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Annals of General Psychiatry
Published in: Annals of General Psychiatry 1/2016

Open Access 01-12-2016 | Primary research

Hyperthymic affective temperament and hypertension are independent determinants of serum brain-derived neurotrophic factor level

Authors: János Nemcsik, Andrea László, Lilla Lénárt, Dániel Eörsi, Péter Torzsa, Beáta Kőrösi, Orsolya Cseprekál, András Tislér, Ádám Tabák, Xenia Gonda, Zoltán Rihmer, Judit Hodrea, Zsófia Nemcsik-Bencze, Andrea Fekete

Published in: Annals of General Psychiatry | Issue 1/2016

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Abstract

Background

Brain-derived neurotrophic factor (BDNF) has neuroprotective, proangiogenic and myogenic effects and, therefore, possibly acts as a psychosomatic mediator. Here, we measured serum BDNF (seBDNF) level in hypertensive patients (HT) and healthy controls (CONT) and its relation to affective temperaments, depression and anxiety scales, and arterial stiffness parameters.

Methods

In this cross-sectional study, affective temperaments, anxiety, and depression were studied with questionnaires (TEMPS-A, HAM-A, and BDI, respectively). SeBDNF level and routine laboratory parameters were measured as well. Arterial stiffness was evaluated with a tonometric method.

Results

Allover, 151 HT, and 32 CONT subjects were involved in the study. SeBDNF level was significantly higher in HT compared to CONT (24880 ± 8279 vs 21202.6 ± 6045.5 pg/mL, p < 0.05). In the final model of regression analysis, hyperthymic temperament score (Beta = 405.8, p = 0.004) and the presence of hypertension (Beta = 6121.2, p = 0.001) were independent determinants of seBDNF. In interaction analysis, it was found that in HT, a unit increase in hyperthymic score was associated with a 533.3 (95 %CI 241.3–825.3) pg/mL higher seBDNF. This interaction was missing in CONT.

Conclusions

Our results suggest a complex psychosomatic involvement of BDNF in the pathophysiology of hypertension, where hyperthymic affective temperament may have a protective role. BDNF is not likely to have an effect on large arteries.
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Metadata
Title
Hyperthymic affective temperament and hypertension are independent determinants of serum brain-derived neurotrophic factor level
Authors
János Nemcsik
Andrea László
Lilla Lénárt
Dániel Eörsi
Péter Torzsa
Beáta Kőrösi
Orsolya Cseprekál
András Tislér
Ádám Tabák
Xenia Gonda
Zoltán Rihmer
Judit Hodrea
Zsófia Nemcsik-Bencze
Andrea Fekete
Publication date
01-12-2016
Publisher
BioMed Central
Published in
Annals of General Psychiatry / Issue 1/2016
Electronic ISSN: 1744-859X
DOI
https://doi.org/10.1186/s12991-016-0104-4

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