Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on medication adherence

LIVE: Thursday 27th June 2024, 18:00-19:30 (CEST)
Join our expert panel to discover why you need to understand the drivers of non-adherence in your patients, and how you can optimize medication adherence in your clinics to drastically improve patient outcomes.
ADVANCED SEARCH
Log in
Top
Reproductive Biology and Endocrinology
Published in: Reproductive Biology and Endocrinology 1/2004

Open Access 01-12-2004 | Review

Identification of sperm immunoreactive antigens for immunocontraceptive purposes: a review

Authors: Alina Domagala, Maciej Kurpisz

Published in: Reproductive Biology and Endocrinology | Issue 1/2004

Login to get access

Abstract

Antisperm antibodies (ASA) may be a reason of infertility in some individuals. They may affect pre- as well as post-fertilization stages of the reproductive process. There is ongoing progress in the identification of sperm antigens related to fertilization. The employed methods for this purpose include recombinant DNA technology and the most advanced proteomic analysis. This paper enlists the different approaches undertaken in order to identify and characterize the immunoreactive sperm antigens. We have mainly focused on those, which have been already studied in regard of their immunocontraceptive potential, although it has been impossible to include all published data concerning the topic in a single article. Few novel sperm auto- and isoantigens, discovered recently, have also been reviewed even if their role in fertilization has not been yet established.
Literature
1.
Murdoch WJ: Immunoregulation of mammalian fertility. Review. Life Sci. 1994, 55: 1871-1886. 10.1016/0024-3205(94)00519-2.CrossRefPubMed
2.
Bradley MP, Eade J, Penhale J, Bird P: Vaccines for fertility regulation of wild and domestic species. J Biotechnol. 1999, 73: 91-101. 10.1016/S0168-1656(99)00112-1.CrossRefPubMed
3.
Bernstein IL, Englander BE, Gallagher JS, Nathan P, Marcus ZH: Localized and systemic hypersensitivity reactions to human seminal fluid. Ann Intern Med. 1981, 94: 459-65.CrossRefPubMed
4.
Kurpisz M, Alexander N: Carbohydrate moieties on sperm surface – physiological relevance. Fertil Steril. 1995, 63: 158-165.PubMed
5.
Bohring C, Krause W: Immune infertility: towards a better understanding of sperm (auto)- immunity. Hum Reprod. 2003, 18: 915-924. 10.1093/humrep/deg207.CrossRefPubMed
6.
Aitken RJ, Hulme MJ, Henderson CJ, Hargreave TB, Ross A: Analysis of the surface labelling characteristics of human spermatozoa and the interaction with anti-sperm antibodies. J Reprod Fertil. 1987, 80: 473-85. 10.1530/jrf.0.0800473.CrossRefPubMed
7.
Primakoff P, Lathrop W, Bronson R: Identification of human sperm surface glycoproteins recognized by autoantisera from immune infertile men, women, and vasectomized men. Biol Reprod. 1990, 42: 929-42.CrossRefPubMed
8.
Snow K, Ball GD: Characterization of human sperm antigens and antisperm antibodies in infertile patients. Fertil Steril. 1992, 58: 1011-9.PubMed
9.
D'Cruz OJ, Haas GG, Lambert H: Heterogeneity of human sperm surface antigens identified by indirect immunoprecipitation of antisperm antibody bound to biotinylated sperm. J Immunol. 1993, 151: 1062-74.PubMed
10.
Domagała A, Kamieniczna M, Kurpisz M: Sperm antigens recognized by antisperm antibodies present in sera of infertile adults and prepubertal boys with testicular failure. Int J Androl. 2000, 23: 150-5. 10.1046/j.1365-2605.2000.00219.x.CrossRefPubMed
