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Published in: Sports Medicine - Open 1/2021

Open Access 01-12-2021 | Hyponatremia | Original Research Article

Prospective Observational Study of Weight-based Assessment of Sodium Supplements on Ultramarathon Performance (WASSUP)

Authors: Grant S. Lipman, Tamara Hew-Butler, Caleb Phillips, Brian Krabak, Patrick Burns

Published in: Sports Medicine - Open | Issue 1/2021

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Abstract

Background

Sodium supplements are ubiquitous in endurance running, but their impact on performance has been subjected to much debate. The objective of the study was to assess the effect of sodium supplementation as a weight-based predictor of race performance in ultramarathon runners.

Methods

Prospective observational study during an 80 km (50 mi) stage of a 6-stage 250 km (155 mi) ultramarathon in Chile, Patagonia, Namibia, and Mongolia. Finish line hydration status as measured by weight change, point-of-care serum sodium, and questionnaire provided sodium ingestion categories at 33rd percentile and 66th percentile both for weight-adjusted rate and total sodium consumption, then analyzed for significant relationships to race performance, dysnatremia, and hydration.

Results

Two hundred sixty-six participants were enrolled, with 217 (82%) with complete sodium supplement rate data, 174 (80%) with finish line sodium, and 161 (74%) with both pre-race weights and total sodium ingestion allowing weight-based analysis. Sodium intake ranged from 131–533 mg/h/kg (2–7.2 gm), with no statistically significant impact on pace, race time, or quintile rank. These outcomes did not change when sodium intake was analyzed as a continuous variable or by sub-group analysis of the 109 (68%) normonatremic runners. When controlled for weight-adjusted sodium intake, performance was poorly correlated with hydration (r = − 0.152, 95% CI − 0.348–0.057). Dehydrated runners outperformed those overhydrated, with 11% of top 25th percentile finishers dehydrated (versus 2.8% overhydrated), with 3.6 min/km faster pace and time 4.6 h faster finishing time.

