Top

Published in:

01-12-2009 | Original Article

IL-18 105 A>C polymorphism contributes to renal manifestations in patients with SLE

Authors: Teresa Warchoł, Margarita Lianeri, Mariusz Wudarski, Jan K. Łącki, Paweł Piotr Jagodziński

Published in: Rheumatology International | Issue 2/2009

Abstract

Systemic lupus erythematosus (SLE) is a multisystem autoimmune connective tissue disorder characterized by various aberrations including increased production of IL-18. As IL-18 105 A>C polymorphic variants have been linked to increased production of this cytokine, we investigated the prevalence of IL-18 105 A>C (rs549908) polymorphic variants in SLE patients (n = 111) and controls (n = 152). There were no significant differences in the distribution of IL-18 105 A>C polymorphic variants in SLE patients and controls. However, there was a significant association between the IL-18 105 AA genotype (recessive model) and renal manifestations OR = 3.360 (1.523–7.415, P = 0.0039) and the P value remained statistically significant after Bonferroni correction (P _corr = 0.0351).Our findings indicate that the IL-18 105 AA genotype variant can contribute to renal manifestations in patients with SLE.

Sekigawa I, Naito T, Hira K, Mitsuishi K, Ogasawara H, Hashimoto H, Ogawa H (2004) Possible mechanisms of gender bias in SLE: a new hypothesis involving a comparison of SLE with atopy. Lupus 13:217–222. doi:10.1191/0961203304lu1012ed CrossRefPubMed

Bombardier C, Gladman DD, Urowitz MB, Caron D, Chang CH (1992) Derivation of the SLEDAI A disease activity index for lupus patients. The Committee on Prognosis Studies in SLE. Arthritis Rheum 35:630–640. doi:10.1002/art.1780350606 CrossRefPubMed

Tsokos GC, Liossis SN (1999) Immune cell signaling defects in lupus: activation, anergy and death. Immunol Today 20:119–124. doi:10.1016/S0167-5699(98)01395-4 CrossRefPubMed

Januchowski R, Wudarski M, Chwalińska-Sadowska H, Jagodzinski PP (2008) Prevalence of ZAP-70, LAT, SLP-76, and DNA methyltransferase 1 expression in CD4(+) T cells of patients with systemic lupus erythematosus. Clin Rheumatol 27:21–27. doi:10.1007/s10067-007-0644-8 CrossRefPubMed

Stohl W, Metyas S, Tan SM, Cheema GS, Oamar B, Xu D, Roschke V, Wu Y, Baker KP, Hilbert DM (2003) B lymphocyte stimulator overexpression in patients with systemic lupus erythematosus: longitudinal observations. Arthritis Rheum 48:3475–3486. doi:10.1002/art.11354 CrossRefPubMed

Gröndal G, Gunnarsson I, Rönnelid J, Rogberg S, Klareskog L, Lundberg I (2000) Cytokine production, serum levels and disease activity in systemic lupus erythematosus. Clin Exp Rheumatol 18:565–570PubMed

al-Janadi M, al-Balla S, al-Dalaan A, Raziuddin S (1993) Cytokine profile in systemic lupus erythematosus, rheumatoid arthritis, and other rheumatic diseases. J Clin Immunol 13:58–67. doi:10.1007/BF00920636 CrossRefPubMed

Nakanishi K, Yoshimoto T, Tsutsui H, Okamura H (2001) Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu. Cytokine Growth Factor Rev 12:53–72. doi:10.1016/S1359-6101(00)00015-0 CrossRefPubMed

Dinarello CA (1999) Interleukin-18. Methods 19:121–132. doi:10.1006/meth.1999.0837 CrossRefPubMed

10.

Rothe H, Jenkins NA, Copeland NG, Kolb H (1997) Active stage of autoimmune diabetes is associated with the expression of a novel cytokine, IGIF, which is located near Idd2. J Clin Invest 99:469–474. doi:10.1172/JCI119181 CrossRefPubMed

11.

Gracie JA, Forsey RJ, Chan WL, Gilmour A, Leung BP, Greer MR, Kennedy K, Carter R, Wei XQ, Xu D, Field M, Foulis A, Liew FY, McInnes IB (1999) A proinflammatory role for IL-18 in rheumatoid arthritis. J Clin Invest 104:1393–1401. doi:10.1172/JCI7317 CrossRefPubMed

12.