11.
de Beer PM, Windt ML, Bouic PJ: Analysis of human sperm membrane antigens reacting with sera from antisperm antibody positive and negative patients by western blotting. Andrologia. 1993, 25: 149-52.CrossRefPubMed
12.
Auer J, Senechal H, De Almeida M: Sperm-associated and circulating IgA and IgG classes of antibodies recognise different antigens on the human sperm plasma membrane. J Reprod Immunol. 1997, 34: 121-136. 10.1016/S0165-0378(97)00023-5.CrossRefPubMed
13.
Auer J, senechal H, Desvaux FX, lbert M, De Almeida M: Isolation and characterisation of two sperm membrane proteins recognised by sperm-associated antibodies in infertile men. Mol Reprod Dev. 2002, 57: 393-405. 10.1002/1098-2795(200012)57:4<393::AID-MRD12>3.3.CO;2-G.CrossRef
14.
His B, Yeh C, Fenichel P, Samson M, Grivaux C: Monoclonal antibody GB24 recognizes trophoblast – lymphocyte cross-reactive antigen. Am J Reprod Immunol Microbiol. 1988, 18: 21-27.
15.
Isojima S, Kameda K, Tsuji Y, Shigeta M, Ikeda Y, Koyama K: Establishment and characterization of a human hybridoma secreting monoclonal antibody with high titers of sperm-immobilizing and agglutination activities against human seminal plasma. J Reprod Immunol. 1987, 10: 67-78. 10.1016/0165-0378(87)90051-9.CrossRefPubMed
16.
Naz RK, Morte C, Garcia Framis V, Kaplan P, Martinez P: Characterization of a sperm-specific monoclonal antibody and isolation of a 95-kilodalton fertilization antigen-2 from human sperm. Biol Reprod. 1993, 49: 1236-1244.CrossRefPubMed
17.
Herr JC, Flickinger CJ, Homyk M, Klotz K, John E: Biochemical and morphological characterization of the intra-acrosomal antigen SP-10 from human sperm. Biol Reprod. 1990, 42: 181-193.CrossRefPubMed
18.
Yan YC, Wang LF, Koide SS: Properties of a monoclonal antibody interacting with human sperm. Arch Androl. 1987, 18: 245-254.CrossRefPubMed
19.
Anderson DJ, Johnson PM, Alexander NJ, Jones WR, Griffin PO: Monoclonal antibodies to human trophoblast and sperm antigens: Report of the WHO sponsored workshop, June 30 1986, Canada. J Reprod Immunol. 1987, 10: 231-257. 10.1016/0165-0378(87)90089-1.CrossRefPubMed
20.
Liang ZG, O'Hern PA, Yavetz B, Goldberg E: Human testis cDNAs identified by sera from infertile patients: a molecular biochemical approach to immunocontraceptive development. Reprod Fertil Dev. 1994, 6: 297-305.CrossRefPubMed
21.
Liu HW, Lin YC, Chao CF, Chong SY, Sun GH: GP-83 and GP-39, two glycoproteins secreted by human epididymis are conjugated to spermatozoa during maturation. Mol Hum Reprod. 2000, 6: 422-428. 10.1093/molehr/6.5.422.CrossRefPubMed
22.
Diekman AB, Goldberg E: Characterization of a human antigen with sera from infertile patients. Biol Reprod. 1994, 50: 1087-1093.CrossRefPubMed
23.
Naz RK, Alexander NJ, Isahakia M, Hamilton MD: Monoclonal antibody to human sperm membrane glycoprotein that inhibits fertilization. Science. 1984, 225: 342-344.CrossRefPubMed
24.
Zhu Z, Naz RK: Fertilization antigen-1: cDNA cloning, testis-specific expression, and immunocontraceptive effects. Proc Natl Acad Sci USA. 1997, 94: 4704-4709. 10.1073/pnas.94.9.4704.PubMedCentralCrossRefPubMed
25.
Naz RK, Zhu X: Recombinant fertilization antigen-1 causes a contraceptive effect in actively immunized mice. Biol Reprod. 1998, 59: 1095-1100.CrossRefPubMed
26.
