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World Journal of Surgery

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Open Access 01-02-2018 | Original Scientific Report

Hypoxia Increases Thyroid Cancer Stem Cell-Enriched Side Population

Authors: K. Mahkamova, N. Latar, S. Aspinall, A. Meeson

Published in: World Journal of Surgery | Issue 2/2018

Abstract

Introduction

Hypoxic stress is a feature of rapidly growing thyroid tumours. Cancer progression is thought to be driven by a small population of tumour cells possessing stem cell properties. Hypoxia-inducible factors (HIFs) are important mediators of hypoxia. Both HIF-1alpha and HIF-2alpha have been reported to be expressed in thyroid cancers. There is growing evidence that the HIF pathway plays a significant role in the maintenance of thyroid cancer stem cells (CSC).

Methodology

We have isolated thyroid CSC from a papillary thyroid cancer-derived cell line (BCPAP) and an anaplastic thyroid cancer-derived cell line (SW1736) as side population (SP) cells (a putative stem cell population) and treated them with cobalt chloride (II) to induce hypoxia.

Results and discussion

We observed an increase in the SP of cells within the thyroid cancer cell lines following induction of hypoxia.

Kitahara C, Sosa J (2016) The changing incidence of thyroid cancer. Nat Rev Endocrinol 12:646–653CrossRefPubMed

Madani A, Tabah R, How J et al (2015) Rare metastases of well-differentiated thyroid cancers: a systematic review. Ann Surg Oncol 22:460–466CrossRefPubMed

Benbassat C, Hirsch D (2006) Clinicopathological characteristics and long-term outcome in patients with distant metastases from differentiated thyroid cancer. World J Surg 30:1088–1095CrossRefPubMed

Durante C, Baudin E, Leboulleux S et al (2006) Long-term outcome of 444 patients with distant metastases from papillary and follicular thyroid carcinoma: benefits and limits of radioiodine therapy. J Clin Endocrinol Metab 91:2892–2899CrossRefPubMed

Lee J (2010) Differentiated thyroid carcinoma presenting with distant metastasis at initial diagnosis clinical outcomes and prognostic factors. Ann Surg 251:114–119CrossRefPubMed

Chiacchio S, Lorenzoni A, Boni G et al (2008) Anaplastic thyroid cancer: prevalence, diagnosis and treatment. Minerva Endocrinol 33:341–357PubMed

Majmundar AJ, Wong WJ, Simon MC (2010) Hypoxia-inducible factors and the response to hypoxic stress. Mol Cell 40:294–309CrossRefPubMedPubMedCentral

Burrows N, Babur M, Resch J et al (2011) Hypoxia-inducible factor in thyroid carcinoma. J Thyroid Res 2011:762905CrossRefPubMedPubMedCentral

Burrows N, Resch J, Cowen RL et al (2010) Expression of hypoxia-inducible factor 1 alpha in thyroid carcinomas. Endocr Relat Cancer 17:61–72CrossRefPubMedPubMedCentral

10.

Moore N, Lyle S (2011) Quiescent, slow-cycling stem cell populations in cancer: a review of evidence and discussion of significance. J Oncol. https://doi.org/10.1155/2011/396076 PubMed

11.

Seidel S, Garvalov BK, Wirta V et al (2010) A hypoxic niche regulates glioblastoma stem cells through hypoxia inducible factor 2a. Brain 133:983–995CrossRefPubMed

12.

Mitsutake N, Iwao A, Nagai K et al (2007) Characterization of side population in thyroid cancer cell lines: cancer stem-like cells are enriched partly but not exclusively. Endocrinology 148:1797–1803CrossRefPubMed

13.

Lan L, Cui D, Nowka K et al (2007) Stem cells derived from goiters in adults form spheres in response to intense growth stimulation and require thyrotropin for differentiation into thyrocytes. J Clin Endocrinol Metab 92:3681–3688CrossRefPubMed

14.

Chen G, Xu S, Renko K et al (2012) Metformin inhibits growth of thyroid carcinoma cells, suppresses self-renewal of derived cancer stem cells and potentiates the effect of chemotherapeutic agents. J Clin Endocrinol Metab 97:E510–E520CrossRefPubMed

15.

Zheng X, Cui D, Xu S et al (2010) Doxorubicin fails to eradicate cancer stem cells derived from anaplastic thyroid carcinoma cells: characterisation of resistant cells. Int J Oncol 37:307–315CrossRefPubMed

16.

Xing M (2005) BRAF mutation in thyroid cancer. Endocr Relat Cancer 12:245–262CrossRefPubMed

17.

Guerra A, Di Crescenzo V, Garzi A et al (2013) Genetic mutations in the treatment of anaplastic thyroid cancer: a systematic review. BMC Surg 13:S44CrossRefPubMedPubMedCentral

18.

Salnikow K, Donald SP, Bruick RK et al (2004) Depletion of intracellular ascorbate by the carcinogenic metals nickel and cobalt results in the induction of hypoxic stress. J Biol Chem 279:40337–40344CrossRefPubMed

19.

Cho J, Kim D, Lee S et al (2005) Cobalt chloride-induced estrogen receptor α down-regulation involves hypoxia-inducible factor-1α in MCF-7 human breast cancer cells. Mol Endocrinol 19:1191–1199CrossRefPubMed

20.

Patrawala L, Schneider-Broussard R, Zhou J et al (2005) Side population is enriched in tumorigenic, stem-like cancer cells, whereas ABCG2+ and ABCG2− cancer cells are similarly tumorigenic. Can Res 65:6207–6219CrossRef

21.

Koperek O, Akin E, Asari R et al (2013) Expression of hypoxia inducible factor 1 alpha in papillary thyroid carcinoma is associated with desmoplastic stromal reaction and lymph node metastases. Virchows Arch 463:795–802CrossRefPubMed

22.

Wang N, Dong CR, Jiang R (2014) Overexpression of HIF-1alpha, metallothionein and SLUG is associated with high TNM stage, lymph node metastases in papillary thyroid carcinoma. Int J Clin Exp Patholog 7:322–330

23.

Lan L, Cui D (2013) Epithelial-mesenchymal transition triggers cancer stem cell generation in human thyroid cancer cells. Int J Oncol 43:113–120CrossRefPubMed

24.

de Jong MC, Pramana J, van der Wal JE et al (2010) CD44 expression predicts local recurrence after radiotherapy in larynx cancer. Clin Cancer Res 16:5329–5338CrossRefPubMed

Title: Hypoxia Increases Thyroid Cancer Stem Cell-Enriched Side Population
Authors: K. Mahkamova
N. Latar
S. Aspinall
A. Meeson
Publication date: 01-02-2018
Publisher: Springer International Publishing
Published in: World Journal of Surgery / Issue 2/2018
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI: https://doi.org/10.1007/s00268-017-4331-x

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Hypoxia Increases Thyroid Cancer Stem Cell-Enriched Side Population

Abstract

Introduction

Methodology

Results and discussion

At a glance: The ONWARDS insulin icodec trials

Springer Medicine

Abstract

Introduction

Methodology

Results and discussion

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