Monteleone G, Trapasso F, Parrello T, Biancone L, Stella A, Iuliano R, Luzza F, Fusco A, Pallone F (1999) Bioactive IL-18 expression is up-regulated in Crohn’s disease. J Immunol 163:143–147PubMed

13.

Yamano T, Higashi T, Nouso K, Nakatsukasa H, Kariyama K, Yumoto E, Kobayashi Y, Yamamoto K, Iwagaki H, Yagi T, Tanimoto T, Kurimoto M, Tanaka N, Tsuji T (2000) Serum interferon-gamma-inducing factor/IL-18 levels in primary biliary cirrhosis. Clin Exp Immunol 122:227–231. doi:10.1046/j.1365-2249.2000.01356.x CrossRefPubMed

14.

Wozniacka A, Lesiak A, Narbutt J, McCauliffe DP, Sysa-Jedrzejowska A (2006) Chloroquine treatment influences proinflammatory cytokine levels in systemic lupus erythematosus patients. Lupus 15:268–275. doi:10.1191/0961203306lu2299oa CrossRefPubMed

15.

Panafidina TA, Popkova TV, Alekberova ZS, Mach ES, Aleksandrova EN, Nasonov EL (2008) Interleukin-18 in systemic lupus erythematosus: link with clinical symptoms and vascular atherosclerosis. Ter Arkh 80:41–46PubMed

16.

Ogata A, Kitano M, Fukamizu M, Hamano T, Sano H (2004) Increased serum interleukin-18 in a patient with systemic lupus erythematosus and T-cell large granular lymphocytic leukemia. Mod Rheumatol 14:267–270. doi:10.1007/s10165-004-0306-5 CrossRefPubMed

17.

Wong M, Tsao BP (2006) Current topics in human SLE genetics. Springer Semin Immunopathol 28:97–107. doi:10.1007/s00281-006-0031-6 CrossRefPubMed

18.

Harley JB, Kelly JA, Kaufman KM (2006) Unraveling the genetics of systemic lupus erythematosus. Springer Semin Immunopathol 28:119–130. doi:10.1007/s00281-006-0040-5 CrossRefPubMed

19.

Imanishi T, Morinobu A, Hayashi N, Kanagawa S, Koshiba M, Kondo S, Kumagai S (2005) A novel polymorphism of the SSA1 gene is associated with anti-SS-A/Ro52 autoantibody in Japanese patients with primary Sjögren’s syndrome. Clin Exp Rheumatol 23:521–524PubMed

20.

Al-Awadhi AM, Haider MZ, Sharma PN, Hasan EA, Botaiban F, Al-Herz A, Nahar I, Al-Enezi H, Al-Saeid K (2007) Angiotensin-converting enzyme gene polymorphism in Kuwaiti patients with systemic lupus erythematosus. Clin Exp Rheumatol 25:437–442PubMed

21.

Burzynski M, Duriagin S, Mostowska M, Wudarski M, Chwalinska-Sadowska H, Jagodzinski PP (2007) MTR 2756 A > G polymorphism is associated with the risk of systemic lupus erythematosus in the Polish population. Lupus 16:450–454. doi:10.1177/0961203307077988 CrossRefPubMed

22.

Giedraitis V, He B, Huang WX, Hillert J (2001) Cloning and mutation analysis of the human IL-18 promoter: a possible role of polymorphisms in expression regulation. J Neuroimmunol 112:146–152. doi:10.1016/S0165-5728(00)00407-0 CrossRefPubMed

23.

Bushley AW, Ferrell R, McDuffie K, Terada KY, Carney ME, Thompson PJ, Wilkens LR, Tung KH, Ness RB, Goodman MT (2004) Polymorphisms of interleukin (IL)-1α, IL-1β, IL-6, IL-10, and IL-18 and the risk of ovarian cancer. Gynecol Oncol 95:672–679. doi:10.1016/j.ygyno.2004.08.024 CrossRefPubMed

24.

Pratesi C, Bortolin MT, Bidoli E, Tedeschi R, Vaccher E, Dolcetti R, Guidoboni M, Franchin G, Barzan L, Zanussi S, Caruso C, De Paoli P (2006) Interleukin-10 and interleukin-18 promoter polymorphisms in an Italian cohort of patients with undifferentiated carcinoma of nasopharyngeal type. Cancer Immunol Immunother 55:23–30. doi:10.1007/s00262-005-0688-z CrossRefPubMed

25.

