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BMC Pediatrics

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Open Access 01-12-2024 | Hypophosphatasia | Research

Nomogram for predicting early hypophosphatemia in term infants

Authors: Wan Tao, Shina Zhan, Yingjie Shen, Tianjiao Zhao, Feitian Li, Miao Gao, Tingting Yang, Jinqian Yu

Published in: BMC Pediatrics | Issue 1/2024

Abstract

Background

Physiological processes rely on phosphate, which is an essential component of adenosine triphosphate (ATP). Hypophosphatasia can affect nearly every organ system in the body. It is crucial to monitor newborns with risk factors for hypophosphatemia and provide them with the proper supplements. We aimed to evaluate the risk factors and develop a nomogram for early hypophosphatemia in term infants.

Methods

We conducted a retrospective study involving 416 term infants measured serum phosphorus within three days of birth. The study included 82 term infants with hypophosphatemia (HP group) and 334 term infants without hypophosphatemia (NHP group). We collected data on the characteristics of mothers, newborn babies, and childbirth. Furthermore, univariate and multivariate logistic regression analyses were performed to identify independent risk factors for hypophosphatemia in term infants, and a nomogram was developed and validated based on the final independent risk factors.

Results

According to our analysis, the multivariate logistic regression analysis showed that male, maternal diabetes, cesarean delivery, lower serum magnesium, and lower birth weight were independent risk factors for early hypophosphatemia in term infants. In addition, the C-index of the developed nomogram was 0.732 (95% CI = 0.668–0.796). Moreover, the calibration curve indicated good consistency between the hypophosphatemia diagnosis and the predicted probability, and a decision curve analysis (DCA) confirmed the clinical utility of the nomogram.

Conclusions

The analysis revealed that we successfully developed and validated a nomogram for predicting early hypophosphatemia in term infants.

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Title: Nomogram for predicting early hypophosphatemia in term infants
Authors: Wan Tao
Shina Zhan
Yingjie Shen
Tianjiao Zhao
Feitian Li
Miao Gao
Tingting Yang
Jinqian Yu
Publication date: 01-12-2024
Publisher: BioMed Central
Keyword: Hypophosphatasia
Published in: BMC Pediatrics / Issue 1/2024
Electronic ISSN: 1471-2431
DOI: https://doi.org/10.1186/s12887-024-04737-8

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Nomogram for predicting early hypophosphatemia in term infants

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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