Conclusions

No association was found between sodium supplement intake and ultramarathon performance. Dehydrated runners were found to have the best performance. This reinforces the message to avoid overhydration.
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Literature
2.
go back to reference Hoffman MD, Stuempfle KJ. Hydration strategies, weight change and performance in a 161 km ultramarathon. Res Sports Med. 2014;22(3):213–25.CrossRef Hoffman MD, Stuempfle KJ. Hydration strategies, weight change and performance in a 161 km ultramarathon. Res Sports Med. 2014;22(3):213–25.CrossRef
3.
go back to reference McCubbin AJ, Cox GR, Costa RJS. Sodium Intake Beliefs, Information Sources, and Intended Practices of Endurance Athletes Before and During Exercise. Int J Sport Nutr Exerc Metab. 2019;29(4):371–81.PubMed McCubbin AJ, Cox GR, Costa RJS. Sodium Intake Beliefs, Information Sources, and Intended Practices of Endurance Athletes Before and During Exercise. Int J Sport Nutr Exerc Metab. 2019;29(4):371–81.PubMed
4.
go back to reference Schwellnus MP, Nicol J, Laubscher R, Noakes TD. Serum electrolyte concentrations and hydration status are not associated with exercise associated muscle cramping (EAMC) in distance runners. Br J Sports Med. 2004;38(4):488–92.CrossRef Schwellnus MP, Nicol J, Laubscher R, Noakes TD. Serum electrolyte concentrations and hydration status are not associated with exercise associated muscle cramping (EAMC) in distance runners. Br J Sports Med. 2004;38(4):488–92.CrossRef
5.
go back to reference Speedy DB, Thompson JM, Rodgers I, Collins M, Sharwood K, Noakes TD. Oral salt supplementation during ultradistance exercise. Clin J Sport Med. 2002;12(5):279–84.CrossRef Speedy DB, Thompson JM, Rodgers I, Collins M, Sharwood K, Noakes TD. Oral salt supplementation during ultradistance exercise. Clin J Sport Med. 2002;12(5):279–84.CrossRef
6.
go back to reference Hew-Butler TD, Sharwood K, Collins M, Speedy D, Noakes T. Sodium supplementation is not required to maintain serum sodium concentrations during an Ironman triathlon. Br J Sports Med. 2006;40(3):255–9.CrossRef Hew-Butler TD, Sharwood K, Collins M, Speedy D, Noakes T. Sodium supplementation is not required to maintain serum sodium concentrations during an Ironman triathlon. Br J Sports Med. 2006;40(3):255–9.CrossRef
8.
go back to reference Hew-Butler T, Rosner MH, Fowkes-Godek S, Dugas JP, Hoffman MD, Lewis DP, et al. Statement of the Third International Exercise-Associated Hyponatremia Consensus Development Conference, Carlsbad, California, 2015. Clin J Sports Med. 2015;25(4):303–20.CrossRef Hew-Butler T, Rosner MH, Fowkes-Godek S, Dugas JP, Hoffman MD, Lewis DP, et al. Statement of the Third International Exercise-Associated Hyponatremia Consensus Development Conference, Carlsbad, California, 2015. Clin J Sports Med. 2015;25(4):303–20.CrossRef
9.
go back to reference Meyer LG, Horrigan DJ Jr, Lotz WG. Effects of three hydration beverages on exercise performance during 60 hours of heat exposure. Aviat Space Environ Med. 1995;66(11):1052–7.PubMed Meyer LG, Horrigan DJ Jr, Lotz WG. Effects of three hydration beverages on exercise performance during 60 hours of heat exposure. Aviat Space Environ Med. 1995;66(11):1052–7.PubMed
10.
go back to reference Sterns RH. Disorders of plasma sodium--causes, consequences, and correction. N Engl J Med. 2015;372(1):55–65.CrossRef Sterns RH. Disorders of plasma sodium--causes, consequences, and correction. N Engl J Med. 2015;372(1):55–65.CrossRef
11.
