Top

Published in:

01-04-2021 | Brief Report

Impact of 970 nm photobiomodulation therapy on wound healing in cellular models of hidradenitis suppurativa

Authors: Luisa Zupin, Giulia Ferri, Paola Maura Tricarico, Rossella Gratton, Cécile Nait-Meddour, Giulia Ottaviani, Sergio Crovella

Published in: Lasers in Medical Science | Issue 3/2021

Excerpt

Hidradenitis Suppurativa (HS, OMIM#142690) is a chronic, severe inflammatory skin disease [1]. It is characterized by the presence of double-ended comedones, subcutaneous nodules, sinus tracts, fibrotic scars, and dermal contractures in the apocrine gland-bearing body areas such as axillae, inguinal, perianal, and inframammary regions [1]. HS impacts negatively on patient’ quality of life; in fact, it presents chronic recurrent manifestations, extremely painful and debilitating for the individuals; moreover, the discharge of purulent materials from the lesions leads to feeling of embarrassment and social isolation [2]. …

Jemec GBE (2012) Hidradenitis Suppurativa. N Engl J Med 366:158–164. https://doi.org/10.1056/NEJMcp1014163CrossRefPubMed

Koumaki D, Efthymiou O, Bozi E, Katoulis AC (2019) Perspectives on perceived stigma and self-stigma in patients with hidradenitis suppurativa. Clin Cosmet Investig Dermatol 12:785–790. https://doi.org/10.2147/CCID.S180036CrossRefPubMedPubMedCentral

Karimkhani C, Boyers LN, Margolis DJ et al (2014) Comparing cutaneous research funded by the National Institute of Arthritis and Musculoskeletal and Skin Diseases with 2010 global burden of disease results. PLoS One 9:e102122. https://doi.org/10.1371/journal.pone.0102122CrossRefPubMedPubMedCentral

Scheinfeld N (2013) Treatment of hidradenitis supprurativa associated pain with nonsteroidal anti-inflammatory drugs, acetaminophen, celecoxib, gabapentin, pegabalin, duloxetine, and venlafaxine. Dermatol Online J 19:20616PubMed

Saunte DM, Boer J, Stratigos A et al (2015) Diagnostic delay in hidradenitis suppurativa is a global problem. Br J Dermatol 173:1546–1549. https://doi.org/10.1111/bjd.14038CrossRefPubMed

Gasparic J, Theut Riis P, Jemec GB (2017) Recognizing syndromic hidradenitis suppurativa: a review of the literature. J Eur Acad Dermatol Venereol 31:1809–1816. https://doi.org/10.1111/jdv.14464CrossRefPubMed

Tricarico PM, Boniotto M, Genovese G et al (2019) An integrated approach to unravel hidradenitis suppurativa etiopathogenesis. Front Immunol:10. https://doi.org/10.3389/fimmu.2019.00892

Jfri AH, O’Brien EA, Litvinov IV et al (2019) Hidradenitis suppurativa: comprehensive review of predisposing genetic mutations and changes. J Cutan Med Surg 23:519–527. https://doi.org/10.1177/1203475419852049CrossRefPubMed

Wang B, Yang W, Wen W et al (2010) γ-Secretase gene mutations in familial acne Inversa. Science 330:1065–1065. https://doi.org/10.1126/science.1196284CrossRefPubMed

10.

Zouboulis CC, Bechara FG, Dickinson-Blok JL et al (2019) Hidradenitis suppurativa/acne inversa: a practical framework for treatment optimization - systematic review and recommendations from the HS ALLIANCE working group. J Eur Acad Dermatol Venereol 33:19–31. https://doi.org/10.1111/jdv.15233CrossRefPubMed

11.

Gulliver W, Zouboulis CC, Prens E et al (2016) Evidence-based approach to the treatment of hidradenitis suppurativa/acne inversa, based on the European guidelines for hidradenitis suppurativa. Rev Endocr Metab Disord 17:343–351. https://doi.org/10.1007/s11154-016-9328-5CrossRefPubMedPubMedCentral

12.

