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BMC Musculoskeletal Disorders
Published in: BMC Musculoskeletal Disorders 1/2022

Open Access 01-12-2022 | Research

Impact of heterotopic ossification following lumbar total disk replacement: a systematic review

Authors: Colleen Hood, Reza Zamani, Mohammad Akrami

Published in: BMC Musculoskeletal Disorders | Issue 1/2022

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Abstract

Background context

Lumbar total disc replacement (TDR) is an alternative to lumbar fusion in the treatment of lower back pain and reduces the risk of adjacent segment degeneration. Heterotopic ossification (HO) has been identified as a common complication following lumbar TDR.

Purpose

This systematic review aims to determine the prevalence, risk factors and clinical and radiological impact of HO following lumbar TDR.

Study Design

Systematic Review.

Methods

MEDLINE, Scopus, PubMed and Cochrane Central were searched for articles that referred to lumbar TDR and HO. The hits were assessed against inclusion and exclusion criteria. Data from each included study was extracted and analysed with respect to the study aims.

Results

Twenty-six studies were included in this review and the pooled prevalence of HO was estimated to be between 13.2% (participants) and 15.3% (vertebral levels). TDR clinical outcomes were not found to be reduced by HO and there was insufficient data to identify a given impact upon radiological outcomes. Age and follow up time were identified as potential risk factors for HO.

Conclusions

This review was hampered by inconsistencies in the reporting of HO across the studies. We therefore recommend that a set of guidelines should be produced to aid future researchers and reduce the risk of bias.
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Metadata
Title
Impact of heterotopic ossification following lumbar total disk replacement: a systematic review
Authors
Colleen Hood
Reza Zamani
Mohammad Akrami
Publication date
01-12-2022
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2022
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/s12891-022-05322-9

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