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Open Access 01-12-2014 | Research

Icb-1 gene polymorphism rs1467465 is associated with susceptibility to ovarian cancer

Authors: Susanne Schüler, Claus Lattrich, Maciej Skrzypczak, Tanja Fehm, Olaf Ortmann, Oliver Treeck

Published in: Journal of Ovarian Research | Issue 1/2014

Abstract

In this study, we tested the hypothesis that single nucleotide polymorphisms (SNPs) of differentiation-associated human gene icb-1 (C1orf38) may be associated with ovarian cancer susceptibility. For this purpose, we compared the genotype and allele frequencies of the SNPs rs1467465 and rs12048235 in a group of 184 ovarian cancer patients with a control group of 184 age- and gender-matched women without any malignancy. Genotype-phenotype association revealed that A allele of SNP rs1467465 was more frequent in ovarian cancer patients than in the control group (0.40 vs. 0.33, OR 1.37, 95% CI 1.013-1.853, p = 0.04). After analysis of allele positivity we observed that A-positive genotypes were more frequent in the ovarian cancer group (0.65 vs. 0.53, OR 1.63, 95% CI 1.072-2.483, p = 0.02). Furthermore, the heterozygous genotype of rs1467465 was found to be more frequent in the patients group (0.50 vs. 0.41, OR 1.63, 95% CI 1.045-2.045, p = 0.03). No significant results were obtained with regard to SNP rs1204823. Our data suggest, that SNP rs1467465 of human gene icb-1 might affect susceptibility to ovarian cancer.

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Title: Icb-1 gene polymorphism rs1467465 is associated with susceptibility to ovarian cancer
Authors: Susanne Schüler
Claus Lattrich
Maciej Skrzypczak
Tanja Fehm
Olaf Ortmann
Oliver Treeck
Publication date: 01-12-2014
Publisher: BioMed Central
Published in: Journal of Ovarian Research / Issue 1/2014
Electronic ISSN: 1757-2215
DOI: https://doi.org/10.1186/1757-2215-7-42

At a glance: The STEP trials

Springer Medicine

Icb-1 gene polymorphism rs1467465 is associated with susceptibility to ovarian cancer

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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