Imboden M, Nieters A, Bircher AJ, Brutsche M, Becker N, Wjst M, Ackermann-Liebrich U, Berger W, Probst-Hensch NM, SAPALDIA Team (2006) Cytokine gene polymorphisms and atopic disease in two European cohorts (ECRHS-Basel and SAPALDIA). Clin Mol Allergy 4:1–9. doi:10.1186/1476-7961-4-9 CrossRef

26.

Zhang PA, Wu JM, Li Y, Yang XS (2005) Association of polymorphisms of interleukin-18 gene promoter region with chronic hepatitis B in Chinese Han population. World J Gastroenterol 11:1594–1598PubMed

27.

Nieters A, Linseisen J, Becker N (2004) Association of polymorphisms in Th1, Th2 cytokine genes with hayfever and atopy in a subsample of EPIC-Heidelberg. Clin Exp Allergy 34:346–353. doi:10.1111/j.1365-2222.2004.01889.x CrossRefPubMed

28.

Shin HD, Kim LH, Park BL, Choi YH, Park HS, Hong SJ, Choi BW, Lee JH, Park CS (2005) Association of interleukin 18 (IL18) polymorphisms with specific IgE levels to mite allergens among asthmatic patients. Allergy 60:900–906. doi:10.1111/j.1398-9995.2005.00619.x CrossRefPubMed

29.

Kruse S, Kuehr J, Moseler M, Kopp MV, Kurz T, Deichmann KA, Foster PS, Mattes J (2003) Polymorphisms in the IL 18 gene are associated with specific sensitization to common allergens and allergic rhinitis. J Allergy Clin Immunol 111:117–122. doi:10.1067/mai.2003.43 CrossRefPubMed

30.

Pawlik A, Kurzawski M, Czerny B, Gawronska-Szklarz B, Drozdzik M, Herczynska M (2006) Interleukin-18 promoter polymorphism in patients with rheumatoid arthritis. Tissue Antigens 67:415–418. doi:10.1111/j.1399-0039.2006.00582.x CrossRefPubMed

31.

Lee CC, Lin WY, Wan L, Tsai Y, Lin YJ, Tsai CH, Huang CM, Tsai FJ (2007) Interleukin-18 gene polymorphism, but not interleukin-2 gene polymorphism, is associated with rheumatoid arthritis. Immunogenetics 59:433–439. doi:10.1007/s00251-007-0212-z CrossRefPubMed

32.

Lin YJ, Wan L, Sheu JJ, Huang CM, Lin CW, Lan YC, Lai CH, Hung CH, Tsai Y, Tsai CH, Lin TH, Chen CP, Tsai FJ (2008) A/C polymorphism in the interleukin-18 coding region among Taiwanese systemic lupus erythematosus patients. Lupus 17:124–127. doi:10.1177/0961203307086031 CrossRefPubMed

33.

Higa S, Hirano T, Mayumi M, Hiraoka M, Ohshima Y, Nambu M, Yamaguchi E, Hizawa N, Kondo N, Matsui E, Katada Y, Miyatake A, Kawase I, Tanaka T (2003) Association between interleukin-18 gene polymorphism 105 A/C and asthma. Clin Exp Allergy 33:1097–1102. doi:10.1046/j.1365-2222.2003.01739.x CrossRefPubMed

34.

Arimitsu J, Hirano T, Higa S, Kawai M, Naka T, Ogata A, Shima Y, Fujimoto M, Yamadori T, Hagiwara K, Ohgawara T, Kuwabara Y, Kawase I, Tanaka T (2006) IL-18 gene polymorphisms affect IL-18 production capability by monocytes. Biochem Biophys Res Commun 342:1413–1416. doi:10.1016/j.bbrc.2006.02.096 CrossRefPubMed

35.

Tan EM, Cohen AS, Fries JF, Masi AT, McShane DJ, Rothfield NF, Schaller JG, Talal N, Winchester RJ (1982) The 1982 revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 25:1271–1277. doi:10.1002/art.1780251101 CrossRefPubMed

36.

Hochberg MC (1997) Updating the American College of Rheumatology revised criteria for the classification of systemic lupus erythematosus. Arthritis Rheum 40:1725. doi:10.1002/art.1780400928 CrossRefPubMed

37.

