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01-11-2018 | What's New in Intensive Care

Immunoglobulins and sepsis

Authors: Manu Shankar-Hari, Martin Bruun Madsen, Alexis F. Turgeon

Published in: Intensive Care Medicine | Issue 11/2018

Excerpt

Intravenous immunoglobulins are considered as potential adjuvant therapy in sepsis patients. We present a narrative review of recent research into the associations between immunoglobulins and sepsis. …

Shankar-Hari M, Spencer J, Sewell WA, Rowan KM, Singer M (2012) Bench-to-bedside review: immunoglobulin therapy for sepsis—biological plausibility from a critical care perspective. Crit Care 16:206CrossRef

Shankar-Hari M, Culshaw N, Post B, Tamayo E, Andaluz-Ojeda D, Bermejo-Martin JF, Dietz S, Werdan K, Beale R, Spencer J, Singer M (2015) Endogenous IgG hypogammaglobulinaemia in critically ill adults with sepsis: systematic review and meta-analysis. Intensive Care Med 41:1393–1401CrossRef

Shankar-Hari M, Singer M, Spencer J (2017) Can Concurrent abnormalities in free light chains and immunoglobulin concentrations identify a target population for immunoglobulin trials in sepsis? Crit Care Med 45:1829–1836CrossRef

Bermejo-Martin JF, Rodriguez-Fernandez A, Herran-Monge R, Andaluz-Ojeda D, Muriel-Bombin A, Merino P, Garcia-Garcia MM, Citores R, Gandia F, Almansa R, Blanco J, Group G (2014) Immunoglobulins IgG1, IgM and IgA: a synergistic team influencing survival in sepsis. J Intern Med 276:404–412CrossRef

Martin-Loeches I, Muriel-Bombin A, Ferrer R, Artigas A, Sole-Violan J, Lorente L, Andaluz-Ojeda D, Prina-Mello A, Herran-Monge R, Suberviola B, Rodriguez-Fernandez A, Merino P, Loza AM, Garcia-Olivares P, Anton E, Tamayo E, Trapiello W, Blanco J, Bermejo-Martin JF, group G (2017) The protective association of endogenous immunoglobulins against sepsis mortality is restricted to patients with moderate organ failure. Ann Intensive Care 7:44CrossRef

Giamarellos-Bourboulis EJ, Apostolidou E, Lada M, Perdios I, Gatselis NK, Tsangaris I, Georgitsi M, Bristianou M, Kanni T, Sereti K, Kyprianou MA, Kotanidou A, Armaganidis A, Hellenic Sepsis Study Group (2013) Kinetics of circulating immunoglobulin M in sepsis: relationship with final outcome. Crit Care 17:R247CrossRef

Nakano T, Matsui M, Inoue I, Awata T, Katayama S, Murakoshi T (2011) Free immunoglobulin light chain: its biology and implications in diseases. Clin Chim Acta 412:843–849CrossRef

Shankar-Hari M, Fear D, Lavender P, Mare T, Beale R, Swanson C, Singer M, Spencer J (2017) Activation-associated accelerated apoptosis of memory B cells in critically ill patients with sepsis. Crit Care Med 45:875–882CrossRef

Soares MO, Welton NJ, Harrison DA, Peura P, Shankar- Hari M, Harvey SE, Madan JJ, Ades AE, Palmer SJ, Rowan KM (2012) An evaluation of the feasibility, cost and value of information of a multicentre randomised controlled trial of intravenous immunoglobulin for sepsis (severe sepsis and septic shock): incorporating a systematic review, meta-analysis and value of information analysis. Health Technol Assess 16:1–186CrossRef

10.

Turgeon AF, Hutton B, Fergusson DA, McIntyre L, Tinmouth AA, Cameron DW, Hebert PC (2007) Meta-analysis: intravenous immunoglobulin in critically ill adult patients with sepsis. Ann Intern Med 146:193–203CrossRef

11.

Shankar-Hari M, Harrison DA, Rowan KM (2016) Differences in impact of definitional elements on mortality precludes international comparisons of sepsis epidemiology-a cohort study illustrating the need for standardized reporting. Crit Care Med 44:2223–2230CrossRef

12.

Burnham KL, Davenport EE, Radhakrishnan J, Humburg P, Gordon AC, Hutton P, Svoren-Jabalera E, Garrard C, Hill AVS, Hinds CJ, Knight JC (2017) Shared and distinct aspects of the sepsis transcriptomic response to fecal peritonitis and pneumonia. Am J Respir Crit Care Med 196:328–339CrossRef

13.

Shankar-Hari M, Rubenfeld GD (2017) The use of enrichment to reduce statistically indeterminate or negative trials in critical care. Anaesthesia 72:560–565CrossRef

14.

Giamarellos-Bourboulis EJ, Tziolos N, Routsi C, Katsenos C, Tsangaris I, Pneumatikos I, Vlachogiannis G, Theodorou V, Prekates A, Antypa E, Koulouras V, Kapravelos N, Gogos C, Antoniadou E, Mandragos K, Armaganidis A, Hellenic Sepsis Study Group (2016) Improving outcomes of severe infections by multidrug-resistant pathogens with polyclonal IgM-enriched immunoglobulins. Clin Microbiol Infect 22:499–506CrossRef

15.

Ishikura H, Nakamura Y, Kawano Y, Tanaka J, Mizunuma M, Ohta D, Nishida T, Murai A (2015) Intravenous immunoglobulin improves sepsis-induced coagulopathy: a retrospective, single-center observational study. J Crit Care 30:579–583CrossRef

Title: Immunoglobulins and sepsis
Authors: Manu Shankar-Hari
Martin Bruun Madsen
Alexis F. Turgeon
Publication date: 01-11-2018
Publisher: Springer Berlin Heidelberg
Published in: Intensive Care Medicine / Issue 11/2018
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-018-5047-6

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Immunoglobulins and sepsis

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