go back to reference Baker LB, De Chavez PJD, Ungaro CT, Sopeña BC, Nuccio RP, Reimel AJ, et al. Exercise intensity effects on total sweat electrolyte losses and regional vs. whole-body sweat [Na(+)], [Cl(-)], and [K(+)]. Eur J Appl Physiol. 2019;119(2):361–75.CrossRef Baker LB, De Chavez PJD, Ungaro CT, Sopeña BC, Nuccio RP, Reimel AJ, et al. Exercise intensity effects on total sweat electrolyte losses and regional vs. whole-body sweat [Na(+)], [Cl(-)], and [K(+)]. Eur J Appl Physiol. 2019;119(2):361–75.CrossRef
12.
go back to reference Robinson S, Nicholas JR, Smith JH, Daly WJ, Pearcy M. Time relation of renal and sweat gland adjustments to salt deficiency in men. J Appl Physiol. 1955;8(2):159–65.CrossRef Robinson S, Nicholas JR, Smith JH, Daly WJ, Pearcy M. Time relation of renal and sweat gland adjustments to salt deficiency in men. J Appl Physiol. 1955;8(2):159–65.CrossRef
13.
go back to reference Luetkemeier MJ, Coles MG, Askew EW. Dietary sodium and plasma volume levels with exercise. Sports Med. 1997;23(5):279–86.CrossRef Luetkemeier MJ, Coles MG, Askew EW. Dietary sodium and plasma volume levels with exercise. Sports Med. 1997;23(5):279–86.CrossRef
14.
go back to reference Titze J. A different view on sodium balance. Curr Opin Nephrol Hypertens. 2015;24(1):14–20.CrossRef Titze J. A different view on sodium balance. Curr Opin Nephrol Hypertens. 2015;24(1):14–20.CrossRef
15.
go back to reference Takamata A, Mack GW, Gillen CM, Nadel ER. Sodium appetite, thirst, and body fluid regulation in humans during rehydration without sodium replacement. Am J Physiol. 1994;266(5 Pt 2):R1493–502.PubMed Takamata A, Mack GW, Gillen CM, Nadel ER. Sodium appetite, thirst, and body fluid regulation in humans during rehydration without sodium replacement. Am J Physiol. 1994;266(5 Pt 2):R1493–502.PubMed
16.
go back to reference Thomas DT, Erdman KA, Burke LM. American College of Sports Medicine Joint Position Statement. Nutrition and Athletic Performance. Med Sci Sports Exerc. 2016;48(3):543–68.CrossRef Thomas DT, Erdman KA, Burke LM. American College of Sports Medicine Joint Position Statement. Nutrition and Athletic Performance. Med Sci Sports Exerc. 2016;48(3):543–68.CrossRef
17.
go back to reference Shirreffs SM, Sawka MN. Fluid and electrolyte needs for training, competition, and recovery. J Sports Sci. 2011;29(Suppl 1):S39–46.CrossRef Shirreffs SM, Sawka MN. Fluid and electrolyte needs for training, competition, and recovery. J Sports Sci. 2011;29(Suppl 1):S39–46.CrossRef
20.
go back to reference Adams JD, Sekiguchi Y, Suh HG, Seal AD, Sprong CA, Kirkland TW, et al. Dehydration Impairs Cycling Performance, Independently of Thirst: A Blinded Study. Med Sci Sports Exerc. 2018;50(8):1697–703.CrossRef Adams JD, Sekiguchi Y, Suh HG, Seal AD, Sprong CA, Kirkland TW, et al. Dehydration Impairs Cycling Performance, Independently of Thirst: A Blinded Study. Med Sci Sports Exerc. 2018;50(8):1697–703.CrossRef
21.
go back to reference Goulet ED. Effect of exercise-induced dehydration on time-trial exercise performance: a meta-analysis. Br J Sports Med. 2011;45(14):1149–56.CrossRef Goulet ED. Effect of exercise-induced dehydration on time-trial exercise performance: a meta-analysis. Br J Sports Med. 2011;45(14):1149–56.CrossRef
22.
go back to reference Currell K, Jeukendrup AE. Superior endurance performance with ingestion of multiple transportable carbohydrates. Med Sci Sports Exerc. 2008;40(2):275–81.CrossRef Currell K, Jeukendrup AE. Superior endurance performance with ingestion of multiple transportable carbohydrates. Med Sci Sports Exerc. 2008;40(2):275–81.CrossRef
23.
go back to reference Stuempfle KJ, Hoffman MD, Weschler LB, Rogers IR, Hew-Butler T. Race diet of finishers and non-finishers in a 100 mile (161 km) mountain footrace. J Am Coll Nutr. 2011;30(6):529–35.CrossRef Stuempfle KJ, Hoffman MD, Weschler LB, Rogers IR, Hew-Butler T. Race diet of finishers and non-finishers in a 100 mile (161 km) mountain footrace. J Am Coll Nutr. 2011;30(6):529–35.CrossRef
