Top

Published in:

01-08-2017 | Case Report

Immunoglobulin-responsive chikungunya encephalitis: two case reports

Authors: Stephanie Suzanne de O. Scott, Pedro Braga-Neto, Lícia Pacheco Pereira, Paulo Ribeiro Nóbrega, Francisco de Assis Aquino Gondim, Manoel Alves Sobreira-Neto, Claudia Carvalho Mendes Schiavon

Published in: Journal of NeuroVirology | Issue 4/2017

Abstract

Chikungunya virus is an alphavirus transmitted by the mosquito Aedes, mainly Aedes aegypti and Aedes albopictus, that can cause acute illness, mostly self-limited, characterized by fever, maculopapular rash, and disabling polyarthritis/arthralgia, with an incubation period of 1 to 12 days. Chikungunya was largely regarded as a non-fatal and self-limited disease, but recently, serious cases have been reported including some with severe involvement of the nervous system, such as meningoencephalitis, myelitis, polyradiculitis, and polyradiculoneuropathy. In this report, we describe the clinical and laboratory findings of two patients with encephalitis associated with chikungunya in a northeastern city in Brazil, who exhibited a good outcome, with improvement after treatment with i.v. immunoglobulin (IVIg).

Azevedo RSS, Oliveira CS, Vasconcelos PFC (2015) Risco do Chikungunya para o Brasil. Rev Saude Publica 49

Courderc T, Lecuit M (2015) Chikungunya virus pathogenesis: from bedside to bench. Antivir Res 121:120–131CrossRef

Crosby L, Perreau C, Madeux B, Cossis J, Armand C, Herrmann-Storke C, Najioullah F, Valentino R, Thiéry G (2016) Severe manifestations of chikungunya virus in critically ill patients during the 2013–2014 Caribbean outbreak. Intern J Infect Dis v 48:78–80CrossRef

Das T, Jaffar-Bandjee M, Hoarau J, Trotot P, Denizot M, Lee-Pat-Yuen G, Sahoo R, Guiraud P, Ramful D, Robin S, Alessandri J, Gauzere B, Gasque P (2010) Chikungunya fever: CNS infection and pathologies of a re-emerging arbovirus. Prog Neurobiol 91:121–129CrossRefPubMed

Das T, Horarau MC, Bandjee J, Gasque MMP (2015) Multifaceted immune responses engaged by astrocytes, microglia and resident dendritic cells against chikungunya neuroinfection. J Gen Virol 96:294–310CrossRefPubMed

Donalisio MR, Freitas AR (2015) Chikungunya in Brasil: an emerging challenge. Rev Bras Epidemiol 18(1)

Ganesan K, Diwan A, Shankar SK, Desai SB, Saiani GS, Katrak SM (2008) Chikungunya encephalomyeloradiculitis: report of 2 cases with neuroimaging and 1 case with autopsy findings. AJNR 29

Gérardin P, Couderc T, Bintner M, Tournebize P, Renouil M, Lémant J, Boisson V, Borguerini G, Staikowsky F, Schramm F, Lecuit M, Michault A (2015) Chikungunya virus-associated encephalitis. Neurology 86

Hjalmarsson A, Blomqvist P, Skoldenberg B (2007) Herpes simplex encephalitis in Sweden, 1990–2001: incidence, morbidity, and mortality. Clin Infect Dis 45(7):875–880CrossRefPubMed

Labadie K, Larcher T, Joubert C, Mannioui A, Delache B, Brochard P et al (2010) Chikungunya disease in nonhuman primates involves long term viral persistence in macrophages. J Clin Invest 120:894–906CrossRefPubMedPubMedCentral

Mohan A, Kiran DHN, Manohar IC, Kumar DP (2010) Epidemiology, clinical manifestations and diagnosis of chikungunya fever: lessons learned from the re-emerging epidemic. Indian J Dermatol 55(1):54–63CrossRefPubMedPubMedCentral

Nelson J, Waggoner J, Sahoo M, Grant P, Pinsky B (2014) Encephalitis caused by chikungunya virus in a traveler from the Kingdom of Tonga. J Clin Microbiol 52(9):3459–3461CrossRefPubMedPubMedCentral

Sansoni P, Vescovini R, Fagnoni F, Biasini C, Zanni F, Zanlari L, Telera A, Lucchini C, Passeri G, Monti D, Franceschi C, Passeri M (2008) The immune system in extreme longevity. Exp Gerontol 43(2):61–65CrossRefPubMed

Ziegler SA, Lu L, da Rosa AP, Xiao SY, Tesh RB (2008) An animal model for studying the pathogenesis of chikungunya virus infection. AmJTrop Med Hyg 79:133–139

Title: Immunoglobulin-responsive chikungunya encephalitis: two case reports
Authors: Stephanie Suzanne de O. Scott
Pedro Braga-Neto
Lícia Pacheco Pereira
Paulo Ribeiro Nóbrega
Francisco de Assis Aquino Gondim
Manoel Alves Sobreira-Neto
Claudia Carvalho Mendes Schiavon
Publication date: 01-08-2017
Publisher: Springer International Publishing
Published in: Journal of NeuroVirology / Issue 4/2017
Print ISSN: 1355-0284
Electronic ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-017-0535-y

At a glance: The STEP trials

Springer Medicine

Immunoglobulin-responsive chikungunya encephalitis: two case reports

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 4/2017

Robust gene expression changes in the ganglia following subclinical reactivation in rhesus macaques infected with simian varicella virus

Modeling brain lentiviral infections during antiretroviral therapy in AIDS

White matter measures are near normal in controlled HIV infection except in those with cognitive impairment and longer HIV duration

Response to the letter to the editor by Andreas Sauerbrei on “Acyclovir resistance in herpes simplex type I encephalitis, a case report”

The EGF epidermal growth factor counteracts Tat modulation of human endogenous retroviruses of the W family in astrocytes

The nature and consequences of cognitive deficits among tobacco smokers with HIV: a comparison to tobacco smokers without HIV