Jemec G, Guérin A, Okun M et al (2013) Economic burden of hidradenitis suppurativa after a single surgical intervention: assessment of unmet needs using a retrospective claims-based analysis. J Am Acad Dermatol 68:AB48. https://doi.org/10.1016/j.jaad.2012.12.203CrossRef

13.

Hamzavi IH, Griffith JL, Riyaz F et al (2015) Laser and light-based treatment options for hidradenitis suppurativa. J Am Acad Dermatol 73:S78–S81. https://doi.org/10.1016/j.jaad.2015.07.050CrossRefPubMed

14.

Highton L, Chan W-Y, Khwaja N, Laitung JKG (2011) Treatment of hidradenitis suppurativa with intense pulsed light: a prospective study. Plast Reconstr Surg 128:459–466. https://doi.org/10.1097/PRS.0b013e31821e6fb5CrossRefPubMed

15.

Saunte DM, Lapins J (2016) Lasers and intense pulsed light hidradenitis suppurativa. Dermatol Clin 34:111–119. https://doi.org/10.1016/j.det.2015.08.001CrossRefPubMed

16.

Jourabchi N, Anzaldi L, Erdag G, Cohen B (2018) Pulsed-dye laser treatment of a nonhealing chronic wound that developed after incision and drainage of a hidradenitis suppurativa abscess. Dermatol Surg 44:447–449. https://doi.org/10.1097/DSS.0000000000001224CrossRefPubMed

17.

Robert E, Bodin F, Paul C et al (2017) Non-surgical treatments for hidradenitis suppurativa: a systematic review. Ann Chir Plast Esthet 62:274–294. https://doi.org/10.1016/j.anplas.2017.03.012CrossRefPubMed

18.

Tsai S-R, Hamblin MR (2017) Biological effects and medical applications of infrared radiation. J Photochem Photobiol B Biol 170:197–207. https://doi.org/10.1016/j.jphotobiol.2017.04.014CrossRef

19.

Tricarico PM, Zupin L, Ottaviani G et al (2018) Photobiomodulation therapy promotes in vitro wound healing in nicastrin KO HaCaT cells. J Biophotonics 11:e201800174. https://doi.org/10.1002/jbio.201800174CrossRefPubMed

20.

Ferri G, Tricarico PM, Vincelli I et al (2019) Photobiomodulation therapy is able to decrease IL1B gene expression in an in vitro cellular model of hidradenitis suppurativa. Lasers Med Sci. https://doi.org/10.1007/s10103-019-02868-4

21.

Zupin L, Ottaviani G, Rupel K et al (2019) Analgesic effect of Photobiomodulation therapy: an in vitro and in vivo study. J Biophotonics 12. https://doi.org/10.1002/jbio.201900043

22.

Takeo M, Lee W, Ito M (2015) Wound healing and skin regeneration. Cold Spring Harbor Perspect Med 5:a023267–a023267. https://doi.org/10.1101/cshperspect.a023267CrossRef

23.

Rupel K, Zupin L, Colliva A et al (2018) Photobiomodulation at multiple wavelengths differentially modulates oxidative stress in vitro and in vivo. Oxidative Med Cell Longev 2018:1–11. https://doi.org/10.1155/2018/6510159CrossRef

24.

Ottaviani G, Martinelli V, Rupel K et al (2016) Laser therapy inhibits tumor growth in mice by promoting immune surveillance and vessel normalization. EBioMedicine 11:165–172. https://doi.org/10.1016/j.ebiom.2016.07.028CrossRefPubMedPubMedCentral

25.

Chermetz M, Gobbo M, Ronfani L et al (2014) Class IV laser therapy as treatment for chemotherapy-induced oral mucositis in onco-haematological paediatric patients: a prospective study. Int J Paediatr Dent 24:441–449. https://doi.org/10.1111/ipd.12090CrossRefPubMed

26.

Gobbo M, Ottaviani G, Perinetti G et al (2014) Evaluation of nutritional status in head and neck radio-treated patients affected by oral mucositis: efficacy of class IV laser therapy. Support Care Cancer 22:1851–1856. https://doi.org/10.1007/s00520-014-2155-xCrossRefPubMed

27.

