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Open Access 01-12-2023 | Hyponatremia | Case Report

Presentation of severe brucellosis in 5-year-old boy - challenges and results

Authors: Yulia Dinikina, Uliana Tsoy, Andrey Dyachkov, Roman Grozov, Aleksandr Mushkin, Vyacheslav Zorin, Irina Nikitina, Elena Grineva

Published in: BMC Infectious Diseases | Issue 1/2023

Abstract

Brucellosis is highly contagious zoonotic bacterial disease caused by gram-negative genus. It has a wide spectrum of clinical manifestations and due to variety and nonspecificity of clinical signs the diagnostics can be very complicated. We present a clinical case of severe chronic brucellosis in a 5-years old boy with long-term course of disease and multiorgan involvement. A different complication of brucellosis including severe syndrome of inappropriate ADH secretion (SIADH) are discussed. Despite severe course of disease patient achieved significant clinical improvement due to multidisciplinary approach and optimal etiotropic and pathogenetic treatment.

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Ponomarenko DG, Skudareva ON, Khachaturova AA, Germanova AN, Lukashevich DE, Logvinenko OV, Rakitina EL, Kostyuchenko MV, Zinchenko DA, Semenko OV, Maletskaya OV, Kulichenko AN. Epizootiological and Epidemiological Situation on Brucellosis around the World in 2011–2020 and Forecast for the Russian Federation for 2021. Probl Particularly Danger Infections]. 2021;2:41–51. https://doi.org/10.21055/0370-1069-2021-2-41-51. Problemy osobo opasnykh infektsii [.CrossRef

Bukhari EE. Pediatric brucellosis. An update review for the new millennium. Saudi Med J. 2018;39(4):336–41. https://doi.org/10.15537/smj.2018.4.21896.CrossRefPubMedPubMedCentral

Kurmanov B, Zincke D, Su W, Hadfield TL, Aikimbayev A, Karibayev T, Berdikulov M, Orynbayev M, Nikolich MP, Blackburn JK. Assays for Identification and Differentiation of Brucella Species: A Review. Microorganisms. 2022 Aug 6;10(8):1584. https://doi.org/10.3390/microorganisms10081584. PMID: 36014002; PMCID: PMC9416531.

Alshaalan M, Alalola SA, Almuneef MA, Albanyan EA, Balkhy HH, Alshahrani DA, AlJohani S. Brucellosis in children: Prevention, diagnosis and management guidelines for general pediatricians endorsed by the Saudi Pediatric Infectious Diseases Society (SPIDS). Int J Pediatr Adolesc Med. 2014;1:40–6. https://doi.org/10.1016/j.ijpam.2014.09.004.CrossRef

Sasan MS, Nateghi M, Bonyadi B, Aelami MH. Clinical features and long-term prognosis of childhood brucellosis in northeast Iran. Iran J Pediatr. 2012;22:319–25.PubMedPubMedCentral

Fazylov VKh, Girmullina FS, Zagidullina AI, Khamidullina ZL. Diagnosis and treatment of chronic brucellosis in actual practice. Practical Med. 2014;7(83):75–9.

Kawakami N, Wakai Y, Saito K, Imaoka K. Chronic brucellosis in Japan. Intern Med. 2019;58(21):3179–83. https://doi.org/10.2169/internalmedicine.CrossRefPubMedPubMedCentral

Bala KA, Dogan M, Kaba S, Akbayram S, Aslan O, Kocaman S, Bayhan GI, Üstyol L, Demir N. The syndrome of Inappropriate Secretion of Anti-Diuretic Hormon (SIADH) and brucellosis. Med Sci Monit. 2016;22:3129–34. 10.126559/MSM.899977.CrossRefPubMedPubMedCentral

Mohamed MFH, Ahmed AOE, Habib MB, Abdalla M, Almohtasib YS, Mohamed HFH, Mohamed ZAS, Abdalla L, Saleh AO. The prevalence of the syndrome of inappropriate antidiuretic hormone secretion (SIADH) in brucellosis patients: systematic review and meta-analysis. Ann Med Surg (Lond). 2022;74:103340. https://doi.org/10.1016/j.amsu.2022.103340.CrossRefPubMed

10.

Turel O, Sanli K, Hatipoglu N, Aydogmus C, Hatipoglu H, Siraneci R. Acute meningoencephalitis due to Brucella: case report and review of neurobrucellosis in children. Turk J pediatr. 2010;52:426–9.PubMed

11.

Al Barraq AA, Makeen HA, Menachery SJ. Pediatric brucellosis: a short review. Saudi J Health Scences. 2018;7:1–6. https://doi.org/10.4103/sjhs_47_17.CrossRef

12.

Salehi M, Salehi H, Salehi MM, Salehi M. Comparison between antibiotic therapy of brucellosis with and without vitamin A. Adv Biomed Res. 2014;3:245. https://doi.org/10.4103/2277-9175.146365.CrossRefPubMedPubMedCentral

13.

Kurtaran B, Akyildiz O, Ulu AC, Inal SA, Komur S, Seydaoglu G, Arslan YK, Yaman A, Kibar F, Aksu HSZ, Tasova Y. The relationship between brucellosis and vitamin D. The journal of infection in developing contries. 2016; 10(2):176–182. https://doi.org/10.3855/jidc.5675.

14.

