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Published in: BMC Musculoskeletal Disorders 1/2018

Open Access 01-12-2018 | Research article

Identifying individuals with chronic pain after knee replacement: a population-cohort, cluster-analysis of Oxford knee scores in 128,145 patients from the English National Health Service

Authors: Rafael Pinedo-Villanueva, Sara Khalid, Vikki Wylde, Rachael Gooberman-Hill, Anushka Soni, Andrew Judge

Published in: BMC Musculoskeletal Disorders | Issue 1/2018

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Abstract

Background

Approximately one in five patients undergoing knee replacement surgery experience chronic pain after their operation, which can negatively impact on their quality of life. In order to develop and evaluate interventions to improve the management of chronic post-surgical pain, we aimed to derive a cut-off point in the Oxford Knee Score pain subscale to identify patients with chronic pain following knee replacement, and to characterise these patients using self-reported outcomes.

Methods

Data from the English Patient-Reported Outcome Measures (PROMs) programme were used. This comprised patient-reported data from 128,145 patients who underwent primary knee replacement surgery in England between 2012 and 2015. Cluster analysis was applied to derive a cut-off point on the pain subscale of the Oxford Knee Score.

Results

A high-pain group was identified, described by a maximum of 14 points in the Oxford Knee Score pain subscale six months after surgery. The high-pain group, comprising 15% of the sample, was characterised by severe and frequent problems in all pain dimensions, particularly in pain severity, night pain and limping, as well as in all dimensions of health-related quality of life.

