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Surgery Today

Published in:

01-11-2016 | Original Article

Impact of intermittent portal clamping on the early recurrence of hepatocellular carcinoma after surgery

Authors: Shenghua Hao, Shaofei Chen, Xiangwu Yang, Chidan Wan

Published in: Surgery Today | Issue 11/2016

Abstract

Purpose

To evaluate the impact of intermittent portal clamping (IPC) during surgery on the early recurrence of hepatocellular carcinoma (HCC).

Methods

The subjects of this retrospective study were 266 patients who underwent curative liver resection for HCC. The patients were grouped as follows: an intermittent portal clamping (IPC) group, n = 78; a continuous portal clamping (CPC) group, n = 128; and a non-portal clamping (NPC) group, n = 60.

Results

The median recurrence-free interval within 2 years of follow-up was significantly shorter in the IPC group (14.2 ± 4.6 months) than in the CPC group (18.0 ± 4.8 months, P = 0.008) or the NPC group (19.04 ± 4.1 months, P = 0.023). Moreover, 2-year recurrence-free survival was much lower in the IPC group than in the CPC group (63.6 vs. 75.8 %, P = 0.025) or the NPC group (63.6 vs. 78.0 %, P = 0.030). However, the 2-year OS rate among the three groups was comparable (72.7 vs. 79.9 %; P = 0.101) and 83.1 %, (P = 0.125). According to univariable analysis, tumor size (>5 cm), tumor number (≥2), tumor grade (low/undifferentiated), TNM stage (III), vascular infiltration, blood transfusion, and IPC were significantly associated with the early postoperative recurrence of HCC. After multivariate analysis, significance of tumor grade (low/undifferentiated) and TNM stage (III) disappeared, whereas tumor size (>5 cm), tumor number (≥2), vascular infiltration, blood transfusion, and IPC remained significant.

Conclusions

IPC is an independent risk factor for the early recurrence of HCC after surgery.

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Title: Impact of intermittent portal clamping on the early recurrence of hepatocellular carcinoma after surgery
Authors: Shenghua Hao
Shaofei Chen
Xiangwu Yang
Chidan Wan
Publication date: 01-11-2016
Publisher: Springer Japan
Published in: Surgery Today / Issue 11/2016
Print ISSN: 0941-1291
Electronic ISSN: 1436-2813
DOI: https://doi.org/10.1007/s00595-016-1316-6

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Impact of intermittent portal clamping on the early recurrence of hepatocellular carcinoma after surgery

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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