Guven T, Ugurlu K, Ergonul O, Celikbas AK, Gok SE, Comoglu S, Baykam N, Dokuzoguz B. Neurobrucellosis: clinical and diagnostic features. Clin Infect Dis. 2013;56(10):1407–12. https://doi.org/10.1093/cid/cit072.CrossRefPubMed

15.

El-Koumi MA, Afify M, Al-Zahrani H. A prospective study of brucellosis in children: relative frequency of pancytopenia. Iran J Pediatr. 2014;24(2):155–60.PubMed

16.

Dulger AC, Aslan M, Ceylan MR, Olmez S, Karadas S, Akdeniz H. The syndrome of Inappropriate Secretion of AntiDiuretic hormone in patients with brucellosis. J Clin Lab Anal. 2015;29(5):366–9. https://doi.org/10.1002/jcla.21780.CrossRefPubMed

17.

Zhao XY, Zhu JH, Tong LA, Xia P, Wang JL. [Clinical Characteristics of Brucellosis Complicated by Syndrome of Inappropriate Secretion of Antidiuresis]. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2019; 41(6):787–792. https://doi.org/10.3881/j.issn.1000-503X.11261. PMID: 31907128.

18.

Aysha MH, Shayib MA. Syndrome of inappropriate secretion of antidiuretic hormone in brucellosis. J Infect. 1988;17(1):29–33. https://doi.org/10.1016/s0163-4453(88)92260-8. PMID: 3204268.

19.

Ariza J, Pellicer T, Pallares R, Foz A, Gudiol F. Specific antibody profile in human brucellosis. Clin Infect Dis. 1992;14(1):131–40. https://doi.org/10.1093/clinids/14.1.131.CrossRefPubMed

20.

McLean DR, Russell N, Khan MY. Neurobrucellosis:clinical and therapeutic features.Clin Infect Dis. 1992Oct;15(4):582–90.

21.

Corbel MJ, Food, and Agriculture Organization of the United Nations., World Health Organization & World Organisation for Animal Health. (2006). Brucellosis in humansanimals. World Health Organization. https://apps.who.int/iris/handle/10665/43597.

22.

Scian R, Barrionuevo P, Fossati CA, Giambartolomei GH, Delpino MV. Brucella abortus Invasion of osteoblasts inhibits bone formation. Infect Immun. 2012;80(7):2333–45. https://doi.org/10.1128/IAI.00208-12.CrossRefPubMedPubMedCentral

23.

Aziz S, Al-Anazi AR, Al-Aska AI. A review of gastrointestinal manifestations of brucellosis. Saudi J Gastroenterol [serial online]. 2005;11:20–7.CrossRefPubMed

24.

Stermer E, Levy N, Potasman I, Jaffe M, Boss J. Brucellosis as a case of severe colitis. Am J Gastroenterol. 1991;86:917–9.PubMed

25.

Ariza J, Servitje O, Pallarés R, Fernández Viladrich P, Rufí G, Peyrí J, Gudiol F. Characteristic cutaneous lesions in patients with brucellosis. Arch Dermatol. 1989 Mar;125(3):380-3. PMID: 2923445.

26.

Esmaeilnejad-Ganji SM, Esmaeilnejad-Ganji SMR. Osteoarticular manifestations of human brucellosis: a review. World J Orthop. 2019;10(2):54–62. https://doi.org/10.5312/wjo.v10.i2.54.CrossRefPubMedPubMedCentral

27.

Raida BS, Faten F, Rim K, Boudawara T, Bahloul Z. Un exceptional cause of lymphocytic colitis: brucellosis. Hematol Med Oncol. 2017;2(4):1–2. https://doi.org/10.15761/HMO.1000134.CrossRef

28.

Logvinenko OV, Rakitina CL, Ponomarenko DG, Kostychenko MV, Sarkisian NS, Berdnikova TV. The features of blood immunological parameters in patients with various forms of brucellosis. Infekcia I immunitet (Infection and Immunity). 2013; 3(3):275–278.

29.

Araj GF, Lulu AR, Khateeb MI, Haj M. Specific ig E response in patients with brucellosis. Epidemiol Infect. 1990;105:571–7.CrossRefPubMedPubMedCentral

30.

Akhtar M, Ali A. Pathology of brucellosis: a review of 88 biopsies. Ann Saudi Med. 1989;9(3):247–53.CrossRef

31.

Zheleznikova GF, Immunoglobulin E. Biological role in infectious diseases. Med Immunol. 2002;4(4–5):515–34.

32.

Zheng R, Xie S, Niyazi S, Lu X, Sun L, Zhou Y, Zhang Y, Wang K. Meta-analysis of the changes of peripheral blood T cell subsets in patients with brucellosis. J Immunol Res. 2018; 2018: 1–10. https://doi.org/10.1155/2018/8439813.

Title: Presentation of severe brucellosis in 5-year-old boy - challenges and results
Authors: Yulia Dinikina
Uliana Tsoy
Andrey Dyachkov
Roman Grozov
Aleksandr Mushkin
Vyacheslav Zorin
Irina Nikitina
Elena Grineva
Publication date: 01-12-2023
Publisher: BioMed Central
Keywords: Hyponatremia
Syndrome of Inappropriate ADH Secretion
Lymphadenopathy
Published in: BMC Infectious Diseases / Issue 1/2023
Electronic ISSN: 1471-2334
DOI: https://doi.org/10.1186/s12879-023-08138-7

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