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Reproductive Biology and Endocrinology
Published in: Reproductive Biology and Endocrinology 1/2009

Open Access 01-12-2009 | Research

Impact of female age and male infertility on ovarian reserve markers to predict outcome of assisted reproduction technology cycles

Authors: Tsung-Hsien Lee, Chung-Hsien Liu, Chun-Chia Huang, Kung-Chen Hsieh, Pi-Mei Lin, Maw-Sheng Lee

Published in: Reproductive Biology and Endocrinology | Issue 1/2009

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Abstract

Background

This study was designed to assess the capability of ovarian reserve markers, including baseline FSH levels, baseline anti-Müllerian hormone (AMH) levels, and antral follicle count (AFC), as predictors of live births during IVF cycles, especially for infertile couples with advanced maternal age and/or male factors.

Methods

A prospective cohort of 336 first IVF/ICSI cycles undergoing a long protocol with GnRH agonist was investigated. Patients with endocrine disorders or unilateral ovaries were excluded.

Results

Among the ovarian reserve tests, AMH and age had a greater area under the receiving operating characteristic curve than FSH in predicting live births. Furthermore, AMH and age were the sole predictive factors of live births for women greater than or equal to 35 years of age; while AMH was the major determinant of live births for infertile couples with absence of male factors by multivariate logistic regression analysis. However, all the studied ovarain reserve tests were not preditive of live births for women < 35 years of age or infertile couples with male factors.

Conclusion

The serum AMH levels were prognostic for pregnancy outcome for infertile couples with advanced female age or absence of male factors. The predictive capability of ovarian reserve tests is clearly influenced by the etiology of infertility.
Appendix
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Metadata
Title
Impact of female age and male infertility on ovarian reserve markers to predict outcome of assisted reproduction technology cycles
Authors
Tsung-Hsien Lee
Chung-Hsien Liu
Chun-Chia Huang
Kung-Chen Hsieh
Pi-Mei Lin
Maw-Sheng Lee
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Reproductive Biology and Endocrinology / Issue 1/2009
Electronic ISSN: 1477-7827
DOI
https://doi.org/10.1186/1477-7827-7-100

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