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Head & Neck Oncology
Published in: Head & Neck Oncology 1/2010

Open Access 01-12-2010 | Research

Immunohistochemical analysis of undifferentiated and poorly-differentiated head and neck malignancies at a tertiary hospital in Nigeria

Authors: Akinyele O Adisa, Abideen O Oluwasola, Bukola F Adeyemi, Bamidele Kolude, Effiong EU Akang, Jonathan O Lawoyin

Published in: Head & Neck Oncology | Issue 1/2010

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Absract

This is a retrospective analysis of poorly-differentiated head and neck malignancies at University College Hospital, Ibadan.
Eighty-six poorly-differentiated neoplasms were categorized as carcinomas, sarcomas, lymphomas or neuroendocrine cancers with a panel of 7 antibodies (cytokeratin AE1/AE3, vimentin, desmin, myogenin, leukocyte common antigen and neuron-specific enolase). Immunohistochemical and original hematoxylin-eosin diagnoses were contrasted.
The male: female ratio was 2.5:1, with mean age of 38.9 years. Nasopharynx, nose and maxillofacial bones were the most common locations. Immunohistochemistry confirmed 54.8% of carcinomas, 70.6% of sarcomas and 80% of lymphomas.
Hematoxylin-eosin was able to distinguish between sarcoma and lymphoma but differentiation between a carcinoma and neuroendocrine lesion was poor. Further studies are required to maximize the role of immunohistochemistry as an ancillary diagnostic tool in the West African sub-region.
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Metadata
Title
Immunohistochemical analysis of undifferentiated and poorly-differentiated head and neck malignancies at a tertiary hospital in Nigeria
Authors
Akinyele O Adisa
Abideen O Oluwasola
Bukola F Adeyemi
Bamidele Kolude
Effiong EU Akang
Jonathan O Lawoyin
Publication date
01-12-2010
Publisher
BioMed Central
Published in
Head & Neck Oncology / Issue 1/2010
Electronic ISSN: 1758-3284
DOI
https://doi.org/10.1186/1758-3284-2-33

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