Conclusions

Patients with Oxford Knee Score pain subscale scores of 14 or less at six months after knee replacement can be considered to be in chronic pain that is likely to negatively affect their quality of life. This derived cut-off can be used for patient selection in research settings to design and assess interventions that support patients in their management of chronic post-surgical pain.
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Literature
1.
go back to reference Cross M, Smith E, Hoy D, Nolte S, Ackerman I, Fransen M, Bridgett L, Williams S, Guillemin F, Hill CL: The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis 2014:annrheumdis-2013-204763. Cross M, Smith E, Hoy D, Nolte S, Ackerman I, Fransen M, Bridgett L, Williams S, Guillemin F, Hill CL: The global burden of hip and knee osteoarthritis: estimates from the global burden of disease 2010 study. Ann Rheum Dis 2014:annrheumdis-2013-204763.
2.
go back to reference Beswick AD, Wylde V, Gooberman-Hill R, Blom A, Dieppe P. What proportion of patients report long-term pain after total hip or knee replacement for osteoarthritis? A systematic review of prospective studies in unselected patients. BMJ Open. 2012;2(1):e000435.CrossRef Beswick AD, Wylde V, Gooberman-Hill R, Blom A, Dieppe P. What proportion of patients report long-term pain after total hip or knee replacement for osteoarthritis? A systematic review of prospective studies in unselected patients. BMJ Open. 2012;2(1):e000435.CrossRef
3.
go back to reference Kurtz S, Ong K, Lau E, Mowat F, Halpern M. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. JBJS. 2007;89(4):780–5. Kurtz S, Ong K, Lau E, Mowat F, Halpern M. Projections of primary and revision hip and knee arthroplasty in the United States from 2005 to 2030. JBJS. 2007;89(4):780–5.
4.
go back to reference National Joint Registry for England W, Northern Ireland and the Isle or Man,: 14th Annual Report 2017. In.; 2017. National Joint Registry for England W, Northern Ireland and the Isle or Man,: 14th Annual Report 2017. In.; 2017.
5.
go back to reference Jeffery AE, Wylde V, Blom AW, Horwood JP. "It's there and I'm stuck with it": patients' experiences of chronic pain following total knee replacement surgery. Arthritis Care Res (Hoboken). 2011;63(2):286–92.CrossRef Jeffery AE, Wylde V, Blom AW, Horwood JP. "It's there and I'm stuck with it": patients' experiences of chronic pain following total knee replacement surgery. Arthritis Care Res (Hoboken). 2011;63(2):286–92.CrossRef
6.
go back to reference Smith TO, Dainty JR, MacGregor AJ. Changes in social isolation and loneliness following total hip and knee arthroplasty: longitudinal analysis of the English longitudinal study of ageing (ELSA) cohort. Osteoarthritis Cartilage. 25(9):1414–9.CrossRef Smith TO, Dainty JR, MacGregor AJ. Changes in social isolation and loneliness following total hip and knee arthroplasty: longitudinal analysis of the English longitudinal study of ageing (ELSA) cohort. Osteoarthritis Cartilage. 25(9):1414–9.CrossRef
7.
go back to reference Jinks C, Ong BN, Richardson J. A mixed methods study to investigate needs assessment for knee pain and disability: population and individual perspectives. BMC Musculoskelet Disord. 2007;8(1):59.CrossRef Jinks C, Ong BN, Richardson J. A mixed methods study to investigate needs assessment for knee pain and disability: population and individual perspectives. BMC Musculoskelet Disord. 2007;8(1):59.CrossRef
8.
go back to reference Boonstra AM, Schiphorst Preuper HR, Balk GA, Stewart RE. Cut-off points for mild, moderate, and severe pain on the visual analogue scale for pain in patients with chronic musculoskeletal pain. Pain. 2014;155(12):2545–50.CrossRef Boonstra AM, Schiphorst Preuper HR, Balk GA, Stewart RE. Cut-off points for mild, moderate, and severe pain on the visual analogue scale for pain in patients with chronic musculoskeletal pain. Pain. 2014;155(12):2545–50.CrossRef
10.
go back to reference Dawson J, Fitzpatrick R, Murray D, Carr A. Questionnaire on the perceptions of patients about total knee replacement. J Bone Joint Surg Br. 1998;80-B(1):63–9.CrossRef Dawson J, Fitzpatrick R, Murray D, Carr A. Questionnaire on the perceptions of patients about total knee replacement. J Bone Joint Surg Br. 1998;80-B(1):63–9.CrossRef
11.
go back to reference The EuroQol Group. EuroQol - a new facility for the measurement of health-related quality of life. Health Policy. 1990;16(3):199–208.CrossRef The EuroQol Group. EuroQol - a new facility for the measurement of health-related quality of life. Health Policy. 1990;16(3):199–208.CrossRef
12.
13.
go back to reference Werner MU, Kongsgaard UE. I. Defining persistent post-surgical pain: is an update required? Br J Anaesth. 2014;113(1):1–4.CrossRef Werner MU, Kongsgaard UE. I. Defining persistent post-surgical pain: is an update required? Br J Anaesth. 2014;113(1):1–4.CrossRef
14.
go back to reference Lenguerrand E, Wylde V, Gooberman-Hill R, Sayers A, Brunton L, Beswick AD, Dieppe P, Blom AW. Trajectories of pain and function after primary hip and knee arthroplasty: the ADAPT cohort study. PLoS One. 2016;11(2).CrossRef Lenguerrand E, Wylde V, Gooberman-Hill R, Sayers A, Brunton L, Beswick AD, Dieppe P, Blom AW. Trajectories of pain and function after primary hip and knee arthroplasty: the ADAPT cohort study. PLoS One. 2016;11(2).CrossRef
15.
go back to reference Halket A, Stratford PW, Kennedy DM, Woodhouse LJ. Using hierarchical linear modeling to explore predictors of pain after Total hip and knee arthroplasty as a consequence of osteoarthritis. J Arthroplast. 2010;25(2):254–62.CrossRef Halket A, Stratford PW, Kennedy DM, Woodhouse LJ. Using hierarchical linear modeling to explore predictors of pain after Total hip and knee arthroplasty as a consequence of osteoarthritis. J Arthroplast. 2010;25(2):254–62.CrossRef
