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International Journal of Colorectal Disease

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01-01-2017 | Original Article

Impact of restless legs syndrome in patients with inflammatory bowel disease on sleep, fatigue, and quality of life

Authors: Katharina A. Schindlbeck, Janek Becker, Felix Berger, Arne Mehl, Charlotte Rewitzer, Sarah Geffe, Peter M. Koch, Jan C. Preiß, Britta Siegmund, Jochen Maul, Frank Marzinzik

Published in: International Journal of Colorectal Disease | Issue 1/2017

Abstract

Purpose

Inflammatory bowel disease has been associated with neurological symptoms including restless legs syndrome. Here, we investigated the impact of restless legs syndrome in patients with inflammatory bowel disease on sleep, fatigue, mood, cognition, and quality of life.

Methods

Two groups of inflammatory bowel disease patients, with and without restless legs syndrome, were prospectively evaluated for sleep disorders, fatigue, daytime sleepiness, depression, anxiety, and health-related quality of life. Furthermore, global cognitive function, executive function, attention, and concentration were assessed in both groups. Disease activity and duration of inflammatory bowel disease as well as current medication were assessed by interview. Inflammatory bowel disease patients with and without restless legs syndrome were matched for age, education, severity, and duration of their inflammatory bowel disease.

Results

Patients with inflammatory bowel disease and clinically relevant restless leg syndrome suffered significantly more frequent from sleep disturbances including sleep latency and duration, more fatigue, and worse health-related quality of life as compared to inflammatory bowel disease patients without restless legs syndrome. Affect and cognitive function including cognitive flexibility, attention, and concentration showed no significant differences among groups, indicating to be not related to restless legs syndrome.

Conclusions

Sleep disorders including longer sleep latency, shorter sleep duration, and fatigue are characteristic symptoms of restless legs syndrome in inflammatory bowel disease patients, resulting in worse health-related quality of life. Therefore, clinicians treating patients with inflammatory bowel disease should be alert for restless legs syndrome.

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Title: Impact of restless legs syndrome in patients with inflammatory bowel disease on sleep, fatigue, and quality of life
Authors: Katharina A. Schindlbeck
Janek Becker
Felix Berger
Arne Mehl
Charlotte Rewitzer
Sarah Geffe
Peter M. Koch
Jan C. Preiß
Britta Siegmund
Jochen Maul
Frank Marzinzik
Publication date: 01-01-2017
Publisher: Springer Berlin Heidelberg
Published in: International Journal of Colorectal Disease / Issue 1/2017
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI: https://doi.org/10.1007/s00384-016-2681-8

At a glance: The STEP trials

Springer Medicine

Impact of restless legs syndrome in patients with inflammatory bowel disease on sleep, fatigue, and quality of life

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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