenance. The objective of the study was to evaluate ghrelin and obestatin levels following long-term weight loss achieved through bariatric surgery or a lifestyle intervention in morbidly obese patients.

Methods

The study was cross-sectional in design carried out in a university research center setting. The participants were weight-stable morbidly obese patients who had undergone, on average, 3 years ago, Roux-en-Y gastric bypass (RYGB) surgery (n = 9) or a lifestyle weight loss intervention (n = 8), and patients on a waiting list for bariatric surgery (control group; n = 9). The main outcome measures were fasting/postprandial plasma levels of total ghrelin and obestatin and ghrelin/obestatin ratio.

Results

Fasting ghrelin and obestatin plasma levels were significantly elevated in the RYGB, but not in the lifestyle group, as compared with the control group. There was no statistical significant difference in fasting ghrelin/obestatin ratio among study groups. Ghrelin levels were suppressed after breakfast in all groups, with no significant differences in postprandial levels overtime between them. Obestatin levels did not change postprandially in any of the groups, but the area under the curve was significantly higher in the RYGB than in the control group.

Conclusions

Sustained weight loss maintenance seems to be associated with increased fasting levels of ghrelin and obestatin after RYGB surgery, but not after a lifestyle intervention, while maintaining ghrelin/obestatin ratio. Ghrelin is, therefore, unlikely to contribute to weight loss maintenance after RYGB, and other mechanisms are probably involved.

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Title: Impact of Sustained Weight Loss Achieved through Roux-en-Y Gastric Bypass or a Lifestyle Intervention on Ghrelin, Obestatin, and Ghrelin/Obestatin Ratio in Morbidly Obese Patients
Authors: Catia Martins
Louise Kjelstrup
Ingrid L. Mostad
Bård Kulseng
Publication date: 01-06-2011
Publisher: Springer-Verlag
Published in: Obesity Surgery / Issue 6/2011
Print ISSN: 0960-8923
Electronic ISSN: 1708-0428
DOI: https://doi.org/10.1007/s11695-011-0399-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Impact of Sustained Weight Loss Achieved through Roux-en-Y Gastric Bypass or a Lifestyle Intervention on Ghrelin, Obestatin, and Ghrelin/Obestatin Ratio in Morbidly Obese Patients

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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