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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 1/2018

01-01-2018 | Colorectal Cancer

Impact of RAS Mutations in Metastatic Colorectal Cancer After Potentially Curative Resection: Does Site of Metastases Matter?

Authors: Guillaume Passot, MD, PhD, Bradford J. Kim, MD, MHS, Olivier Glehen, MD, PhD, Reza J. Mehran, MD, Scott E. Kopetz, MD, Diane Goere, MD, PhD, Michael J. Overman, MD, Marc Pocard, MD, PhD, Frédéric Marchal, MD, PhD, Claudius Conrad, MD, PhD, Thomas A. Aloia, MD, Jean-Nicolas Vauthey, MD, Yun Shin Chun, MD, on behalf of the BIG-RENAPE Working Group

Published in: Annals of Surgical Oncology | Issue 1/2018

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Abstract

Background

RAS mutation status is an important prognostic factor after resection of liver metastases (LiM) from colorectal cancer (CRC). The prognostic significance of RAS after resection of lung (LuM) and peritoneal (PM) metastases from CRC is unknown.

Methods

Between 2005 and 2014, all consecutive patients with known RAS status who underwent potentially curative resection for LiM, LuM, or PM were evaluated.

Results

A total of 720 patients with known RAS status underwent resection of LiM (n = 468), LuM (n = 102), and PM (n = 150). RAS mutations were identified in 63 and 58% of patients with LuM and PM, respectively, compared with 41% of patients with LiM (p < 0.001). Five-year overall survival (OS) after resection of PM was 45%, compared with 52% after resection of LiM (p = 0.018) and 64% after resection of LuM (p = 0.005). RAS mutations were associated with significantly worse OS after resection of LiM (p < 0.001), but did not affect OS among patients undergoing resection of LuM (p = 0.41) and PM (p = 0.65).

Conclusions

RAS mutations are more prevalent among patients undergoing resection of LuM and PM than LiM but do not affect survival after lung and peritoneal metastasectomy, as they do after hepatectomy. These results suggest that the prognostic significance of RAS mutations after resection of metastatic CRC depends on the specific site of metastases.
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Metadata
Title
Impact of RAS Mutations in Metastatic Colorectal Cancer After Potentially Curative Resection: Does Site of Metastases Matter?
Authors
Guillaume Passot, MD, PhD
Bradford J. Kim, MD, MHS
Olivier Glehen, MD, PhD
Reza J. Mehran, MD
Scott E. Kopetz, MD
Diane Goere, MD, PhD
Michael J. Overman, MD
Marc Pocard, MD, PhD
Frédéric Marchal, MD, PhD
Claudius Conrad, MD, PhD
Thomas A. Aloia, MD
Jean-Nicolas Vauthey, MD
Yun Shin Chun, MD
on behalf of the BIG-RENAPE Working Group
Publication date
01-01-2018
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 1/2018
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-017-6141-7

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