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BMC Urology

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Open Access 01-12-2012 | Research article

Identification of prostaglandin receptors in human ureters

Authors: Matthias Oll, Claudia Baumann, Turang E Behbahani, Alexander von Ruecker, Stefan C Müller, Jörg Ellinger

Published in: BMC Urology | Issue 1/2012

Abstract

Background

Prostaglandins play an important role in ureteral obstruction, but the detailed expression profiles of the prostaglandin receptors (PTGER1, PTGER2, PTGER3, PTGER4, PTGFR) remain unknown in the different parts of the human ureter.

Methods

The expression pattern of PTGER1, PTGER2, PTGER3, PTGER4 and PTGFR was determined in human distal, mid and proximal ureter and renal pelvis samples using immunohistochemistry (protein levels) and quantitative real-time PCR (mRNA).

Results

PTGER1 was highly expressed in most samples irrespective of the ureteral localization; however, urothelial cells had higher levels of PTGER1 than smooth muscle cells. PTGFR was also moderately to strongly expressed in urothelial and smooth muscle cells. In comparison, PTGER2-4 expression was mostly unexpressed or weakly expressed in urothelial and smooth cells in all regions.

Conclusions

Our data indicate high levels of PTGER1 in ureters.

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The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2490/12/35/prepub

Title: Identification of prostaglandin receptors in human ureters
Authors: Matthias Oll
Claudia Baumann
Turang E Behbahani
Alexander von Ruecker
Stefan C Müller
Jörg Ellinger
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: BMC Urology / Issue 1/2012
Electronic ISSN: 1471-2490
DOI: https://doi.org/10.1186/1471-2490-12-35

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Identification of prostaglandin receptors in human ureters

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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