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Social Psychiatry and Psychiatric Epidemiology

Published in:

01-03-2012 | Original Paper

Impact of fetal versus perinatal hypoxia on sex differences in childhood outcomes: developmental timing matters

Authors: Michael Anastario, Carolyn M. Salafia, Garrett Fitzmaurice, Jill M. Goldstein

Published in: Social Psychiatry and Psychiatric Epidemiology | Issue 3/2012

Abstract

Purpose

To examine how the timing of hypoxic exposure results in specific childhood outcomes and whether there is a differential effect by sex.

Methods

A sample of 10,879 prospectively followed pregnancies was drawn from the Boston and Providence sites (New England, NE) of the National Collaborative Perinatal Project. Based on placental pathology, we developed and validated a measure of probable chronic placental hypoxia (CHP) and contrasted the effects of acute perinatal hypoxia on age 7 emotional, behavioral, and cognitive outcomes.

Results

Perinatal hypoxia had a significant impact on multiple behavioral and cognitive outcomes in boys and girls by age 7, in contrast to probable CHP which had a differential effect on girls and boys such that there was decreased verbal IQ and increased inhibition in females alone.

Conclusions

Findings underscore the importance of considering the timing of obstetric complications and offspring sex in investigations of the impact of fetal and perinatal hypoxia on offspring’s outcomes throughout the life course.

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Title: Impact of fetal versus perinatal hypoxia on sex differences in childhood outcomes: developmental timing matters
Authors: Michael Anastario
Carolyn M. Salafia
Garrett Fitzmaurice
Jill M. Goldstein
Publication date: 01-03-2012
Publisher: Springer-Verlag
Published in: Social Psychiatry and Psychiatric Epidemiology / Issue 3/2012
Print ISSN: 0933-7954
Electronic ISSN: 1433-9285
DOI: https://doi.org/10.1007/s00127-011-0353-0

At a glance: The STEP trials

Springer Medicine

Impact of fetal versus perinatal hypoxia on sex differences in childhood outcomes: developmental timing matters

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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