Lin YJ, Wan L, Lee CC, Huang CM, Tsai Y, Tsai CH, Shin TL, Chao K, Liu CM, Xiao JW, Tsai FJ (2007) Disease association of the interleukin-18 promoter polymorphisms in Taiwan Chinese systemic lupus erythematosus patients. Genes Immun 8:302–307. doi:10.1038/sj.gene.6364387 CrossRefPubMed

38.

Xu Q, Tin SK, Sivalingam SP, Thumboo J, Koh DR, Fong KY (2007) Interleukin-18 promoter gene polymorphisms in Chinese patients with systemic lupus erythematosus: association with CC genotype at position-607. Ann Acad Med Singapore 36:91–95PubMed

39.

Lan Y, Wei YS, Tang XS, Qin J, Wu J, Qin JM (2008) Association of interleukin-18 gene polymorphism with genetic susceptibility to systematic lupus erythematosus in Guangxi Zhuang population. Zhonghua Yi Xue Yi Chuan Xue Za Zhi 25:434–437PubMed

40.

Pavlovna KO, Sergeevna SN, Anatolievna LJ, Ivanovich KJ, Leonidovich FM, Alexandrovich KE, L’vovich GE, Vladimirovna YE, Alexandrovich KV, Vitalievich SS (2008) Association of single nucleotide polymorphisms in the IL-18 gene with production of IL-18 protein by mononuclear cells from healthy donors. Mediators Inflamm 2008:309721

41.

Tucci M, Quatraro C, Lombardi L, Pellegrino C, Dammacco F, Silvestris F (2008) Glomerular accumulation of plasmacytoid dendritic cells in active lupus nephritis: role of interleukin-18. Arthritis Rheum 58:251–262. doi:10.1002/art.23186 CrossRefPubMed

42.

Wong CK, Ho CY, Li EK, Tam LS, Lam CW (2002) Elevated production of interleukin-18 is associated with renal disease in patients with systemic lupus erythematosus. Clin Exp Immunol 130:345–351. doi:10.1046/j.1365-2249.2002.01989.x CrossRefPubMed

43.

Faust J, Menke J, Kriegsmann J, Kelley VR, Mayet WJ, Galle PR, Schwarting A (2002) Correlation of renal tubular epithelial cell-derived interleukin-18 up-regulation with disease activity in MRL-Faslpr mice with autoimmune lupus nephritis. Arthritis Rheum 46:3083–3095. doi:10.1002/art.10563 CrossRefPubMed

44.

Love LA (1994) New environmental agents associated with lupus-like disorders. Lupus 3:467–471. doi:10.1177/096120339400300607 CrossRefPubMed

Title: IL-18 105 A>C polymorphism contributes to renal manifestations in patients with SLE
Authors: Teresa Warchoł
Margarita Lianeri
Mariusz Wudarski
Jan K. Łącki
Paweł Piotr Jagodziński
Publication date: 01-12-2009
Publisher: Springer-Verlag
Published in: Rheumatology International / Issue 2/2009
Print ISSN: 0172-8172
Electronic ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-009-0934-3

Live Webinar | 27-06-2024 | 18:00 (CEST)

Keynote webinar | Spotlight on medication adherence

Reserve your place

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

WHO estimates that half of all patients worldwide are non-adherent to their prescribed medication. The consequences of poor adherence can be catastrophic, on both the individual and population level.

Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.

Prof. Kevin Dolgin

Prof. Florian Limbourg

Prof. Anoop Chauhan

Developed by: Springer Medicine

Obesity Clinical Trial Summary

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 2/2009

Thrombocytopenia as a presenting feature of Kawasaki disease: a case series from North India

In-office magnetic resonance imaging to monitor responses to therapy in rheumatoid arthritis

Effect of aerobic exercise training on oxygen uptake and kinetics in patients with fibromyalgia

Improvement of functional ability in children with juvenile idiopathic arthritis by treatment with etanercept

Disease burden of psoriatic arthritis compared to rheumatoid arthritis, Hungarian experiment

Association of anti-CCP positivity with serum ferritin and DAS-28

Keynote webinar | Spotlight on medication adherence

Live: Thursday 27th June 2024, 18:00-19:30 (CEST)

At a glance: The STEP trials