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Archives of Dermatological Research
Published in: Archives of Dermatological Research 1/2018

01-01-2018 | Concise Communication

Immunohistochemical distribution of Ki67 in epidermis of thick glabrous skin of human digits

Authors: Aleksandar Petrovic, Vladimir Petrovic, Bobana Milojkovic, Ivan Nikolic, Dragan Jovanovic, Aleksandra Antovic, Miroslav Milic

Published in: Archives of Dermatological Research | Issue 1/2018

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Abstract

The glabrous skin on the flexor sides of hands and feet, compared to other integument regions, has thicker epidermis and more complex pattern of epidermal ridges, wherefore in microscopy is denominated as thick skin. The epidermis of this skin type has individually unique and permanent superficial patterns, called dermatoglyphics, which are maintained by regenerative potential of deep epidermal rete ridges, that interdigitate with adjacent dermis. Using light microscopy, we analyzed cadaveric big toes thick skin samples, described histology of deep epidermal ridges (intermediate, limiting, and transverse), and quantitatively evidenced their pattern of proliferation by immunohistochemical assessment of Ki67. Immunohistochemical distribution of Ki67 was confined to basal and suprabasal layers, with pattern of distribution specific for intermediate, limiting and transverse ridges that gradually transform within epidermal height. Deep epidermal ridges, interdigitating with dermal papillae, participate in construction of intricate epidermal base, whose possible role in epidermal regeneration was also discussed. Having a prominent morphology, this type of epidermis offers the best morphological insight in complexities of skin organization, and its understanding could challenge and improve currently accepted models of epidermal organization.
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Metadata
Title
Immunohistochemical distribution of Ki67 in epidermis of thick glabrous skin of human digits
Authors
Aleksandar Petrovic
Vladimir Petrovic
Bobana Milojkovic
Ivan Nikolic
Dragan Jovanovic
Aleksandra Antovic
Miroslav Milic
Publication date
01-01-2018
Publisher
Springer Berlin Heidelberg
Published in
Archives of Dermatological Research / Issue 1/2018
Print ISSN: 0340-3696
Electronic ISSN: 1432-069X
DOI
https://doi.org/10.1007/s00403-017-1793-5

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