16.
go back to reference Scott CEH, Howie CR, MacDonald D, Biant LC. Predicting dissatisfaction following total knee replacement: a prospective study of 1217 patients. J Bone Joint Surg. 2010;92-B(9):1253–8.CrossRef Scott CEH, Howie CR, MacDonald D, Biant LC. Predicting dissatisfaction following total knee replacement: a prospective study of 1217 patients. J Bone Joint Surg. 2010;92-B(9):1253–8.CrossRef
17.
go back to reference Harris K, Dawson J, Doll H, Field RE, Murray DW, Fitzpatrick R, Jenkinson C, Price AJ, Beard DJ. Can pain and function be distinguished in the Oxford knee score in a meaningful way? An exploratory and confirmatory factor analysis. Qual Life Res. 2013;22(9):2561–8.CrossRef Harris K, Dawson J, Doll H, Field RE, Murray DW, Fitzpatrick R, Jenkinson C, Price AJ, Beard DJ. Can pain and function be distinguished in the Oxford knee score in a meaningful way? An exploratory and confirmatory factor analysis. Qual Life Res. 2013;22(9):2561–8.CrossRef
18.
go back to reference Cruz-Almeida Y, King CD, Goodin BR, Sibille KT, Glover TL, Riley JL, Sotolongo A, Herbert MS, Schmidt J, Fessler BJ. Psychological profiles and pain characteristics of older adults with knee osteoarthritis. Arthritis Care Res. 2013;65(11):1786–94.CrossRef Cruz-Almeida Y, King CD, Goodin BR, Sibille KT, Glover TL, Riley JL, Sotolongo A, Herbert MS, Schmidt J, Fessler BJ. Psychological profiles and pain characteristics of older adults with knee osteoarthritis. Arthritis Care Res. 2013;65(11):1786–94.CrossRef
19.
go back to reference Murphy SL, Lyden AK, Phillips K, Clauw DJ, Williams DA. Subgroups of older adults with osteoarthritis based upon differing comorbid symptom presentations and potential underlying pain mechanisms. Arthritis Res Ther. 2011;13(4):R135.CrossRef Murphy SL, Lyden AK, Phillips K, Clauw DJ, Williams DA. Subgroups of older adults with osteoarthritis based upon differing comorbid symptom presentations and potential underlying pain mechanisms. Arthritis Res Ther. 2011;13(4):R135.CrossRef
20.
go back to reference Egsgaard LL, Eskehave TN, Bay-Jensen AC, Hoeck HC, Arendt-Nielsen L. Identifying specific profiles in patients with different degrees of painful knee osteoarthritis based on serological biochemical and mechanistic pain biomarkers: a diagnostic approach based on cluster analysis. Pain. 2015;156(1):96–107.CrossRef Egsgaard LL, Eskehave TN, Bay-Jensen AC, Hoeck HC, Arendt-Nielsen L. Identifying specific profiles in patients with different degrees of painful knee osteoarthritis based on serological biochemical and mechanistic pain biomarkers: a diagnostic approach based on cluster analysis. Pain. 2015;156(1):96–107.CrossRef
21.
go back to reference Frey-Law LA, Bohr NL, Sluka KA, Herr K, Clark CR, Noiseux NO, Callaghan JJ, Zimmerman MB, Rakel BA. Pain sensitivity profiles in patients with advanced knee osteoarthritis. Pain. 2016;157(9):1988–99.CrossRef Frey-Law LA, Bohr NL, Sluka KA, Herr K, Clark CR, Noiseux NO, Callaghan JJ, Zimmerman MB, Rakel BA. Pain sensitivity profiles in patients with advanced knee osteoarthritis. Pain. 2016;157(9):1988–99.CrossRef
22.
go back to reference Khalid S, Judge A, Pinedo-Villanueva R. An Unsupervised Learning Model for Pattern Recognition in Routinely Collected Healthcare Data. In Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies. HEALTHINF. 2018;5:266–73. ISBN 978-989-758-281-3. https://doi.org/10.5220/0006535602660273. Khalid S, Judge A, Pinedo-Villanueva R. An Unsupervised Learning Model for Pattern Recognition in Routinely Collected Healthcare Data. In Proceedings of the 11th International Joint Conference on Biomedical Engineering Systems and Technologies. HEALTHINF. 2018;5:266–73. ISBN 978-989-758-281-3. https://​doi.​org/​10.​5220/​0006535602660273​.
23.
go back to reference Dolan P. Modeling valuations for EuroQol health states. Med Care. 1997;35(11):1095–108.CrossRef Dolan P. Modeling valuations for EuroQol health states. Med Care. 1997;35(11):1095–108.CrossRef
24.
go back to reference Judge A, Arden NK, Kiran A, Price A, Javaid MK, Beard D, Murray D, Field RE. Interpretation of patient-reported outcomes for hip and knee replacement surgery: identification of thresholds associated with satisfaction with surgery. J Bone Joint Surg Br. 2012;94-B(3):412–8.CrossRef Judge A, Arden NK, Kiran A, Price A, Javaid MK, Beard D, Murray D, Field RE. Interpretation of patient-reported outcomes for hip and knee replacement surgery: identification of thresholds associated with satisfaction with surgery. J Bone Joint Surg Br. 2012;94-B(3):412–8.CrossRef
25.
go back to reference Wylde V, Hewlett S, Learmonth ID, Dieppe P. Persistent pain after joint replacement: prevalence, sensory qualities, and postoperative determinants. Pain. 2011;152(3):566–72.CrossRef Wylde V, Hewlett S, Learmonth ID, Dieppe P. Persistent pain after joint replacement: prevalence, sensory qualities, and postoperative determinants. Pain. 2011;152(3):566–72.CrossRef
26.
go back to reference NHS Digital: Patient Reported Outcome Measures (PROMs) in England – Data Quality Note. Finalised data for April 2014 to March 2015. In.; 2016. NHS Digital: Patient Reported Outcome Measures (PROMs) in England – Data Quality Note. Finalised data for April 2014 to March 2015. In.; 2016.
Metadata
Title
Identifying individuals with chronic pain after knee replacement: a population-cohort, cluster-analysis of Oxford knee scores in 128,145 patients from the English National Health Service
Authors
Rafael Pinedo-Villanueva
Sara Khalid
Vikki Wylde
Rachael Gooberman-Hill
Anushka Soni
Andrew Judge
Publication date
01-12-2018
Publisher
BioMed Central
Published in
BMC Musculoskeletal Disorders / Issue 1/2018
Electronic ISSN: 1471-2474
DOI
https://doi.org/10.1186/s12891-018-2270-9

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