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BMC Psychiatry

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Open Access 01-12-2018 | Research article

Impact of childhood trauma on sensory gating in patients with first-episode schizophrenia

Authors: Xian-Bin Li, Qi-Jing Bo, Qing Tian, Ning-Bo Yang, Zhen Mao, Wei Zheng, Yu-Jie Wen, Chuan-Yue Wang

Published in: BMC Psychiatry | Issue 1/2018

Abstract

Background

Childhood trauma (CT) has been found to contribute to the onset of schizophrenia and auditory sensory gating deficit is a leading endophenotype for schizophrenia. However, the association between the CT and sensory gating in first-episode schizophrenia remains elusive.

Methods

Fifty-six patients and 49 age and sex-matched healthy controls were assessed using the Childhood Trauma Questionnaire-Short Form (CTQ-SF) for CT and Positive and Negative Syndrome Scale (PANSS) for symptoms severity. Sensory gating was tested using the modified paradigm, perceived spatial separation-induced prepulse inhibition (PSS-PPI), and the perceived spatial co-location PPI (PSC-PPI or classical PPI).

Results

Comparing with healthy controls, the patients had significantly higher score on sexual abuse (t = 2.729, p < 0.05), lower PSS- PPI, % (ISI = 120 ms and ISI = 60 ms) (t = − 3.089, − 4.196, p < 0.05). Univariate analysis revealed the absence of a significant correlation among CT, PPI paradigms and symptoms. However, multiple linear regression analyses demonstrated the CTQ-SF total was negatively associated with PSS PPI (ISI = 120 ms) (p = 0.018).

Conclusion

The current study illustrates that the impact of CT on sensory gating in patients with first-episode schizophrenia, and thus we conclude that CT may be a risk factor to the occurrence of schizophrenia through its impact on sensory gating.

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Title: Impact of childhood trauma on sensory gating in patients with first-episode schizophrenia
Authors: Xian-Bin Li
Qi-Jing Bo
Qing Tian
Ning-Bo Yang
Zhen Mao
Wei Zheng
Yu-Jie Wen
Chuan-Yue Wang
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: BMC Psychiatry / Issue 1/2018
Electronic ISSN: 1471-244X
DOI: https://doi.org/10.1186/s12888-018-1807-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Impact of childhood trauma on sensory gating in patients with first-episode schizophrenia

Abstract

Background

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusion

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