24.
go back to reference Del Coso J, Gonzalez-Millan C, Salinero JJ, Abian-Vicen J, Areces F, Lledo M, et al. Effects of oral salt supplementation on physical performance during a half-ironman: A randomized controlled trial. Scand J Med Sci Sports. 2016;26(2):156–64.CrossRef Del Coso J, Gonzalez-Millan C, Salinero JJ, Abian-Vicen J, Areces F, Lledo M, et al. Effects of oral salt supplementation on physical performance during a half-ironman: A randomized controlled trial. Scand J Med Sci Sports. 2016;26(2):156–64.CrossRef
25.
go back to reference Twerenbold R, Knechtle B, Kakebeeke TH, Eser P, Müller G, von Arx P, et al. Effects of different sodium concentrations in replacement fluids during prolonged exercise in women. Br J Sports Med. 2003;37(4):300–3.CrossRef Twerenbold R, Knechtle B, Kakebeeke TH, Eser P, Müller G, von Arx P, et al. Effects of different sodium concentrations in replacement fluids during prolonged exercise in women. Br J Sports Med. 2003;37(4):300–3.CrossRef
26.
go back to reference Hoffman MD, Stuempfle KJ. Does oral buffered sodium supplementation reduce nausea and vomiting during an ultramarathon? Res Sports Med. 2016;24(1):94–103.CrossRef Hoffman MD, Stuempfle KJ. Does oral buffered sodium supplementation reduce nausea and vomiting during an ultramarathon? Res Sports Med. 2016;24(1):94–103.CrossRef
27.
go back to reference Hoffman MD, Hew-Butler T, Stuempfle KJ. Exercise-associated hyponatremia and hydration status in 161-km ultramarathoners. Med Sci Sports Exerc. 2013;45(4):784–91.CrossRef Hoffman MD, Hew-Butler T, Stuempfle KJ. Exercise-associated hyponatremia and hydration status in 161-km ultramarathoners. Med Sci Sports Exerc. 2013;45(4):784–91.CrossRef
28.
go back to reference Krabak BJ, Lipman GS, Waite BL, Rundell SD. Exercise-associated hyponatremia, hypernatremia, and hydration status in multistage ultramarathons. Wilderness Environ Med. 2017;28(4):291–8.CrossRef Krabak BJ, Lipman GS, Waite BL, Rundell SD. Exercise-associated hyponatremia, hypernatremia, and hydration status in multistage ultramarathons. Wilderness Environ Med. 2017;28(4):291–8.CrossRef
29.
go back to reference Lipman GS, Shea K, Christensen M, Phillips C, Burns P, Higbee R, et al. Ibuprofen versus placebo effect on acute kidney injury in ultramarathons: a randomised controlled trial. Emerg Med J. 2017;34(10):637–42.CrossRef Lipman GS, Shea K, Christensen M, Phillips C, Burns P, Higbee R, et al. Ibuprofen versus placebo effect on acute kidney injury in ultramarathons: a randomised controlled trial. Emerg Med J. 2017;34(10):637–42.CrossRef
30.
go back to reference Noakes TD, Sharwood K, Speedy D, Hew T, Reid S, Dugas J, et al. Three independent biological mechanisms cause exercise-associated hyponatremia: evidence from 2,135 weighed competitive athletic performances. Proc Natl Acad Sci USA. 2005;102(51):18550-5. Noakes TD, Sharwood K, Speedy D, Hew T, Reid S, Dugas J, et al. Three independent biological mechanisms cause exercise-associated hyponatremia: evidence from 2,135 weighed competitive athletic performances. Proc Natl Acad Sci USA. 2005;102(51):18550-5.
31.
go back to reference Barr SI, Costill DL, Fink WJ. Fluid replacement during prolonged exercise: effects of water, saline, or no fluid. Med Sci Sports Exerc. 1991;23(7):811–7.PubMed Barr SI, Costill DL, Fink WJ. Fluid replacement during prolonged exercise: effects of water, saline, or no fluid. Med Sci Sports Exerc. 1991;23(7):811–7.PubMed
32.
go back to reference Ebert TR, Martin DT, Bullock N, Mujika I, Quod MJ, Farthing LA, et al. Influence of hydration status on thermoregulation and cycling hill climbing. Med Sci Sports Exerc. 2007;39(2):323–9.CrossRef Ebert TR, Martin DT, Bullock N, Mujika I, Quod MJ, Farthing LA, et al. Influence of hydration status on thermoregulation and cycling hill climbing. Med Sci Sports Exerc. 2007;39(2):323–9.CrossRef
