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European Journal of Applied Physiology

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01-08-2021 | Ibuprofen | Original Article

Ibuprofen taken before exercise blunts the IL-6 response in older adults but does not alter bone alkaline phosphatase or c-telopeptide

Authors: Sarah J. Wherry, Pamela Wolfe, Robert S. Schwartz, Wendy M. Kohrt, Catherine M. Jankowski

Published in: European Journal of Applied Physiology | Issue 8/2021

Abstract

Introduction

Non-steroidal anti-inflammatory drugs (NSAIDs) taken before exercise have been shown to impair bone formation. NSAIDs also suppress inflammatory cytokines, such as interleukin-6 (IL-6), that can have pro-resorptive effects. It is unclear how taking NSAIDs timed around exercise influences inflammatory and bone biomarkers following an acute exercise bout in older adults.

Purpose

To determine if timing of ibuprofen use relative to a single exercise bout has acute effects on serum IL-6, bone-specific alkaline phosphatase (BAP, marker of bone formation), and c-telopeptide of type I collagen (CTX, marker of bone resorption).

Methods

As part of a 36-week exercise intervention, participants aged 60 to 75 years were randomized to 3 groups: placebo before and after exercise (PP), ibuprofen before and placebo after exercise (IP), or placebo before and ibuprofen after exercise (PI). Acute responses were studied in a subset of participants (12 PP, 17 IP, 13 PI). Blood was sampled before and immediately, 30 min, and 60 min after exercise for IL-6, BAP, and CTX.

Results

The exercise-induced increase in IL-6 was blunted in response to IP when compared to PI 60-min after exercise (p < 0.001). There were no significant differences in the change in BAP or CTX between groups at any time points

Conclusion

Ibuprofen taken before exercise dampened the inflammatory response to exercise but had no effects on bone biomarkers in older adults. It may be necessary to monitor changes for a longer time interval after an acute exercise bout to determine whether bone turnover is altered by ibuprofen or other NSAIDs.

Trial registration: ClinicalTrials.gov: NCT00462722; Posted 04/19/2007

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Title: Ibuprofen taken before exercise blunts the IL-6 response in older adults but does not alter bone alkaline phosphatase or c-telopeptide
Authors: Sarah J. Wherry
Pamela Wolfe
Robert S. Schwartz
Wendy M. Kohrt
Catherine M. Jankowski
Publication date: 01-08-2021
Publisher: Springer Berlin Heidelberg
Keyword: Ibuprofen
Published in: European Journal of Applied Physiology / Issue 8/2021
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-021-04691-8

At a glance: The STEP trials

Springer Medicine

Ibuprofen taken before exercise blunts the IL-6 response in older adults but does not alter bone alkaline phosphatase or c-telopeptide

Abstract

Introduction

Purpose

Methods

Results

Conclusion

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Purpose

Methods

Results

Conclusion

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