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01-10-2009 | Brief report

Impact of a mixed strength and endurance exercise intervention on levels of adiponectin, high molecular weight adiponectin and leptin in breast cancer survivors

Authors: Jennifer A. Ligibel, Anita Giobbie-Hurder, Deanna Olenczuk, Nancy Campbell, Taylor Salinardi, Eric P. Winer, Christos S. Mantzoros

Published in: Cancer Causes & Control | Issue 8/2009

Abstract

Evidence suggests that exercise affects breast cancer risk and outcomes, but little is known about the mechanisms through which this effect may be mediated. This study examines the impact of exercise upon levels of adiponectin, high molecular weight adiponectin (HMWA), and leptin in breast cancer survivors.

Methods

One hundred and one sedentary, overweight breast cancer survivors were randomized to a 16-week exercise intervention or usual care control group. Anthropometric measurements were taken and fasting levels of adiponectin, HMWA and leptin were collected at baseline and 16 weeks.

Results

Baseline and week-16 measurements were available for 81 patients. The exercise group experienced a significant decrease in hip measurements, with no change in weight or body composition. There were no significant changes in adiponectin, HMWA, or leptin in either group. Modeling analyses demonstrated a significant inverse relationship between changes in leptin and adiponectin, but no relationship between changes in BMI, waist or hip circumference, or body fat percentage and change in leptin or adiponectin.

Conclusions

This study did not demonstrate a significant change in adipocytokine levels in breast cancer survivors participating in an exercise intervention, suggesting that further work is needed to explore the mechanisms through which exercise may impact breast cancer.

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Title: Impact of a mixed strength and endurance exercise intervention on levels of adiponectin, high molecular weight adiponectin and leptin in breast cancer survivors
Authors: Jennifer A. Ligibel
Anita Giobbie-Hurder
Deanna Olenczuk
Nancy Campbell
Taylor Salinardi
Eric P. Winer
Christos S. Mantzoros
Publication date: 01-10-2009
Publisher: Springer Netherlands
Published in: Cancer Causes & Control / Issue 8/2009
Print ISSN: 0957-5243
Electronic ISSN: 1573-7225
DOI: https://doi.org/10.1007/s10552-009-9358-3

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