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Virology Journal
Published in: Virology Journal 1/2013

Open Access 01-12-2013 | Research

Identification of a new genotype of Torque Teno Mini virus

Authors: Seyed Mohammad Jazaeri Farsani, Maarten F Jebbink, Martin Deijs, Marta Canuti, Karel A van Dort, Margreet Bakker, Bart PX Grady, Maria Prins, Formijn J van Hemert, Neeltje A Kootstra, Lia van der Hoek

Published in: Virology Journal | Issue 1/2013

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Abstract

Background

Although human torque teno viruses (TTVs) were first discovered in 1997, still many associated aspects are not clarified yet. The viruses reveal a remarkable heterogeneity and it is possible that some genotypes are more pathogenic than others. The identification of all genotypes is essential to confirm previous pathogenicity data, and an unbiased search for novel viruses is needed to identify TTVs that might be related to disease.

Method

The virus discovery technique VIDISCA-454 was used to screen serum of 55 HIV-1 positive injecting drug users, from the Amsterdam Cohort Studies, in search for novel blood-blood transmittable viruses which are undetectable via normal diagnostics or panvirus-primer PCRs.

Results

A novel torque teno mini virus (TTMV) was identified in two patients and the sequence of the full genomes were determined. The virus is significantly different from the known TTMVs (< 40% amino acid identity in ORF1), yet it contains conserved characteristics that are also present in other TTMVs. The virus is chronically present in both patients, and these patients both suffered from a pneumococcal pneumonia during follow up and had extremely low B-cells counts.

Conclusion

We describe a novel TTMV which we tentatively named TTMV-13. Further research is needed to address the epidemiology and pathogenicity of this novel virus.
Appendix
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Metadata
Title
Identification of a new genotype of Torque Teno Mini virus
Authors
Seyed Mohammad Jazaeri Farsani
Maarten F Jebbink
Martin Deijs
Marta Canuti
Karel A van Dort
Margreet Bakker
Bart PX Grady
Maria Prins
Formijn J van Hemert
Neeltje A Kootstra
Lia van der Hoek
Publication date
01-12-2013
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2013
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/1743-422X-10-323

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