Published in:
Open Access
01-02-2011 | Poster presentation
Impact of modulation of the endocannabinoid system on the intestinal microcirculation in experimental sepsis
Authors:
C Lehmann, R Kuschnereit, I Kiister, J Zhou, S Whynot, O Hung, R Shukla, D Henzler, V Cerny, D Pavlovic, M Kelly
Published in:
Critical Care
|
Special Issue 1/2011
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Excerpt
The endocannabinoid system (ECS) is upregulated during sepsis [
1]. However, the functional outcomes of modulating endocannabinoid signaling during sepsis are currently unclear. Impairment of the intestinal microcirculation during sepsis may cause a breakdown of gut epithelial barrier function and bacterial translocation into the systemic circulation, increasing the systemic inflammatory response [
2]. The aim of the present study was to examine the effects of CB1 and CB2 receptor modulation on the intestinal microcirculation in a model of polybacterial sepsis (colon ascendens stent peritonitis (CASP)) using intravital microscopy (IVM). …