Gobbo M, Ottaviani G, Mustacchi G et al (2012) Acneiform rash due to epidermal growth factor receptor inhibitors: high-level laser therapy as an innovative approach. Lasers Med Sci 27:1085–1090. https://doi.org/10.1007/s10103-011-1029-4CrossRefPubMed

28.

Wilson VG (2013) Growth and differentiation of HaCaT keratinocytes. In: Turksen K (ed) Epidermal Cells. Springer New York, New York, pp 33–41CrossRef

29.

Sanjana NE, Shalem O, Zhang F (2014) Improved vectors and genome-wide libraries for CRISPR screening. Nat Methods 11:783–784. https://doi.org/10.1038/nmeth.3047CrossRefPubMedPubMedCentral

30.

Fox LT, Mazumder A, Dwivedi A et al (2017) In vitro wound healing and cytotoxic activity of the gel and whole-leaf materials from selected aloe species. J Ethnopharmacol 200:1–7. https://doi.org/10.1016/j.jep.2017.02.017CrossRefPubMed

31.

R core Team (2019) R: a Language and Environment for Statistical Computing

32.

Burney RE (2017) 35-year experience with surgical treatment of hidradenitis suppurativa. World J Surg 41:2723–2730. https://doi.org/10.1007/s00268-017-4091-7CrossRefPubMed

33.

Pastar I, Stojadinovic O, Yin NC et al (2014) Epithelialization in wound healing: a comprehensive review. Adv Wound Care (New Rochelle) 3:445–464. https://doi.org/10.1089/wound.2013.0473CrossRef

34.

Li A, Peng Y, Taiclet LM, Tanzi RE (2019) Analysis of hidradenitis suppurativa–linked mutations in four genes and the effects of PSEN1-P242LfsX11 on cytokine and chemokine expression in macrophages. Hum Mol Genet 28:1173–1182. https://doi.org/10.1093/hmg/ddy414CrossRefPubMed

35.

Ottaviani G, Gobbo M, Sturnega M et al (2013) Effect of class IV laser therapy on chemotherapy-induced oral mucositis: a clinical and experimental study. Am J Pathol 183:1747–1757. https://doi.org/10.1016/j.ajpath.2013.09.003CrossRefPubMed

36.

Zein R, Selting W, Hamblin MR (2018) Review of light parameters and photobiomodulation efficacy: dive into complexity. J Biomed Opt 23:1. https://doi.org/10.1117/1.JBO.23.12.120901CrossRefPubMed

37.

de Abreu PTR, de Arruda JAA, Mesquita RA et al (2019) Photobiomodulation effects on keratinocytes cultured in vitro: a critical review. Lasers Med Sci 34:1725–1734. https://doi.org/10.1007/s10103-019-02813-5CrossRefPubMed

Title: Impact of 970 nm photobiomodulation therapy on wound healing in cellular models of hidradenitis suppurativa
Authors: Luisa Zupin
Giulia Ferri
Paola Maura Tricarico
Rossella Gratton
Cécile Nait-Meddour
Giulia Ottaviani
Sergio Crovella
Publication date: 01-04-2021
Publisher: Springer London
Published in: Lasers in Medical Science / Issue 3/2021
Print ISSN: 0268-8921
Electronic ISSN: 1435-604X
DOI: https://doi.org/10.1007/s10103-020-03097-w

At a glance: The STEP trials

Springer Medicine

Impact of 970 nm photobiomodulation therapy on wound healing in cellular models of hidradenitis suppurativa

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Issue 3/2021

Isotretinoin plus 420 nm intense pulsed light versus isotretinoin alone for the treatment of acne vulgaris: a randomized, controlled study of efficacy, safety, and patient satisfaction in Chinese subjects

Effects of photobiomodulation on cellular viability and cancer stem cell phenotype in oral squamous cell carcinoma

Laser and LED photobiomodulation effects in osteogenic or regular medium on rat calvaria osteoblasts obtained by newly forming bone technique

Effect of photobiomodulation on CCC-ESF reactive oxygen species steady-state in high glucose mediums

Non-excisional laser therapies for hemorrhoidal disease: a systematic review of the literature

Evaluating the efficacy and safety of vascular IPL for treatment of acute cutaneous leishmaniasis: a randomized controlled trial