Naz RK, Zhu X: Molecular cloning and sequencing of a cDNA encoding for human FA-1 antigen. Mol Reprod Dev. 2002, 63: 256-68. 10.1002/mrd.90010.CrossRefPubMed
27.
Menge AC, Christman G, Ohl D, Naz RK: Fertilization antigen-1 removes antisperm autoantibodies from spermatozoa of infertile men and results in increased rates of acrosome reaction. Fertil Steril. 1999, 71: 256-260. 10.1016/S0015-0282(98)00468-3.CrossRefPubMed
28.
Wei SS, Wang LF, Miao SY, Liu QY, Koide SS: Fertility studies with antisperm antibodies. Arch Androl. 1994, 32: 251-262.CrossRefPubMed
29.
Wang LF, Wei SG, Miao SY, Liu QY, Koide SS: Calpastatin gene in human testis. Biochem Mol Biol Int. 1994, 33: 245-252.PubMed
30.
Wei SG, Wang LF, Miao SY, Zong SD, Koide SS: Expression of the calpastatin gene segment during spermatogenesis in human testis: An in situ hybridization study. Arch Androl. 1995, 34: 9-12.CrossRefPubMed
31.
Koide SS, Wang L, Kamada M: Antisperm antibodies associated with infertility: properties and encoding genes of target antigens. Proc Soc Exp Biol Med. 2000, 224: 123-132. 10.1046/j.1525-1373.2000.22410.x.CrossRefPubMed
32.
Wang LF, Miao SY, Zong SD, Bai L, Koide SS: Gene encoding a mammalian epididymal protein. Biochem Mol Biol Int. 1994, 34: 1134-1136.
33.
Macalma T, Otte J, Hensler ME, Bockholt SM, Louis HA, Kaif-suske M, Grzeschik KH, von der Ahe D, Beckerle MC: Molecular characterization of human zyxin. J Biol Chem. 1996, 271: 31470-31478. 10.1074/jbc.271.49.31470.CrossRefPubMed
34.
35.
Naz RK, Zhu X: Molecular cloning and sequencing of a cDNA encoding for a human sperm antigen involved in fertilization. Mol Reprod Dev. 1997, 48: 449-457. 10.1002/(SICI)1098-2795(199712)48:4<449::AID-MRD5>3.3.CO;2-#.CrossRefPubMed
36.
Westbrook VA, Diekman AB, Klotz KL, Khole VV, von Kapp-Herr C, Golden WL, Eddy RL, Shows TB, Stoler MH, Lee CYG, Flickinger CJ, Herr JC: Spermatid-specific expression of the novel X-linked gene product SPAN-X localized to the nucleus of human spermatozoa. Biol Reprod. 2000, 63: 469-481.PubMed
37.
Naz RK, Zhu X, Kadam AL: Identification of human sperm peptide sequence involved in egg binding for immunocontraception. Biol Reprod. 2000, 62: 318-324.CrossRefPubMed
38.
Naz RK, Packianathan JLR: Antibodies to human sperm YLP12 peptide that is involved in egg binding inhibit human sperm capacitation/acrosome reaction. Arch Androl. 2000, 45: 227-232. 10.1080/01485010050194002.CrossRefPubMed
39.
Naz RK, Chauchan SC: Presence of antibodies to sperm YLP12 synthetic peptide in sera and seminapl plasma of immunoinfertile men. Mol Hum Reprod. 2001, 7: 21-26. 10.1093/molehr/7.1.21.CrossRefPubMed
40.
Naz RK, Chauchan SC: Human sperm-specific peptide vaccine that causes long-term reversible contraception. Biol Reprod. 2002, 67: 674-680.CrossRefPubMed
41.
Naz RK, Zhu X, Kadam AL: Cloning and sequencing of cDNA encoding for a novel human testis-specific contraceptive vaccinogen: role in immunocontraception. Mol Reprod Dev. 2001, 60: 116-27. 10.1002/mrd.1068.CrossRefPubMed
42.
Chauhan SC, Naz RK: Effect of antibodies to sperm-specific recombinant contraceptive vaccinogen (rCV) on murine fertilization: search for an animal model to examine its contraceptive potential. Mol reprod Dev. 2001, 60: 116-27. 10.1002/mrd.1106.CrossRef
43.
Shibahara H, Sato I, Shetty J, Naaby-Hansen S, Herr JC, Wakimoto E, Koyama K: Two-dimensional electrophoretic analysis of sperm antigens recognized by sperm immobilizing antibodies detected in infertile women. J Reprod Immuol. 2002, 53: 1-12. 10.1016/S0165-0378(01)00092-4.CrossRef
