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20-07-2022 | Editorial

If you don’t kill pollution it could kill you: pathophysiologic insights into pollution mediated cardiovascular risk through FDG PET imaging

Authors: Kartik Gupta, MD, Karthik Ananthasubramaniam, MD, FACC, FASE, FASNC, FSCCT, FSCMR, FRCP

Published in: Journal of Nuclear Cardiology | Issue 2/2023

Excerpt

Air pollution (AP) ranks fourth after hypertension, dietary risk factors, and dyslipidemia as the most important modifiable risk factor for cardiovascular (CV) diseases.¹ Highest impact of AP is seen in low- and middle-income countries in Asia, the Middle East, and Africa which have a relatively younger population, and high rates of premature CV death; the global impact of AP is also significant.¹ There is a dose-response relationship between short-term exposure to particulate ambient AP and increased CV death.² The relative risk is logically higher with long-term exposure.³ …

Roth GA, Mensah GA, Johnson CO, Addolorato G, Ammirati E, Baddour LM. Global burden of cardiovascular diseases and risk factors, 1990–2019: Update from the GBD 2019 study. J Am Coll Cardiol 2020;76:2982‐3021.CrossRefPubMedPubMedCentral

Liu C, Chen R, Sera F, Vicedo-Cabrera AM, Guo Y, Tong S, et al. Ambient particulate air pollution and daily mortality in 652 cities. N Engl J Med 2019;381:705‐15.CrossRefPubMedPubMedCentral

Pope CA, Burnett RT, Thurston GD, Thun MJ, Calle EE, Krewski D, et al. Cardiovascular mortality and long-term exposure to particulate air pollution. Circulation 2004;109:71‐7.CrossRefPubMed

Willerson JT, Ridker PM. Inflammation as a cardiovascular risk factor. Circulation 2004;109:2‐10.

Brook RD, Franklin B, Cascio W, Hong Y, Howard G, Lipsett M, et al. Air pollution and cardiovascular disease: A statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association. Circulation 2004;109:2655‐71.CrossRefPubMed

Chan YL, Wang B, Chen H, Ho KF, Cao J, Hai G, et al. Pulmonary inflammation induced by low-dose particulate matter exposure in mice. Am J Physiol Lung Cell Mol Physiol 2019;317:L424‐30.CrossRefPubMedPubMedCentral

Rajagopalan S, Landrigan PJ. Pollution and the heart. N Engl J Med 2021;385:1881‐92.CrossRefPubMed

Münzel T, Gori T, Babisch W, Basner M. Cardiovascular effects of environmental noise exposure. Eur Heart J 2014;35:829‐36.CrossRefPubMedPubMedCentral

Münzel T, Steven S, Hahad O, Daiber A. The sixth sense is involved in noise-induced stress responses and vascular inflammation: Evidence for heightened amygdalar activity in response to transport noise in man. Eur Heart J 2019;41:783‐5.CrossRef

10.

Osborne MT, Radfar A, Hassan MZO, Abohashem S, Oberfeld B, Patrich T, et al. A neurobiological mechanism linking transportation noise to cardiovascular disease in humans. Eur Heart J 2019;41:772‐82.CrossRefPubMedCentral

11.

Brook RD, Rajagopalan S, Pope CA III, Brook JR, Bhatnagar A, Diez-Roux AV, et al. Particulate matter air pollution and cardiovascular disease: An update to the scientific statement from the American Heart Association. Circulation 2010;121:2331‐78.CrossRefPubMed

12.

Emami H, Singh P, MacNabb M, Vucic E, Lavender Z, Rudd JH, et al. Splenic metabolic activity predicts risk of future cardiovascular events: Demonstration of a cardiosplenic axis in humans. JACC Cardiovasc Imaging 2015;8:121‐30.CrossRefPubMedPubMedCentral

13.

Figueroa AL, Abdelbaky A, Truong QA, Corsini E, MacNabb MH, Lavender ZR, et al. Measurement of arterial activity on routine FDG PET/CT images improves prediction of risk of future CV events. JACC Cardiovasc Imaging 2013;6:1250‐9.CrossRefPubMed

14.

Poller WC, Nahrendorf M, Swirski FK. Hematopoiesis and cardiovascular disease. Circ Res 2020;126:1061‐85.CrossRefPubMedPubMedCentral

15.

Abohashem S, Osborne MT, Dar T, Naddaf N, Abbasi T, Ghoneem A, et al. A leucopoietic-arterial axis underlying the link between ambient air pollution and cardiovascular disease in humans. Eur Heart J 2021;42:761‐72.CrossRefPubMedPubMedCentral

16.

Tétreault LF, Perron S, Smargiassi A. Cardiovascular health, traffic-related air pollution and noise: Are associations mutually confounded? A systematic review. Int J Public Health 2013;58:649‐66.CrossRefPubMed

17.

Robertson S, Miller MR. Ambient air pollution and thrombosis. Part Fibre Toxicol 2018;15:1.CrossRefPubMedPubMedCentral

18.

Pekkanen J, Brunner EJ, Anderson HR, Tiittanen P, Atkinson RW. Daily concentrations of air pollution and plasma fibrinogen in London. Occup Environ Med 2000;57:818‐22.CrossRefPubMedPubMedCentral

19.

Zhang S, Breitner S, Cascio WE, Devlin RB, Neas LM, Ward-Caviness C, et al. Association between short-term exposure to ambient fine particulate matter and myocardial injury in the CATHGEN cohort. Environ Pollut 2021;275:116663.CrossRefPubMed

20.

Brook RD, Rajagopalan S. Getting sympathetic about air pollution exposure. J Am Heart Assoc 2021;10:e021675.CrossRefPubMedPubMedCentral

21.

Rankin GD, Kabéle M, Brown R, Macefield VG, Sandström T, Bosson JA. Acute exposure to diesel exhaust increases muscle sympathetic nerve activity in humans. J Am Heart Assoc 2021;10:e018448.CrossRefPubMedPubMedCentral

22.

Chossière GP, Xu H, Dixit Y, Isaacs S, Eastham SD, Allroggen F, et al. Air pollution impacts of COVID-19-related containment measures. Sci Adv 2021. https://doi.org/10.1126/sciadv.abe1178.CrossRefPubMedPubMedCentral

23.

Giani P, Castruccio S, Anav A, Howard D, Hu W, Crippa P. Short-term and long-term health impacts of air pollution reductions from COVID-19 lockdowns in China and Europe: A modelling study. Lancet Planet Health 2020;4:e474‐82.CrossRefPubMedPubMedCentral

Title: If you don’t kill pollution it could kill you: pathophysiologic insights into pollution mediated cardiovascular risk through FDG PET imaging
Authors: Kartik Gupta, MD
Karthik Ananthasubramaniam, MD, FACC, FASE, FASNC, FSCCT, FSCMR, FRCP
Publication date: 20-07-2022
Publisher: Springer International Publishing
Published in: Journal of Nuclear Cardiology / Issue 2/2023
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-022-03022-4

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If you don’t kill pollution it could kill you: pathophysiologic insights into pollution mediated cardiovascular risk through FDG PET imaging

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