33.
go back to reference Sharwood KA, Collins M, Goedecke JH, Wilson G, Noakes TD. Weight changes, medical complications, and performance during an Ironman triathlon. Br J Sports Med. 2004;38(6):718–24.CrossRef Sharwood KA, Collins M, Goedecke JH, Wilson G, Noakes TD. Weight changes, medical complications, and performance during an Ironman triathlon. Br J Sports Med. 2004;38(6):718–24.CrossRef
34.
go back to reference Wichardt E, Mattsson CM, Ekblom B, Henriksson-Larsén K. Rhabdomyolysis/myoglobinemia and NSAID during 48 h ultra-endurance exercise (adventure racing). Eur J Appl Physiol. 2011;111(7):1541–4.CrossRef Wichardt E, Mattsson CM, Ekblom B, Henriksson-Larsén K. Rhabdomyolysis/myoglobinemia and NSAID during 48 h ultra-endurance exercise (adventure racing). Eur J Appl Physiol. 2011;111(7):1541–4.CrossRef
35.
go back to reference Wharam PC, Speedy DB, Noakes TD, Thompson JM, Reid SA, Holtzhausen LM. NSAID use increases the risk of developing hyponatremia during an Ironman triathlon. Med Sci Sports Exerc. 2006;38(4):618–22.CrossRef Wharam PC, Speedy DB, Noakes TD, Thompson JM, Reid SA, Holtzhausen LM. NSAID use increases the risk of developing hyponatremia during an Ironman triathlon. Med Sci Sports Exerc. 2006;38(4):618–22.CrossRef
36.
go back to reference Knechtle B, Knechtle P, Wirth A, Rust CA, Roseman T. A faster running speed is associated with a greater body weight loss in 100-km ultra-marathoners. J Sports Sci. 2012;30:1131–40.CrossRef Knechtle B, Knechtle P, Wirth A, Rust CA, Roseman T. A faster running speed is associated with a greater body weight loss in 100-km ultra-marathoners. J Sports Sci. 2012;30:1131–40.CrossRef
37.
go back to reference Speedy D, Noakes T, Rogers IR. Hyponatremia in ultradistance triathletes. Med Sci Sports Exerc. 1999;31:809–15.CrossRef Speedy D, Noakes T, Rogers IR. Hyponatremia in ultradistance triathletes. Med Sci Sports Exerc. 1999;31:809–15.CrossRef
38.
go back to reference Cosgrove SD, Black KE. Sodium supplementation has no effect on endurance performance during a cycling time-trial in cool conditions: a randomised cross-over trial. J Int Soc Sports Nutr. 2013;10:30.CrossRef Cosgrove SD, Black KE. Sodium supplementation has no effect on endurance performance during a cycling time-trial in cool conditions: a randomised cross-over trial. J Int Soc Sports Nutr. 2013;10:30.CrossRef
39.
go back to reference Royal College of Paediatrics and Child Health. The differential diagnosis of hypernatremia in children, with particular reference to salt poisoning - an evidenced-based guideline. 2009;1-106:9. Royal College of Paediatrics and Child Health. The differential diagnosis of hypernatremia in children, with particular reference to salt poisoning - an evidenced-based guideline. 2009;1-106:9.
40.
go back to reference Hoffman MD, Stuempfle KJ. Sodium supplementation and exercise-associated hyponatremia during prolonged exercise. Med Sci Sports Exerc. 2015;47(9):1781–7.CrossRef Hoffman MD, Stuempfle KJ. Sodium supplementation and exercise-associated hyponatremia during prolonged exercise. Med Sci Sports Exerc. 2015;47(9):1781–7.CrossRef
Metadata
Title
Prospective Observational Study of Weight-based Assessment of Sodium Supplements on Ultramarathon Performance (WASSUP)
Authors
Grant S. Lipman
Tamara Hew-Butler
Caleb Phillips
Brian Krabak
Patrick Burns
Publication date
01-12-2021
Publisher
Springer International Publishing
Keyword
Hyponatremia
Published in
Sports Medicine - Open / Issue 1/2021
Print ISSN: 2199-1170
Electronic ISSN: 2198-9761
DOI
https://doi.org/10.1186/s40798-021-00302-0

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