44.
Naaby-Hansen S, Flickinger CJ, Herr JC: Two-dimensional gel electrophoretic analysis of vectorially labelled surface proteins of human spermatozoa. Biol reprod. 1997, 56: 771-787.CrossRefPubMed
45.
Shetty J, Naaby-Hansen S, Shibahara H, Bronson R, Flickinger CJ, Herr JC: Human sperm proteome: immunodominant sperm surface antigens identified with sera from infertile men and women. Biol Reprod. 1999, 61: 61-69.CrossRefPubMed
46.
Hao Z, Wolkowicz MJ, Shetty J, Klotz K, Bolling L, Sen B, Westbrook VA, Coonrod S, Flickinger CJ, Herr JC: SAMP32, a testis-specific, isoantigenic sperm acrosomal membrane-associated protein. Biol Reprod. 2002, 66: 735-744.CrossRefPubMed
47.
Rao J, Herr JC, Reddi PP, Wolkowicz MJ, Bush LA, Sherman EN, Black M., Flickinger CJ: Cloning and characterization of a novel sperm-associated isoantigen (E-3) with defensin- and lectin-like motifs expressed in rat epididymis. Biol Reprod. 2003, 68: 290-301.CrossRefPubMed
48.
Bohring C, Krause E, Haberman B, Krause W: Isolation and identification of antisperm antibodies, and their possible role in immunological infertility disease. Mol Hum Reprod. 2001, 7: 113-118. 10.1093/molehr/7.2.113.CrossRefPubMed
49.
Naaby-Hansen S, Mandal A, Wolkowicz MJ, Sen B, Westbrook VA, Shetty J, Coonrod SA, Klotz KL, Kim YH, Bush LA, Flickinger CJ, Herr JC: CABYR, a novel calcium – binding tyrosine phosphorylation – regulated fibrous sheath protein involved in capacitation. Dev Biol. 2002, 242: 236-254. 10.1006/dbio.2001.0527.CrossRefPubMed
50.
Domagała A, Kurpisz M: Immunocontraceptive by using gamete antigenic targets for population control. Ipoocrate. 2001, 3: 283-291.
51.
Domagała A, Kurpisz M: CD52 antigen – a review. Med Sci Monit. 2001, 7: 325-331.PubMed
52.
Norton EJ, Diekman AB, Westbrook VA, Flickinger CK, Herr JC: RASA, a recombinant single-chain variable fragment (scFV) antibody directed against the human sperm surface: implications for the novel contraceptives. Hum Reprod. 2001, 16: 1854-1860. 10.1093/humrep/16.9.1854.CrossRefPubMed
53.
Zhu X, Naz RK: Cloning and sequencing of a cDNA encoding for a human sperm mitogen involved in fertilization. Mol Reprod Dev. 1998, 51: 176-183. 10.1002/(SICI)1098-2795(199810)51:2<176::AID-MRD7>3.3.CO;2-Z.CrossRefPubMed
Metadata
Title
Identification of sperm immunoreactive antigens for immunocontraceptive purposes: a review
Authors
Alina Domagala
Maciej Kurpisz
Publication date
01-12-2004
Publisher
BioMed Central
Published in
Reproductive Biology and Endocrinology / Issue 1/2004
Electronic ISSN: 1477-7827
DOI
https://doi.org/10.1186/1477-7827-2-11

Other articles of this Issue 1/2004

Reproductive Biology and Endocrinology 1/2004 Go to the issue

Research

Functional effects of 17alpha-hydroxyprogesterone caproate (17P) on human myometrial contractility in vitro

Review

Comparative aspects of trophoblast development and placentation

Debate

Germline stem cells in the postnatal mammalian ovary: A phenomenon of prosimian primates and mice?

Debate

ARTs in action in non-human primates: Introduction to workshop proceedings

Review

Directed differentiation of rhesus monkey ES cells into pancreatic cell phenotypes

Research

The role of transforming growth factor-beta (TGF-beta) during ovarian follicular development in sheep